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BME 295/195: Modern Topics in Gene Editing and Gene Therapy

BME 295/195: Modern Topics in Gene Editing and Gene Therapy –The Department of Biomedical Engineering in collaboration with the CTVR, is excited to offer a exciting course this fall, 2023. This 10-week, 4-unit course is geared towards PhD students and advanced Undergraduates and it will give students 3 hours of contact with the instructor during class each week. Students will also have 1 hour of group discussion without the instructor in preparation for class. In addition to these commitments, students will be responsible for preparing for class by doing the reading and assignments before each class. The class will cover topics such as history of programmable nucleases, with an emphasis on CRISPR, editing and manipulating genomes using programmable nucleases and CRISPR technologies, and gene therapy applications, focusing on precision gene editing to correct disease mutations. You can register Summer 2023 for the Fall 2023 semester. Weekly course outline;

Week 1: Restriction enzymes and the challenges of manipulating DNA in vivo

Week 2: Programmable restriction enzymes: Zinc fingers

Week 3: Programmable restriction enzymes: TALENs

Week 4: CRISPR: discovery and mechanisms

Week 5: CRISPR-based manipulation of mammalian genomes

Week 6: Base editing

Week 7: Prime editing

Week 8: Case studies in gene therapy

Week 9: Case studies in gene therapy

Week 10: Ethical frameworks for gene editing and gene therapy