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Distinguished Speaker Series | Paul Shin-Hyun Park, PhD

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Location
https://ucihealth.zoom.us/j/94483669170?pwd=WUd1clg2aUM1bnpPVHd3MlkwTUN1Zz09
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The Center for Translational Vision Research Distinguished Speaker Series, also known as "Friday Seminars" showcases innovative research across the world. The seminar series has now been expanded to include lectures by experts on topics ranging from Ophthalmology, Genetics, Biochemistry, Neurobiology, Imaging, Computational Sciences to Novel Ophthalmic Treatments.

All talks are hybrid. You can join us in person at

The Susan & Henry Samueli College of Health Sciences 

Sue Gross Auditorium.

You can also join us by zoom. Zoom link and information are on your right and in the calendar links above.

May 16, 2025 | Paul Shin-Hyun Park, PhD

Rhodopsin dysfunction in retinal disease

 

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Paul Shin-Hyun Park, PhD
Paul Shin-Hyun Park, PhD
  • Associate Professor, Department of Ophthalmology & Visual Sciences, Case Western Reserve University, Cleveland, OH

Dr. Park’s research focuses on the biology of photoreceptor cells and structure-function studies of rhodopsin and other G protein-coupled receptors (GPCRs) using cutting-edge biochemical, biophysical and genetic technologies. One of the major focuses of the laboratory is on answering long-standing fundamental questions about the structure and function of rhodopsin. Rhodopsin is the dim light receptor in rod photoreceptor cells of the retina that initiates vision upon photon capture. Mutations in the rhodopsin gene account for about 15% of all retinal degenerative disease. Mutations in rhodopsin can lead to retinitis pigmentosa and congenital stationary night blindness. Retinitis pigmentosa is the most common inherited retinal degenerative disease and affects about 1.5 million people worldwide. More than 100 point mutations have been discovered in the rhodopsin gene that is associated with night blindness or vision loss. The mechanistic basis for how rhodopsin causes these diseased states is currently unclear. Research in the laboratory will help us better understand the mechanistic basis of mutations in rhodopsin that cause inherited vision disorders and thereby provide critical insights for the discovery and implementation of targeted therapeutic strategies to combat these types of disorders.