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Welcome Message

Our Center for Translational Vision Research at the Gavin Herbert Eye Institute serves as an international leader in advancing research and bolstering the support of investigators pursuing basic and translational sciences relevant to vision. We are bringing together exceptional scientific expertise from within the University, the School of Medicine and other schools, and complementary research programs to advance collaborations that focus on fundamental discoveries in vision research with translational potential. We aim to integrate basic and clinical research, including genetics and pharmacology, in order to develop innovative and accessible therapies for millions robbed of their sight or progressing toward blindness.

Dr. Krzysztof Palczewski


Rapid RGR-dependent visual pigment recycling is mediated by the RPE and specialized Müller glia

.            Tworak A, Kolesnikov AV, Hong JD, Choi EH, Luu JC, Palczewska G, Dong Z, Lewandowski D, Brooks MJ, Campello L, Swaroop A, Kiser PD, Kefalov VJ, Palczewski K. Cell Rep. 2023 Aug 15;42(8):112982. doi: 10.1016/j.celrep.2023.112982.

Investigating the role of rhodopsin F45L mutation in mouse rod photoreceptor signaling and survival.

D. Poria, A. V. Kolesnikov, T. J. Lee, D. Salom, K. Palczewski, V. J. Kefalov. eNeuro. 2023

Stress induced aging in mouse eye.

Xu Q, Rydz C, Nguyen Huu VA, Rocha L, Palomino La Torre C, Lee I, Cho W, Jabari M, Donello J, Lyon DC, Brooke R, Horvath S, Weinreb RN, Ju WK, Foik A, Skowronska-Krawczyk D*; (2022). Aging Cell , PMID: 36397653 DOI: 10.1111/acel.13737

Distinct mouse models of Stargardt disease display differences in pharmacological targeting of ceramides and inflammatory responses.

Engfer ZJ, Lewandowski D, Dong Z, Palczewska G, Zhang J, Kordecka K, Płaczkiewicz J, Panas D, Foik AT, Tabaka M, Palczewski K. Proc Natl Acad Sci U S A. 2023 Dec 12;120(50):e2314698120. doi: 10.1073/pnas.2314698120.

A short story on how chromophore is hydrolyzed from rhodopsin for recycling.

   Hong, J. D. and K. Palczewski. Bioessays. 2023 Jul 16:e2300068.

Structural basis for the allosteric modulation of rhodopsin by nanobody binding to its extracellular domain.

  Wu A, Salom D, Hong JD, Tworak A, Watanabe K, Pardon E, Steyaert J, Kandori H, Katayama K, Kiser PD, Palczewski K. Nat Commun. 2023 Aug 25;14(1):5209. doi: 10.1038/s41467-023-40911-9.

Transient in vivo delivery of prime editor protein and pegRNA with engineered virus-like particles.

   An, M., A. Raguram, S. W. Du, S. Banskota, J. R. Davis, G. A. Newby, K. Palczewski, D. R. Liu. T. (2023) Nature Biotechnology (in press)