Publications Home Research Publications The Power of Knowledge The investigators in CTVR conduct high-power, well-funded, basic and translational research that results in publications in the most elite scientific journals. Andrew Browne, MD, PhD 2009-2022 Browne AW, Deyneka E, Ceccarelli F, To JK, Chen S, Tang J, Vu AN, Baldi PF. Deep Learning to enable color vision in the Dark. PLoS ONE. 2022 April. Xue Y, Browne AW, Tang WC, Delgado J, McLelland BT, Nistor G, Chen JT, Lee N, Keirstead HS, Seiler MJ. Retinal Organoids Long-term Functional Characterization Using Two-Photon Fluorescence Lifetime and Hyperspectral Microscopy. Frontiers in Neuroscience. 2021 December. doi: 10.3389/fncel.2021.796903. McAleer S, Fast A, Xue Y, Seiler MJ, Tang WC, Balu M, Baldi P, Browne AW. Deep Learning-Assisted Multiphoton Microscopy to Reduce Light Exposure and Expedite Imaging in Tissues With High and Low Light Sensitivity. Transl Vis Sci Technol. 2021 Oct 4;10(12):30. doi: 10.1167/tvst.10.12.30. PubMed PMID: 34668935; PubMed Central PMCID: PMC8543395. Xue Y, Seiler MJ, Tang WC, Wang JY, Delgado J, McLelland BT, Nistor G, Keirstead HS, Browne AW. Retinal organoids on-a-chip: a micro-millifluidic bioreactor for long-term organoid maintenance. Lab Chip. 2021 Sep 7;21(17):3361-3377. doi: 10.1039/d1lc00011j. Epub 2021 Jul 8. PubMed PMID: 34236056; PubMed Central PMCID: PMC8387452. Cherfan DG, Browne AW, Deasy R, Lapinski J, Srivastava SK. BEARING DOWN ON TREPONEMES: AN ATYPICAL PRESENTATION OF SYPHILITIC UVEITIS. Retin Cases Brief Rep. 2021 Jul 1;15(4):403-406. doi: 10.1097/ICB.0000000000000831. PubMed PMID: 30300313. Wei A, Mehta UV, Palczewska G, Palma AM, Hussey VM, Hoffmann LE, Diep A, Nguyen K, Le B, Chang SY, Browne AW. Two-Photon Microperimetry: A Media Opacity-Independent Retinal Function Assay. Transl Vis Sci Technol. 2021 Feb 5;10(2):11. doi: 10.1167/tvst.10.2.11. PubMed PMID: 34003895; PubMed Central PMCID: PMC7881275. Mehta U, Diep A, Nguyen K, Le B, Yuh C, Frambach C, Doan J, Wei A, Palma AM, Farid M, Garg S, Kedhar S, Wade M, Marshall KA, Jameson KA, Cristina Kenney M, Browne AW. Quantifying Color Vision Changes Associated With Cataracts Using Cone Contrast Thresholds. Transl Vis Sci Technol. 2020 Nov;9(12):11. doi: 10.1167/tvst.9.12.11. eCollection 2020 Nov. PubMed PMID: 33200052; PubMed Central PMCID: PMC7645251. Bhatter P, Cao L, Crochetiere A, Raefsky SM, Cuevas LR, Enendu K, Frisch EH, Shumway C, Gore C, Browne AW. Using a Macro Lens for Anterior Segment Imaging in Rural Panama. Telemed J E Health. 2020 Nov;26(11):1414-1418. doi: 10.1089/tmj.2019.0152. Epub 2020 Feb 7. PubMed PMID: 32031913; PubMed Central PMCID: PMC7698642. Bui AD, Diep AL, Lin Q, Minckler DS, Browne AW, Wang AL. Multimodal Imaging in Ocular Siderosis. Journal of VitreoRetinal Diseases. 2020 October. doi: 10.1177/2474126420962020. Browne AW, Ansari W, Hu M, Baynes K, Lowder CY, Ehlers JP, Srivastava SK. Quantitative Analysis of Ellipsoid Zone in Acute Posterior Multifocal Placoid Pigment Epitheliopathy. J Vitreoretin Dis. 2020 Jun 1;4(3):192-201. doi: 10.1177/2474126420901897. Epub 2020 Feb 11. PubMed PMID: 34084990; PubMed Central PMCID: PMC8171299. White KM, Frambach C, Doan J, Mehta UV, Livnat I, Yuh C, Palma AM, Jameson KA, Kenney MC, Browne AW. Quantitative cone contrast threshold testing in patients with differing pathophysiological mechanisms causing retinal diseases. medRxiv. 2020. Feiler DL, Browne AW, Rachitskaya AV, Taban M, Sonnie C, Hayden-Loreck BC, Sharma S, Sears JE. Indirect Cyclopexy for Repair of Cyclodialysis Clefts. Retina. 2019 Oct;39 Suppl 1:S177-S181. doi: 10.1097/IAE.0000000000002091. PubMed PMID: 29543634. Cao JL, Browne AW, Clifford T, Sharma S, Patel V. Intravitreal Silicone Oil Migration Into the Lateral Cerebral Ventricles. Journal of Vitreoretinal Disease. 2019 September; 3(6):466-473. doi: 10.1177/2474126419875298. Ramos MS, Echegaray JJ, Kuhn-Asif S, Wilkinson A, Yuan A, Singh AD, Browne AW. Animal models of radiation retinopathy - From teletherapy to brachytherapy. Exp Eye Res. 2019 Apr;181:240-251. doi: 10.1016/j.exer.2019.01.019. Epub 2019 Feb 1. Review. PubMed PMID: 30716328. Li Y, Zhu J, Chen JJ, Yu J, Browne AW, Zhou Q, Chen Z. Simultaneously imaging and quantifying in vivo mechanical properties of crystalline lens and cornea using optical coherence elastography with acoustic radiation force excitation. APL Photonics 4, 106104 (2019). 2019; 4. doi: https://doi.org/10.1063/1.5118258. Browne AW, Conti FF, Kaiser PK, Singh RP. Surgical Repair of Traumatic Macular Holes With Extreme Macular Pathology Using an Internal Limiting Membrane Flap Technique. Ophthalmic Surg Lasers Imaging Retina. 2018 Oct 1;49(10):e143-e146. doi: 10.3928/23258160-20181002-17. PubMed PMID: 30395675. Browne AW, Ehlers JP, Sharma S, Srivastava SK. Intraoperative Optical Coherence Tomography-Assisted Chorioretinal Biopsy in the DISCOVER Study. Retina. 2017 Nov;37(11):2183-2187. doi: 10.1097/IAE.0000000000001522. PubMed PMID: 28426625; PubMed Central PMCID: PMC5648642. Browne AW, Arnesano C, Harutyunyan N, Khuu T, Martinez JC, Pollack HA, Koos DS, Lee TC, Fraser SE, Moats RA, Aparicio JG, Cobrinik D. Structural and Functional Characterization of Human Stem-Cell-Derived Retinal Organoids by Live Imaging. Invest Ophthalmol Vis Sci. 2017 Jul 1;58(9):3311-3318. doi: 10.1167/iovs.16-20796. Review. PubMed PMID: 28672397; PubMed Central PMCID: PMC5495152. Ansari WH, Browne AW, Singh RP. Juvenile X-linked retinoschisis responsive to intravitreal corticosteroids. Am J Ophthalmol Case Rep. 2017 Apr;5:48-51. doi: 10.1016/j.ajoc.2016.12.002. eCollection 2017 Apr. PubMed PMID: 29503947; PubMed Central PMCID: PMC5758014. Valenzuela F, Browne A, Srur M, Nieme C, Zanolli M, López-Solís R, Traipe L. Combined Phacoemulsification and Ahmed Glaucoma Drainage Implant Surgery for Patients With Refractory Glaucoma and Cataract. J Glaucoma. 2016 Feb;25(2):162-6. doi: 10.1097/IJG.0000000000000141. PubMed PMID: 25264992. Browne AW, Dandapani SV, Jennelle R, Stevanovic M, Lee TC, Murphree AL, Kampp TD, Astrahan MA, Kim JW, Berry JL. Outcomes of medium choroidal melanomas treated with ruthenium brachytherapy guided by three-dimensional pretreatment modeling. Brachytherapy. 2015 Sep-Oct;14(5):718-25. doi: 10.1016/j.brachy.2015.04.010. Epub 2015 Jun 12. PubMed PMID: 26073224. Browne AW, Osher RH. Optimizing precision in toric lens selection by combining keratometry techniques. J Refract Surg. 2014 Jan;30(1):67-72. doi: 10.3928/1081597x-20131217-07. PubMed PMID: 24864329. Papu JT, Rust MJ, Browne AW. A portable centrifuge for point-of-care measurement of hematocrit in low-resource settings. Point of Care. 2014; 13(2):48-53. doi: 10.1097/POC.0000000000000012. Browne AW, Ahn CH. An in-line microfluidic blood sampling interface between patients and saline infusion systems. Biomed Microdevices. 2011 Aug;13(4):661-9. doi: 10.1007/s10544-011-9536-4. PubMed PMID: 21465091. Browne AW, Ramasamy L, Cripe TP, Ahn CH. A lab-on-a-chip for rapid blood separation and quantification of hematocrit and serum analytes. Lab Chip. 2011 Jul 21;11(14):2440-6. doi: 10.1039/c1lc20144a. Epub 2011 Jun 8. PubMed PMID: 21655589. Browne AW, Leddon JL, Currier MA, Williams JP, Frischer JS, Collins MH, Ahn CH, Cripe TP. Cancer screening by systemic administration of a gene delivery vector encoding tumor-selective secretable biomarker expression. PLoS One. 2011 May 11;6(5):e19530. doi: 10.1371/journal.pone.0019530. PubMed PMID: 21589655; PubMed Central PMCID: PMC3092745. Shim JS, Browne AW, Ahn CH. An on-chip whole blood/plasma separator with bead-packed microchannel on COC polymer. Biomed Microdevices. 2010 Oct;12(5):949-57. doi: 10.1007/s10544-010-9449-7. PubMed PMID: 20563751. Browne AW, Rust MJ, Jung W, Lee SH, Ahn CH. A rapid prototyping method for polymer microfluidics with fixed aspect ratio and 3D tapered channels. Lab Chip. 2009 Oct 21;9(20):2941-6. doi: 10.1039/b903755a. Epub 2009 Jul 14. PubMed PMID: 19789747. Browne AW, Hitchcock KE, Ahn CH. A PDMS pinch-valve module embedded in rigid polymer lab chips for on-chip flow regulation. Journal of micromechanics and microengineering : structures, devices, and systems. 2009; 19(11). doi: 10.1088/0960-1317/19/11/115012. Lilangi, Ediriwickrema, MD 2008-2022 Nair AA, Ediriwickrema LS, Dolman PJ, Law G, Harrison AR, Mokhtarzadeh A, Stewart K, Men C, Lucarelli MJ, van Landingham S, Wingelaar M, Verma R, Chen A,Selva D, Garrity J, Eckel L, Kazim M, Godfrey K, Baxter SL, Korn BS, Kikkawa DO.Predictive Modeling of New-Onset Postoperative Diplopia Following Orbital Decompression for Thyroid Eye Disease. Ophthalmic Plast Reconstr Surg. 2022 May 13. doi: 10.1097/IOP.0000000000002196. Epub ahead of print. PMID: 35551414. Himstead AS, Gustafson KM, Hasso AN, Ediriwickrema LS. Internal Carotid Artery Pseudoaneurysm Causing an Abducens Nerve Palsy: A Case Report. J Neuroophthalmol. 2021 Aug 18. doi: 10.1097/WNO.0000000000001387. Epub ahead of print. PMID: 35503976. Pai A, Carter S, Ediriwickrema LS. Bilateral Disc Edema Masquerade. JAMA Ophthalmol. 2021 Oct 1;139(10):1137-1138. doi: 10.1001/jamaophthalmol.2021.0096. PMID: 34351380. Chen AJ, Ediriwickrema LS, Verma R, Vavinskaya V, Shaftel S, Deconde AS, Korn BS, Kikkawa DO, Liu CY. A case of mistaken identity: Saksenaea vasiformis of the orbit. Orbit. 2021 Dec;40(6):521-524. doi: 10.1080/01676830.2020.1814354. Epub 2020 Aug 30. PMID: 32862746. Long CP, Lu T, Ediriwickrema LS, Lin JH, Korn BS, Kikkawa DO, Liu CY. Colorectal carcinoma presenting in the orbit: mass effect from an uncommon cause. Orbit. 2021 Aug;40(4):338-341. doi: 10.1080/01676830.2020.1787466. Epub 2020 Jul 9. PMID: 32643502. Men CJ, Ko AC, Ediriwickrema LS, Liu CY, Kikkawa DO, Korn BS. Canalicular laceration repair using a self-retaining, bicanalicular, hydrophilic nasolacrimal stent. Orbit. 2021 Jun;40(3):239-242. doi: 10.1080/01676830.2020.1768559. Epub 2020 May 20. PMID: 32431204. Yarmohammadi A, Baxter SL, Ediriwickrema LS, Williams EC, Kobayashi LM, Liu CY, Korn BS, Kikkawa DO. Characterization of Facial Trauma Associated with Standing Electric Scooter Injuries. Ophthalmology. 2020 Jul;127(7):988-990. doi: 10.1016/j.ophtha.2020.02.007. Epub 2020 Feb 14. PMID: 32359837; PMCID: PMC7703691. Long CP, Ediriwickrema LS, Liu CY. Severe Progressive Bilateral Vision Loss With Headaches. JAMA Ophthalmol. 2020 May 1;138(5):582-583. doi: 10.1001/jamaophthalmol.2020.0362. PMID: 32191266. Toomey CB, Protopsaltis NJ, Phou S, Bakhoum MF, Thorson JA, Ediriwickrema LS, Korn BS, Kikkawa DO, Goldbaum MH, Lin JH. PREVALENCE OF MISMATCH REPAIR GENE MUTATIONS IN UVEAL MELANOMA. Retina. 2020 Nov;40(11):2216-2220. doi: 10.1097/IAE.0000000000002732. PMID: 32032254. Men CJ, Ediriwickrema LS, Paik JS, Murdock J, Yen MT, Ng JD, Liu CY, Korn BS, Kikkawa DO. Surgical Intervention of Periocular Infantile Hemangiomas in the Era of β-Blockers. Ophthalmic Plast Reconstr Surg. 2020 Jan/Feb;36(1):70-73. doi: 10.1097/IOP.0000000000001466. PMID: 31809485. Prendes MA, Geng J, Ediriwickrema LS, Areephanthu C, Burchell P, Kikkawa DO, Nunery WR, Korn B, Harold Lee HB. Assessment of the Safety and Efficacy of Prolapsed Orbital Fat Resection During Involutional Entropion Repair. Ophthalmic Plast Reconstr Surg. 2020 Jan/Feb;36(1):34-37. doi: 10.1097/IOP.0000000000001452. PMID: 31567912. Ediriwickrema LS, Liu CY, Kikkawa DO, Korn BS. Development of Poliosis Following Checkpoint Inhibitor Treatment for Cutaneous Melanoma. Ophthalmic Plast Reconstr Surg. 2019 Sep/Oct;35(5):e121-e122. doi: 10.1097/IOP.0000000000001451. PMID: 31373986. Chen TH, Yang PT, Kikkawa DO, Ediriwickrema LS, Afshari NA, Lee JE, Korn BS. A modified technique for bedside amniotic membrane application to the eyelid margins for Stevens-Johnson syndrome. Can J Ophthalmol. 2019 Jun;54(3):e118-e120. doi: 10.1016/j.jcjo.2018.08.020. Epub 2018 Nov 28. PMID: 31109496. Moysidis SN, Koulisis N, Rodger DC, Chao JR, Leng T, de Carlo T, Burkemper B, Ediriwickrema LS, George MS, Jiang Y, Bohm KJ, Gulati S, Torres RJ, Meallet MA, Moshfeghi AA, Flynn HW Jr, Mieler WF, Williams GA, Humayun MS, Eliott D. Thomas A. Swift's Electric Rifle Injuries to the Eye and Ocular Adnexa: The Management of Complex Trauma. Ophthalmol Retina. 2019 Mar;3(3):258-269. doi: 10.1016/j.oret.2018.10.005. Epub 2018 Oct 10. PMID: 31014704. Ediriwickrema LS, Geng J, Nair AA, Prendes M, Gerber AL, Yang PT, Liu CY, Nunery WR, Harold Lee HB, Kikkawa DO, Korn BS. Single Suture Müeller Muscle Conjunctival Resection (ssMMCR): A Modified Technique for Ptosis Repair. Ophthalmic Plast Reconstr Surg. 2019 Jul/Aug;35(4):403-406. doi: 10.1097/IOP.0000000000001380. PMID: 30908466. Ediriwickrema LS, Korn BS, Kikkawa DO. Thyroid-Related Orbitopathy, Restrictive Strabismus, Dermopathy, and Acropachy. JAMA Ophthalmol. 2018 Dec 1;136(12):e183217. doi: 10.1001/jamaophthalmol.2018.3217. Epub 2018 Dec 13. PMID: 30543354. Ediriwickrema LS, Korn BS, Kikkawa DO. Orbital Decompression for Thyroid-Related Orbitopathy During the Quiescent Phase. Ophthalmic Plast Reconstr Surg. 2018 Jul/Aug;34(4S Suppl 1):S90-S97. doi: 10.1097/IOP.0000000000001119. PMID: 29771754. Ediriwickrema LS, Miller NR. Tumors of the Optic Nerve and its Sheath. Int Ophthalmol Clin. 2018 Spring;58(2):237-260. doi: 10.1097/IIO.0000000000000216. PMID: 29517652. Stroh IG, Ediriwickrema LS, Miller NR. Gorham-Stout Disease Presenting as Acute Unilateral Proptosis. J Neuroophthalmol. 2018 Mar;38(1):70-74. doi: 10.1097/WNO.0000000000000569. PMID: 28837441. Liu TYA, Ediriwickrema LS, Vizcaino MA, Wenick A, Miller NR. Optic Nerve Infiltration and Vitreous Seeding by a Cerebral Glioblastoma. JAMA Ophthalmol. 2017 Apr 1;135(4):400-401. doi: 10.1001/jamaophthalmol.2016.5835. PMID: 28208187. 21: Ediriwickrema LS, Chhadva P, Rodger DC, Ameri H, Rao NA. INTRAVENOUS IMMUNOGLOBULIN IN THE TREATMENT OF JUVENILE RETINITIS PIGMENTOSA-ASSOCIATED CYSTOID MACULAR EDEMA AND UVEITIS. Retin Cases Brief Rep. 2018 Summer;12(3):242-246. doi: 10.1097/ICB.0000000000000478. PMID: 27828903. Ediriwickrema LS, Burnstine M, Saber MS, Rao N. Malignant solitary fibrous tumor of the orbit: Spectrum of histologic features. Am J Ophthalmol Case Rep. 2016 Oct 28;5:7-10. doi: 10.1016/j.ajoc.2016.10.007. PMID: 29503937; PMCID: PMC5757752. Zhu D, Berry JL, Ediriwickrema L, Wong K, Lee TC, Murphree AL, Kim JW, Jubran R. Long-Term Outcomes of Group B Eyes in Patients with Retinoblastoma Treated with Short-Course Chemoreduction: Experience from Children's Hospital Los Angeles/University of Southern California. Ocul Oncol Pathol. 2015 Dec;2(2):105-11. doi: 10.1159/000439593. Epub 2015 Nov 5. PMID: 27172535; PMCID: PMC4847672. Samimi DB, Ediriwickrema LS, Bielory BP, Miller D, Lee W, Johnson TE. Microbiology and Biofilm Trends of Silicone Lacrimal Implants: Comparing Infected Versus Routinely Removed Stents. Ophthalmic Plast Reconstr Surg. 2016 Nov/Dec;32(6):452-457. doi: 10.1097/IOP.0000000000000590. PMID: 26588208. Ediriwickrema LS, Francis JH, Arslan-Carlon V, Dalecki PH, Brodie SE, Marr BP, Abramson DH. Intravenous injection of indocyanine green results in an artificial transient desaturation by pulse oximetry. Retin Cases Brief Rep. 2015 Summer;9(3):252-5. doi: 10.1097/ICB.0000000000000152. PMID: 26002141. Ediriwickrema LS, Zaheer W. Diffuse large cell lymphoma presenting as a sacral mass and lupus anticoagulant. Yale J Biol Med. 2011 Dec;84(4):433-8. PMID: 22180680; PMCID: PMC3238310. Polgar O, Ediriwickrema LS, Robey RW, Sharma A, Hegde RS, Li Y, Xia D, Ward Y, Dean M, Ozvegy-Laczka C, Sarkadi B, Bates SE. Arginine 383 is a crucial residue in ABCG2 biogenesis. Biochim Biophys Acta. 2009 Jul;1788(7):1434-43. doi: 10.1016/j.bbamem.2009.04.016. Epub 2009 May 3. PMID: 19406100; PMCID: PMC4163909. Polgar O, Deeken JF, Ediriwickrema LS, Tamaki A, Steinberg SM, Robey RW, Bates SE. The 315-316 deletion determines the BXP-21 antibody epitope but has no effect on the function of wild type ABCG2 or the Q141K variant. Mol Cell Biochem. 2009 Feb;322(1-2):63-71. doi: 10.1007/s11010-008-9940-0. Epub 2008 Nov 11. PMID: 19002564; PMCID: PMC2631614. Vladimir Kefalov, PhD 2016-2022 Poria D, Sun C, Santeford A, Kielar M, Apte R.S., Kisselev O.G., Chen S., Kefalov V.J. (2022) EML1 is essential for retinal photoreceptor migration and survival. Sci Rep. [in prress]. Inamdar S.M., Lankford C.K., Poria D., Laird J.G., Solessio E., Kefalov V.J., Baker S.A. (2021) Differential impact of Kv8.2 loss on rod and cone signaling and degeneration. Hum Mol Genet. doi: 10.1093/hmg/ddab301. [in press]. Laradji A., Karakocak B.B., Kolesnikov A.V., Kefalov V.J., Ravi N. (2021) Hyaluronic acid-based Gold Nanoparticles for the Topical De-livery of Therapeutics to the Retina and the Retinal Pigment Epithelium. Polymers [in press]. Kefalov V.J., Genovese F., Reisert J. (2021) Sensory transduction in photoreceptors and olfactory sensory neurons: common features and distinct characteristics. Front Cell Neurosci | doi: 10.3389/fncel.2021.761416. Laradji A.M., Kolesnikov A.V., Karakoçak B.B., Kefalov V.J., Ravi N. (2021) Redox-Responsive Hyaluronic Acid-Based Nanogels for the Topical Delivery of the Visual Chromophore to Retinal Photoreceptors. ACS Omega. 6:6172-6184. Kolesnikov A.V., Kiser P.D., Palczewski K., Kefalov V.J. (2021) Function of mammalian M-cones depends on the level of CRALBP in Müller cells. J Gen Physiol. 153:e202012675. Bisbach C.M., Hutto R.A., Poria D., Cleghorn W.M., Abbas F., Vinberg F., Kefalov V.J., Hurley J.B., Brockerhoff S.E. (2020) Mitochondrial Calcium Uniporter (MCU) deficiency reveals an alternate path for Ca2+ uptake in photoreceptor mitochondria. Sci Rep. 10:16041. doi: 10.1038/s41598-020-72708-x. Volkov L.I., Kim-Han J., Saunders L., Poria D., Hughes A.E.O., Kefalov V.J., Parichy D.M., Corbo J.C. (2020) Thyroid hormone receptors mediate two distinct mechanisms of long-wavelength vision. Proc Natl Acad Sci U S A. 117:15262-15269. Xue Y., Razafsky D., Hodizc D., Kefalov V.J. (2020) Mislocalization of cone nuclei impairs cone function in mice. FASEB J. 34:10242-10249. Thebeau C., Zhang S., Kolesnikov A.V., Kefalov V.J., Semenkovich C.F., Rajagopal R. (2020) Light deprivation reduces the severity of experimental diabetic retinopathy. Neurobiol Dis. 137:104754. Kolesnikov A.V., Chrispell, J.D., Osawa S., Kefalov V.J. #, Weiss E.R. # (2020) Phosphorylation at Serine 21 in G protein-coupled receptor kinase 1 (GRK1) is required for normal kinetics of dark adaption in rod but not cone photoreceptors. FASEB J. 34:2677-2690 Ruminski D., Palczewska G., Nowakowski M., Zielińska A., Kefalov V.J., Komar K., Palczewski K., Wojtkowski M. (2019) Two-photon microperimetry: sensitivity of human photoreceptors to infrared light. Biomed Opt Express. 10:4551-4567. Vinberg F., Palczewska G., Zhang J., Komar K., Wojtkowski M., Kefalov V.J., Palczewski K. (2019) Sensitivity of Mammalian Cone Photoreceptors to Infrared Light. Neuroscience 416:100-108. Gospe S.M., Travis A.M., Kolesnikov A.V., Klingeborn M., Wang L., Kefalov V.J., Arshavsky V.Y. (2019) Photoreceptors in a Mouse Model of Leigh Syndrome are Capable of Normal Light-Evoked Signaling. J Biol Chem 294:12432-12443. Leinonen H., Choi E.H., Gardella A., Kefalov V.J., Palczewski K., (2019) A mixture of FDA-approved monoaminergic drugs protects the retina from light-damage in diverse models of night blindness. Invest Ophthalmol Vis Sci 60:1442-1453. Kiser P.D., Kolesnikov A.V., Kiser J.Z., Dong Z., Chaurasia B., Wang L., Summers S.A., Hoang T., Blackshaw S., Peachey N.S., Kefalov V.J., Palczewski K. (2019) Conditional deletion of Des1 in the mouse retina does not impair the visual cycle in cones. FASEB J. 33:5782-5792. Sato S., Jastrzebska B., Engel A., Palczewski K., Kefalov V.J. (2019) Apo-opsin exists in equilibrium between a predominant inactive and a rare highly active state. J Neurosci. 39:212-223. Vinberg F., Kefalov V.J. (2018) Investigating the Ca2+-dependent and Ca2+-independent mechanisms for mammalian cone light adaptation. Sci Rep. 8:15864. doi: 10.1038/s41598-018-34073-8. Kolesnikov A.V., Tang P.H., Kefalov V.J. (2018) Examining the Role of Cone-expressed RPE65 in Mouse Cone Function. Sci Rep. 8:14201. doi: 10.1038/s41598-018-32667-w. Vinberg F., Chen J., Kefalov V.J. (2018) Regulation of calcium homeostasis in the outer segments of rod and cone photoreceptors. Prog Retin Eye Res 67:87-101. Vinberg F., Peshenko I.V., Chen J., Dizhoor A.M., Kefalov V.J. (2018) Guanylate cyclase-activating protein 2 contributes to phototransduction and light adaptation in mouse cone photoreceptors. J Biol Chem. 293:7457-7465. Sarria I., Cao Y., Wang Y., Ingram, N.T., Orlandi C., Kamasawa N., Kolesnikov A.V., Kefalov, V.J., Sampath, A.P., Martemyanov, K. (2018) LRIT1 modulates adaptive changes in synaptic communication of cone photoreceptors. Cell Reports 22:3562-3573. Sato S., Peshenko I.V., Olshevskaya E.V., Kefalov V.J.#, Dizhoor A.M.# (2018) GUCY2D Cone-Rod Dystrophy-6 is a 'Phototransduction Disease' Triggered by Abnormal Calcium Feedback on Retinal Membrane Guanylyl Cyclase 1. J Neurosci. 38:2990-3000. Kiser P.D., Zhang J., Sharma A., Angueyra J.M., Kolesnikov A.V., Badiee M., Tochtrop G.P., Kinoshita J., Peachey N.S., Li W., Kefalov V.J.#, Palczewski K.# (2018) Retinoid isomerase inhibitors impair but do not block mammalian cone photoreceptor function. J Gen Physiol. 150:571-590. Kolesnikov A.V., Orban T., Jin H., Brooks C., Hofmann L., Dong Z., Sokolov M., Palczewski K.#, Kefalov V.J.# (2017) Dephosphorylation by protein phosphatase 2A regulates visual pigment regeneration and the dark adaptation of mammalian photoreceptors. Proc Natl Acad Sci U S A. 114:E9675-E9684. Vinberg F., Wang T., De Maria A., Zhao H., Bassnett S., Chen J.#, Kefalov V.J.# (2017) The Na+/Ca2+, K+ exchanger NCKX4 is required for efficient cone-mediated vision. Elife 6: doi: 10.7554/eLife.24550. Potter C., Zhu W., Razafsky D., Ruzycki P., Kolesnikov A.V., Doggett T., Kefalov V.J., Betleja E., Mahjoub M.R., Hodzic D. (2017) Multiple Isoforms of Nesprin1 Are Integral Components of Ciliary Rootlets. Curr Biol 27:2014-2022. Xue Y., Sato S., Razafsky D., Sahu B., Shen S.Q., Potter C., Sandell L.L., Corbo J.C., Palczewski K., Maeda A., Hodzic D., Kefalov V.J. (2017) The role of retinol dehydrogenase 10 in the cone visual cycle. Sci Rep 7: doi: 10.1038/s41598-017-02549-8. Sato S., Frederiksen R., Cornwall M.C., Kefalov V.J. (2017) The retina visual cycle is driven by cis retinol oxidation in the outer segments of cones. Vis Neurosci 34: doi: 10.1017/S0952523817000013. Sato S, Kefalov VJ. (2016) cis Retinol oxidation regulates photoreceptor access to the retina visual cycle and cone pigment regeneration. J Physiol. 594(22):6753-6765. Sakurai K, Vinberg F, Wang T, Chen J, Kefalov VJ. (2016) The Na+/Ca2+, K+ exchanger 2 modulates mammalian cone phototransduction. Sci Rep 6:32521. doi: 10.1038/srep32521. Ding X.Q., Thapa A., Ma H., Xu J., Elliott M.H., Rodgers K.K., Smith M.L., Wang J.S., Pittler S.J., Kefalov V.J. 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J Biol Chem. 2014;289(18):12286-99. doi: 10.1074/jbc.M114.552836. PubMed PMID: 24648526; PMCID: PMC4007427. Kiser PD, Golczak M, Palczewski K. Chemistry of the retinoid (visual) cycle. Chem Rev. 2014;114(1):194-232. doi: 10.1021/cr400107q. PubMed PMID: 23905688; PMCID: PMC3858459. Chen Y, Tang H, Seibel W, Papoian R, Oh K, Li X, Zhang J, Golczak M, Palczewski K, Kiser PD. Identification and characterization of novel inhibitors of Mammalian aspartyl aminopeptidase. Mol Pharmacol. 2014;86(2):231-42. doi: 10.1124/mol.114.093070. PubMed PMID: 24913940; PMCID: PMC4127928. Kowatz T, Babino D, Kiser P, Palczewski K, von Lintig J. Characterization of human beta,beta-carotene-15,15'-monooxygenase (BCMO1) as a soluble monomeric enzyme. Arch Biochem Biophys. 2013;539(2):214-22. doi: 10.1016/j.abb.2013.05.007. PubMed PMID: 23727499; PMCID: PMC3795993. Sui X, Kiser PD, Lintig J, Palczewski K. Structural basis of carotenoid cleavage: from bacteria to mammals. Arch Biochem Biophys. 2013;539(2):203-13. doi: 10.1016/j.abb.2013.06.012. PubMed PMID: 23827316; PMCID: PMC3818509. Palczewski K, Kiser PD. Biochemistry. As good as chocolate. Science. 2013;340(6132):562-3. doi: 10.1126/science.1238521. PubMed PMID: 23641106; PMCID: PMC4596528. Kiser PD, Farquhar ER, Shi W, Sui X, Chance MR, Palczewski K. Structure of RPE65 isomerase in a lipidic matrix reveals roles for phospholipids and iron in catalysis. Proc Natl Acad Sci USA. 2012;109(41):E2747-56. doi: 10.1073/pnas.1212025109. PubMed PMID: 23012475; PMCID: PMC3478654. Golczak M, Kiser PD, Sears AE, Lodowski DT, Blaner WS, Palczewski K. Structural basis for the acyltransferase activity of lecithin:retinol acyltransferase-like proteins. J Biol Chem. 2012;287(28):23790-807. doi: 10.1074/jbc.M112.361550. PubMed PMID: 22605381; PMCID: PMC3390653. Kiser PD, Golczak M, Maeda A, Palczewski K. Key enzymes of the retinoid (visual) cycle in vertebrate retina. Biochim Biophys Acta. 2012;1821(1):137-51. doi: 10.1016/j.bbalip.2011.03.005. PubMed PMID: 21447403; PMCID: PMC3158816. Chen Y, Farquhar ER, Chance MR, Palczewski K, Kiser PD. Insights into substrate specificity and metal activation of mammalian tetrahedral aspartyl aminopeptidase. J Biol Chem. 2012;287(16):13356-70. doi: 10.1074/jbc.M112.347518. PubMed PMID: 22356908; PMCID: PMC3339940. Kiser PD, Palczewski K. Membrane-binding and enzymatic properties of RPE65. Prog Retin Eye Res. 2010;29(5):428-42. doi: 10.1016/j.preteyeres.2010.03.002. PubMed PMID: 20304090; PMCID: PMC2903629. Golczak M, Kiser PD, Lodowski DT, Maeda A, Palczewski K. Importance of membrane structural integrity for RPE65 retinoid isomerization activity. J Biol Chem. 2010;285(13):9667-82. doi: 10.1074/jbc.M109.063941. PubMed PMID: 20100834; PMCID: PMC2843217. von Lintig J, Kiser PD, Golczak M, Palczewski K. The biochemical and structural basis for trans-to-cis isomerization of retinoids in the chemistry of vision. Trends Biochem Sci. 2010;35(7):400-10. doi: 10.1016/j.tibs.2010.01.005. PubMed PMID: 20188572; PMCID: PMC2891588. Bereta G, Wang B, Kiser PD, Baehr W, Jang GF, Palczewski K. A functional kinase homology domain is essential for the activity of photoreceptor guanylate cyclase 1. J Biol Chem. 2010;285(3):1899-908. doi: 10.1074/jbc.M109.061713. PubMed PMID: 19901021; PMCID: PMC2804348. Kiser PD, Golczak M, Lodowski DT, Chance MR, Palczewski K. Crystal structure of native RPE65, the retinoid isomerase of the visual cycle. Proc Natl Acad Sci USA. 2009;106(41):17325-30. doi: 10.1073/pnas.0906600106. PubMed PMID: 19805034; PMCID: PMC2765077. Kiser PD, Lorimer GH, Palczewski K. Use of thallium to identify monovalent cation binding sites in GroEL. Acta Crystallographica Section F. 2009;65(Pt 10):967-71. doi: 10.1107/S1744309109032928. PubMed PMID: 19851000; PMCID: PMC2765879. Bereta G, Kiser PD, Golczak M, Sun W, Heon E, Saperstein DA, Palczewski K. 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Regenerating Skeletal Muscle Compensates for the Impaired Macrophage Functions Leading to Normal Muscle Repair in Retinol Saturase Null Mice. Cells. 2022 Apr 13;11(8):1333. doi: 10.3390/cells11081333.PMID: 35456012 Chen S, Getter T, Salom D, Wu D, Quetschlich D, Chorev DS, Palczewski K, Robinson CV. Capturing a rhodopsin receptor signalling cascade across a native membrane. Nature. 2022 Apr;604(7905):384-390. doi: 10.1038/s41586-022-04547-x. Epub 2022 Apr 6.PMID: 35388214 Choi EH, Suh S, Foik AT, Leinonen H, Newby GA, Gao XD, Banskota S, Hoang T, Du SW, Dong Z, Raguram A, Kohli S, Blackshaw S, Lyon DC, Liu DR, Palczewski K. In vivo base editing rescues cone photoreceptors in a mouse model of early-onset inherited retinal degeneration. Nat Commun. 2022 Apr 5;13(1):1830. doi: 10.1038/s41467-022-29490-3.PMID: 35383196 Banskota S, Raguram A, Suh S, Du SW, Davis JR, Choi EH, Wang X, Nielsen SC, Newby GA, Randolph PB, Osborn MJ, Musunuru K, Palczewski K, Liu DR. Engineered virus-like particles for efficient in vivo delivery of therapeutic proteins. Cell. 2022 Jan 20;185(2):250-265.e16. doi: 10.1016/j.cell.2021.12.021. Epub 2022 Jan 11.PMID: 35021064 Lewandowski D, Foik AT, Smidak R, Choi EH, Zhang J, Hoang T, Tworak A, Suh S, Leinonen H, Dong Z, Pinto AF, Tom E, Luu J, Lee J, Ma X, Bieberich E, Blackshaw S, Saghatelian A, Lyon DC, Skowronska-Krawczyk D, Tabaka M, Palczewski K. Inhibition of ceramide accumulation in AdipoR1-/- mice increases photoreceptor survival and improves vision. JCI Insight. 2022 Feb 22;7(4):e156301. doi: 10.1172/jci.insight.156301.PMID: 35015730 Cheng C, Weiss L, Leinonen H, Shmara A, Yin HZ, Ton T, Do A, Lee J, Ta L, Mohanty E, Vargas J, Weiss J, Palczewski K, Kimonis V. VCP/p97 inhibitor CB-5083 modulates muscle pathology in a mouse model of VCP inclusion body myopathy. J Transl Med. 2022 Jan 8;20(1):21. doi: 10.1186/s12967-021-03186-6.PMID: 34998409 Pöge M, Mahamid J, Imanishi SS, Plitzko JM, Palczewski K, Baumeister W. Determinants shaping the nanoscale architecture of the mouse rod outer segment. Elife. 2021 Dec 21;10:e72817. doi: 10.7554/eLife.72817.PMID: 34931611 Boguslawski J, Palczewska G, Tomczewski S, Milkiewicz J, Kasprzycki P, Stachowiak D, Komar K, Marzejon MJ, Sikorski BL, Hudzikowski A, Głuszek A, Łaszczych Z, Karnowski K, Soboń G, Palczewski K, Wojtkowski M. In vivo imaging of the human eye using a 2-photon-exd fluorescence scanning laser ophthalmoscope. J Clin Invest. 2022 Jan 18;132(2):e154218. doi: 10.1172/JCI154218.PMID: 34847075 Getter T, Kemp A, Vinberg F, Palczewski K. Identification of small-molecule allosteric modulators that act as enhancers/disrupters of rhodopsin oligomerization. J Biol Chem. 2021 Dec;297(6):101401. doi: 10.1016/j.jbc.2021.101401. Epub 2021 Nov 11.PMID: 34774799 Du SW, Palczewski K. MicroRNA regulation of critical retinal pigment epithelial functions. Trends Neurosci. 2022 Jan;45(1):78-90. doi: 10.1016/j.tins.2021.10.008. Epub 2021 Nov 6.PMID: 34753606 Review. Occelli LM, Daruwalla A, De Silva SR, Winkler PA, Sun K, Pasmanter N, Minella A, Querubin J, Lyons LA; 99 Lives Consortium, Robson AG, Heon E, Michaelides M, Webster AR, Palczewski K, Vincent A, Mahroo OA, Kiser PD, Petersen-Jones SM. A large animal model of RDH5-associated retinopathy recapitulates important features of the human phenotype. Hum Mol Genet. 2022 Apr 22;31(8):1263-1277. doi: 10.1093/hmg/ddab316.PMID: 34726233 Sander CL, Luu J, Kim K, Furkert D, Jang K, Reichenwallner J, Kang M, Lee HJ, Eger BT, Choe HW, Fiedler D, Ernst OP, Kim YJ, Palczewski K, Kiser PD. Structural evidence for visual arrestin priming via complexation of phosphoinositols. Structure. 2022 Feb 3;30(2):263-277.e5. doi: 10.1016/j.str.2021.10.002. Epub 2021 Oct 21.PMID: 34678158 Kochman MA, Palczewski K, Kubas A. Theoretical Study of the Photoisomerization Mechanism of All-Trans-Retinyl Acetate. J Phys Chem A. 2021 Sep 30;125(38):8358-8372. doi: 10.1021/acs.jpca.1c05533. Epub 2021 Sep 21.PMID: 34546761 Kern TS, Du Y, Tang J, Lee CA, Liu H, Dreffs A, Leinonen H, Antonetti DA, Palczewski K. Regulation of Adrenergic, Serotonin, and Dopamine Receptors to Inhibit Diabetic Retinopathy: Monotherapies versus Combination Therapies. Mol Pharmacol. 2021 Nov;100(5):470-479. doi: 10.1124/molpharm.121.000278. Epub 2021 Aug 15.PMID: 34393108 Sander CL, Sears AE, Pinto AFM, Choi EH, Kahremany S, Gao F, Salom D, Jin H, Pardon E, Suh S, Dong Z, Steyaert J, Saghatelian A, Skowronska-Krawczyk D, Kiser PD, Palczewski K. Nano-scale resolution of native retinal rod disk membranes reveals differences in lipid composition. J Cell Biol. 2021 Aug 2;220(8):e202101063. doi: 10.1083/jcb.202101063. Epub 2021 Jun 16.PMID: 34132745 Blum E, Zhang J, Zaluski J, Einstein DE, Korshin EE, Kubas A, Gruzman A, Tochtrop GP, Kiser PD, Palczewski K. Rational Alteration of Pharmacokinetics of Chiral Fluorinated and Deuterated Derivatives of Emixustat for Retinal Therapy. J Med Chem. 2021 Jun 24;64(12):8287-8302. doi: 10.1021/acs.jmedchem.1c00279. Epub 2021 Jun 3.PMID: 34081480 Gulati S, Palczewski K. New focus on regulation of the rod photoreceptor phosphodiesterase. Curr Opin Struct Biol. 2021 Aug;69:99-107. doi: 10.1016/j.sbi.2021.03.016. Epub 2021 May 1.PMID: 33945959 Review. Leinonen H, Cheng C, Pitkänen M, Sander CL, Zhang J, Saeid S, Turunen T, Shmara A, Weiss L, Ta L, Ton T, Koskelainen A, Vargas JD, Kimonis V, Palczewski K. A p97/Valosin-Containing Protein Inhibitor Drug CB-5083 Has a Potent but Reversible Off-Target Effect on Phosphodiesterase-6. J Pharmacol Exp Ther. 2021 Jul;378(1):31-41. doi: 10.1124/jpet.120.000486. 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Biomed Opt Express. 2020 Dec 17;12(1):462-479. doi: 10.1364/BOE.411168. eCollection 2021 Jan 1.PMID: 33659083 Sun D, Sun W, Gao SQ, Wei C, Naderi A, Schilb AL, Scheidt J, Lee S, Kern TS, Palczewski K, Lu ZR. Formulation and efficacy of ECO/pRHO-ABCA4-SV40 nanoparticles for nonviral gene therapy of Stargardt disease in a mouse model. J Control Release. 2021 Feb 10;330:329-340. doi: 10.1016/j.jconrel.2020.12.010. Epub 2020 Dec 21.PMID: 33358976 Łabuz G, Rayamajhi A, Khoramnia R, Palczewska G, Palczewski K, Holschbach A, Auffarth GU. THE LOSS OF INFRARED LIGHT SENSITIVITY OF PHOTORECEPTOR CELLS MEASURED WITH TWO-PHOTON EXCITATION AS AN INDICATOR OF DIABETIC RETINOPATHY: A Pilot Study. Retina. 2021 Jun 1;41(6):1302-1308. doi: 10.1097/IAE.0000000000003032.PMID: 33323904 Kolesnikov AV, Kiser PD, Palczewski K, Kefalov VJ. Function of mammalian M-cones depends on the level of CRALBP in Müller cells. J Gen Physiol. 2021 Jan 4;153(1):e202012675. doi: 10.1085/jgp.202012675.PMID: 33216847 Kiser PD, Palczewski K. Pathways and disease-causing alterations in visual chromophore production for vertebrate vision. J Biol Chem. 2021 Jan-Jun;296:100072. doi: 10.1074/jbc.REV120.014405. Epub 2020 Nov 23.PMID: 33187985 2018-2020 Suh S, Choi EH, Leinonen H, Foik AT, Newby GA, Yeh WH, Dong Z, Kiser PD, Lyon DC, Liu DR, Palczewski K. Publisher Correction: Restoration of visual function in adult mice with an inherited retinal disease via adenine base editing. Nat Biomed Eng. 2020 Nov;4(11):1119. doi: 10.1038/s41551-020-00652-2.PMID: 33122854 Suh S, Choi EH, Leinonen H, Foik AT, Newby GA, Yeh WH, Dong Z, Kiser PD, Lyon DC, Liu DR, Palczewski K. Restoration of visual function in adult mice with an inherited retinal disease via adenine base editing. Nat Biomed Eng. 2021 Feb;5(2):169-178. doi: 10.1038/s41551-020-00632-6. Epub 2020 Oct 19.PMID: 33077938 Leinonen H, Pham NC, Boyd T, Santoso J, Palczewski K, Vinberg F. Homeostatic plasticity in the retina is associated with maintenance of night vision during retinal degenerative disease. Elife. 2020 Sep 22;9:e59422. doi: 10.7554/eLife.59422.PMID: 32960171 Sears AE, Albiez S, Gulati S, Wang B, Kiser P, Kovacik L, Engel A, Stahlberg H, Palczewski K. Single particle cryo-EM of the complex between interphotoreceptor retinoid-binding protein and a monoclonal antibody. FASEB J. 2020 Oct;34(10):13918-13934. doi: 10.1096/fj.202000796RR. Epub 2020 Aug 28.PMID: 32860273 Łabuz G, Rayamajhi A, Usinger J, Komar K, Merz P, Khoramnia R, Palczewska G, Palczewski K, Auffarth GU. Clinical Application of Infrared-Light Microperimetry in the Assessment of Scotopic-Eye Sensitivity. 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Stable Retinoid Analogue Targeted Dual pH-Sensitive Smart Lipid ECO/pDNA Nanoparticles for Specific Gene Delivery in the Retinal Pigment Epithelium. ACS Appl Bio Mater. 2020 May 18;3(5):3078-3086. doi: 10.1021/acsabm.0c00130. Epub 2020 Apr 3.PMID: 34327311 No abstract available. Corral-Serrano JC, Lamers IJC, van Reeuwijk J, Duijkers L, Hoogendoorn ADM, Yildirim A, Argyrou N, Ruigrok RAA, Letteboer SJF, Butcher R, van Essen MD, Sakami S, van Beersum SEC, Palczewski K, Cheetham ME, Liu Q, Boldt K, Wolfrum U, Ueffing M, Garanto A, Roepman R, Collin RWJ. PCARE and WASF3 regulate ciliary F-actin assembly that is required for the initiation of photoreceptor outer segment disk formation. Proc Natl Acad Sci U S A. 2020 May 5;117(18):9922-9931. doi: 10.1073/pnas.1903125117. Epub 2020 Apr 20.PMID: 32312818 Valdez-Lopez JC, Gulati S, Ortiz EA, Palczewski K, Robinson PR. Melanopsin Carboxy-terminus phosphorylation plasticity and bulk negative charge, not strict site specificity, achieves phototransduction deactivation. PLoS One. 2020 Apr 1;15(4):e0228121. doi: 10.1371/journal.pone.0228121. eCollection 2020.PMID: 32236094 Sarang Z, Sághy T, Budai Z, Ujlaky-Nagy L, Bedekovics J, Beke L, Méhes G, Nagy G, Rühl R, Moise AR, Palczewski K, Szondy Z. Retinol Saturase Knock-Out Mice are Characterized by Impaired Clearance of Apoptotic Cells and Develop Mild Autoimmunity. Biomolecules. 2019 Nov 13;9(11):737. doi: 10.3390/biom9110737.PMID: 31766264 Zhang J, Choi EH, Tworak A, Salom D, Leinonen H, Sander CL, Hoang TV, Handa JT, Blackshaw S, Palczewska G, Kiser PD, Palczewski K. Photic generation of 11-cis-retinal in bovine retinal pigment epithelium. J Biol Chem. 2019 Dec 13;294(50):19137-19154. doi: 10.1074/jbc.RA119.011169. Epub 2019 Nov 6.PMID: 31694912 Kallestad L, Blackshaw S, Khalil AM, Palczewski K. Tissue- and Species-Specific Patterns of RNA metabolism in Post-Mortem Mammalian Retina and Retinal Pigment Epithelium. Sci Rep. 2019 Oct 15;9(1):14821. doi: 10.1038/s41598-019-51379-3.PMID: 31616038 Sun D, Schur RM, Sears AE, Gao SQ, Vaidya A, Sun W, Maeda A, Kern T, Palczewski K, Lu ZR. Non-viral Gene Therapy for Stargardt Disease with ECO/pRHO-ABCA4 Self-Assembled Nanoparticles. Mol Ther. 2020 Jan 8;28(1):293-303. doi: 10.1016/j.ymthe.2019.09.010. Epub 2019 Sep 12.PMID: 31611143 Ruminski D, Palczewska G, Nowakowski M, Zielińska A, Kefalov VJ, Komar K, Palczewski K, Wojtkowski M. Two-photon microperimetry: sensitivity of human photoreceptors to infrared light. Biomed Opt Express. 2019 Aug 9;10(9):4551-4567. doi: 10.1364/BOE.10.004551. eCollection 2019 Sep 1.PMID: 31565509 Kahremany S, Sander CL, Tochtrop GP, Kubas A, Palczewski K. Z-isomerization of retinoids through combination of monochromatic photoisomerization and metal catalysis. Org Biomol Chem. 2019 Sep 21;17(35):8125-8139. doi: 10.1039/c9ob01645g. Epub 2019 Aug 28.PMID: 31455964 Vinberg F, Palczewska G, Zhang J, Komar K, Wojtkowski M, Kefalov VJ, Palczewski K. Sensitivity of Mammalian Cone Photoreceptors to Infrared Light. Neuroscience. 2019 Sep 15;416:100-108. doi: 10.1016/j.neuroscience.2019.07.047. Epub 2019 Aug 7.PMID: 31400484 Zhao DY, Pöge M, Morizumi T, Gulati S, Van Eps N, Zhang J, Miszta P, Filipek S, Mahamid J, Plitzko JM, Baumeister W, Ernst OP, Palczewski K. Cryo-EM structure of the native rhodopsin dimer in nanodiscs. J Biol Chem. 2019 Sep 27;294(39):14215-14230. doi: 10.1074/jbc.RA119.010089. Epub 2019 Aug 9.PMID: 31399513 Kahremany S, Kubas A, Tochtrop GP, Palczewski K. Catalytic synthesis of 9-cis-retinoids: mechanistic insights. Dalton Trans. 2019 Jul 16;48(28):10581-10595. doi: 10.1039/c9dt02189b.PMID: 31218312 Getter T, Gulati S, Zimmerman R, Chen Y, Vinberg F, Palczewski K. Stereospecific modulation of dimeric rhodopsin. FASEB J. 2019 Aug;33(8):9526-9539. doi: 10.1096/fj.201900443RR. Epub 2019 May 23.PMID: 31121099 Mustafi D, Arbabi A, Ameri H, Palczewski K. Retinal Gene Distribution and Functionality Implicated in Inherited Retinal Degenerations Can Reveal Disease-Relevant Pathways for Pharmacologic Intervention. Pharmaceuticals (Basel). 2019 May 17;12(2):74. doi: 10.3390/ph12020074.PMID: 31108889 Getter T, Suh S, Hoang T, Handa JT, Dong Z, Ma X, Chen Y, Blackshaw S, Palczewski K. The selective estrogen receptor modulator raloxifene mitigates the effect of all-trans-retinal toxicity in photoreceptor degeneration. J Biol Chem. 2019 Jun 14;294(24):9461-9475. doi: 10.1074/jbc.RA119.008697. Epub 2019 May 9.PMID: 31073029 Liu H, Tang J, Du Y, Saadane A, Samuels I, Veenstra A, Kiser JZ, Palczewski K, Kern TS. Transducin1, Phototransduction and the Development of Early Diabetic Retinopathy. Invest Ophthalmol Vis Sci. 2019 Apr 1;60(5):1538-1546. doi: 10.1167/iovs.18-26433.PMID: 30994864 Salom D, Jin H, Gerken TA, Yu C, Huang L, Palczewski K. Human red and green cone opsins are O-glycosylated at an N-terminal Ser/Thr-rich domain conserved in vertebrates. J Biol Chem. 2019 May 17;294(20):8123-8133. doi: 10.1074/jbc.RA118.006835. Epub 2019 Apr 4.PMID: 30948514 Leinonen H, Choi EH, Gardella A, Kefalov VJ, Palczewski K. A Mixture of U.S. Food and Drug Administration-Approved Monoaminergic Drugs Protects the Retina From Light Damage in Diverse Models of Night Blindness. Invest Ophthalmol Vis Sci. 2019 Apr 1;60(5):1442-1453. doi: 10.1167/iovs.19-26560.PMID: 30947334 Gulati S, Palczewski K, Engel A, Stahlberg H, Kovacik L. Cryo-EM structure of phosphodiesterase 6 reveals insights into the allosteric regulation of type I phosphodiesterases. Sci Adv. 2019 Feb 27;5(2):eaav4322. doi: 10.1126/sciadv.aav4322. eCollection 2019 Feb.PMID: 30820458 Katayama K, Gulati S, Ortega JT, Alexander NS, Sun W, Shenouda MM, Palczewski K, Jastrzebska B. Specificity of the chromophore-binding site in human cone opsins. J Biol Chem. 2019 Apr 12;294(15):6082-6093. doi: 10.1074/jbc.RA119.007587. Epub 2019 Feb 15.PMID: 30770468 Kiser PD, Kolesnikov AV, Kiser JZ, Dong Z, Chaurasia B, Wang L, Summers SA, Hoang T, Blackshaw S, Peachey NS, Kefalov VJ, Palczewski K. Conditional deletion of Des1 in the mouse retina does not impair the visual cycle in cones. FASEB J. 2019 Apr;33(4):5782-5792. doi: 10.1096/fj.201802493R. Epub 2019 Jan 15.PMID: 30645148 Sakami S, Imanishi Y, Palczewski K. Müller glia phagocytose dead photoreceptor cells in a mouse model of retinal degenerative disease. FASEB J. 2019 Mar;33(3):3680-3692. doi: 10.1096/fj.201801662R. Epub 2018 Nov 21.PMID: 30462532 Sato S, Jastrzebska B, Engel A, Palczewski K, Kefalov VJ. Apo-Opsin Exists in Equilibrium Between a Predominant Inactive and a Rare Highly Active State. J Neurosci. 2019 Jan 9;39(2):212-223. doi: 10.1523/JNEUROSCI.1980-18.2018. Epub 2018 Nov 20.PMID: 30459230 Daruwalla A, Choi EH, Palczewski K, Kiser PD. Structural biology of 11-cis-retinaldehyde production in the classical visual cycle. Biochem J. 2018 Oct 22;475(20):3171-3188. doi: 10.1042/BCJ20180193.PMID: 30352831 Review. Palczewska G, Kern TS, Palczewski K. Noninvasive Two-Photon Microscopy Imaging of Mouse Retina and Retinal Pigment Epithelium. Methods Mol Biol. 2019;1834:333-343. doi: 10.1007/978-1-4939-8669-9_21.PMID: 30324453 Sakami S, Palczewski K. Immuno-TEM/STEM in Retinal Research. Methods Mol Biol. 2019;1834:311-332. doi: 10.1007/978-1-4939-8669-9_20.PMID: 30324452 Chan HCS, Wang J, Palczewski K, Filipek S, Vogel H, Liu ZJ, Yuan S. Exploring a new ligand binding site of G protein-coupled receptors. Chem Sci. 2018 Jul 13;9(31):6480-6489. doi: 10.1039/c8sc01680a. eCollection 2018 Aug 21.PMID: 30310578 Behnen P, Felline A, Comitato A, Di Salvo MT, Raimondi F, Gulati S, Kahremany S, Palczewski K, Marigo V, Fanelli F. A Small Chaperone Improves Folding and Routing of Rhodopsin Mutants Linked to Inherited Blindness. iScience. 2018 Jun 29;4:1-19. doi: 10.1016/j.isci.2018.05.001. Epub 2018 May 5.PMID: 30240733 Palczewska G, Stremplewski P, Suh S, Alexander N, Salom D, Dong Z, Ruminski D, Choi EH, Sears AE, Kern TS, Wojtkowski M, Palczewski K. Two-photon imaging of the mammalian retina with ultrafast pulsing laser. JCI Insight. 2018 Sep 6;3(17):e121555. doi: 10.1172/jci.insight.121555. eCollection 2018 Sep 6.PMID: 30185665 Gao S, Parmar T, Palczewska G, Dong Z, Golczak M, Palczewski K, Jastrzebska B. Protective Effect of a Locked Retinal Chromophore Analog against Light-Induced Retinal Degeneration. Mol Pharmacol. 2018 Oct;94(4):1132-1144. doi: 10.1124/mol.118.112581. Epub 2018 Jul 17.PMID: 30018116 Gulati S, Jin H, Masuho I, Orban T, Cai Y, Pardon E, Martemyanov KA, Kiser PD, Stewart PL, Ford CP, Steyaert J, Palczewski K. Targeting G protein-coupled receptor signaling at the G protein level with a selective nanobody inhibitor. Nat Commun. 2018 May 18;9(1):1996. doi: 10.1038/s41467-018-04432-0.PMID: 29777099 Chen Y, Chen Y, Jastrzebska B, Golczak M, Gulati S, Tang H, Seibel W, Li X, Jin H, Han Y, Gao S, Zhang J, Liu X, Heidari-Torkabadi H, Stewart PL, Harte WE, Tochtrop GP, Palczewski K. A novel small molecule chaperone of rod opsin and its potential therapy for retinal degeneration. Nat Commun. 2018 May 17;9(1):1976. doi: 10.1038/s41467-018-04261-1.PMID: 29773803 Choi EH, Suh S, Sander CL, Hernandez CJO, Bulman ER, Khadka N, Dong Z, Shi W, Palczewski K, Kiser PD. Insights into the pathogenesis of dominant retinitis pigmentosa associated with a D477G mutation in RPE65. Hum Mol Genet. 2018 Jul 1;27(13):2225-2243. doi: 10.1093/hmg/ddy128.PMID: 29659842 Trifonov L, Afri M, Palczewski K, Korshin EE, Gruzman A. An Expedient Synthesis of CMF-019: (S)-5-Methyl-3-{1-(pentan-3-yl)-2- (thiophen-2-ylmethyl)-1H-benzo[d]imidazole-5-carboxamido}hexanoic Acid, a Potent Apelin Receptor (APJ) Agonist. Med Chem. 2018;14(7):688-694. doi: 10.2174/1573406414666180412154952.PMID: 29651942 Kiser PD, Zhang J, Sharma A, Angueyra JM, Kolesnikov AV, Badiee M, Tochtrop GP, Kinoshita J, Peachey NS, Li W, Kefalov VJ, Palczewski K. Retinoid isomerase inhibitors impair but do not block mammalian cone photoreceptor function. J Gen Physiol. 2018 Apr 2;150(4):571-590. doi: 10.1085/jgp.201711815. Epub 2018 Mar 2.PMID: 29500274 Luu J, Palczewski K. Human aging and disease: Lessons from age-related macular degeneration. Proc Natl Acad Sci U S A. 2018 Mar 20;115(12):2866-2872. doi: 10.1073/pnas.1721033115. Epub 2018 Feb 26.PMID: 29483257 Gao S, Kahremany S, Zhang J, Jastrzebska B, Querubin J, Petersen-Jones SM, Palczewski K. Retinal-chitosan Conjugates Effectively Deliver Active Chromophores to Retinal Photoreceptor Cells in Blind Mice and Dogs. Mol Pharmacol. 2018 May;93(5):438-452. doi: 10.1124/mol.117.111294. Epub 2018 Feb 16.PMID: 29453250 Schur RM, Gao S, Yu G, Chen Y, Maeda A, Palczewski K, Lu ZR. New GABA modulators protect photoreceptor cells from light-induced degeneration in mouse models. FASEB J. 2018 Jun;32(6):3289-3300. doi: 10.1096/fj.201701250R. Epub 2018 Jan 24.PMID: 29401616 Owen TS, Salom D, Sun W, Palczewski K. Increasing the Stability of Recombinant Human Green Cone Pigment. Biochemistry. 2018 Feb 13;57(6):1022-1030. doi: 10.1021/acs.biochem.7b01118. Epub 2018 Jan 29.PMID: 29320632 2014-2017 Murashova GA, Mancuso CA, Canfield JL, Sakami S, Palczewski K, Palczewska G, Dantus M. Multimodal nonlinear optical imaging of unstained retinas in the epi-direction with a sub-40 fs Yb-fiber laser. Biomed Opt Express. 2017 Oct 26;8(11):5228-5242. doi: 10.1364/BOE.8.005228. eCollection 2017 Nov 1.PMID: 29188116 Orban T, Leinonen H, Getter T, Dong Z, Sun W, Gao S, Veenstra A, Heidari-Torkabadi H, Kern TS, Kiser PD, Palczewski K. A Combination of G Protein-Coupled Receptor Modulators Protects Photoreceptors from Degeneration. J Pharmacol Exp Ther. 2018 Feb;364(2):207-220. doi: 10.1124/jpet.117.245167. Epub 2017 Nov 21.PMID: 29162627 Penberthy KK, Rival C, Shankman LS, Raymond MH, Zhang J, Perry JSA, Lee CS, Han CZ, Onengut-Gumuscu S, Palczewski K, Lysiak JJ, Ravichandran KS. Context-dependent compensation among phosphatidylserine-recognition receptors. Sci Rep. 2017 Nov 7;7(1):14623. doi: 10.1038/s41598-017-15191-1.PMID: 29116131 Kolesnikov AV, Orban T, Jin H, Brooks C, Hofmann L, Dong Z, Sokolov M, Palczewski K, Kefalov VJ. Dephosphorylation by protein phosphatase 2A regulates visual pigment regeneration and the dark adaptation of mammalian photoreceptors. Proc Natl Acad Sci U S A. 2017 Nov 7;114(45):E9675-E9684. doi: 10.1073/pnas.1712405114. Epub 2017 Oct 23.PMID: 29078372 Murashova GA, Mancuso CA, Sakami S, Palczewski K, Palczewska G, Dantus M. Epi-direction detected multimodal imaging of an unstained mouse retina with a Yb-fiber laser. Proc SPIE Int Soc Opt Eng. 2017 Mar;10069:100692K. doi: 10.1117/12.2252457.PMID: 28989217 Chiang CK, Tworak A, Kevany BM, Xu B, Mayne J, Ning Z, Figeys D, Palczewski K. Quantitative phosphoproteomics reveals involvement of multiple signaling pathways in early phagocytosis by the retinal pigmented epithelium. J Biol Chem. 2017 Dec 1;292(48):19826-19839. doi: 10.1074/jbc.M117.812677. Epub 2017 Oct 4.PMID: 28978645 Chan HCS, McCarthy D, Li J, Palczewski K, Yuan S. Designing Safer Analgesics via μ-Opioid Receptor Pathways. Trends Pharmacol Sci. 2017 Nov;38(11):1016-1037. doi: 10.1016/j.tips.2017.08.004. Epub 2017 Sep 19.PMID: 28935293 Review. Sears AE, Bernstein PS, Cideciyan AV, Hoyng C, Charbel Issa P, Palczewski K, Rosenfeld PJ, Sadda S, Schraermeyer U, Sparrow JR, Washington I, Scholl HPN. Towards Treatment of Stargardt Disease: Workshop Organized and Sponsored by the Foundation Fighting Blindness. Transl Vis Sci Technol. 2017 Sep 14;6(5):6. doi: 10.1167/tvst.6.5.6. eCollection 2017 Sep.PMID: 28920007 Review. Alexander NS, Palczewski K. Crowd sourcing difficult problems in protein science. Protein Sci. 2017 Nov;26(11):2118-2125. doi: 10.1002/pro.3247. Epub 2017 Aug 29.PMID: 28762619 Review. Tonade D, Liu H, Palczewski K, Kern TS. Photoreceptor cells produce inflammatory products that contribute to retinal vascular permeability in a mouse model of diabetes. Diabetologia. 2017 Oct;60(10):2111-2120. doi: 10.1007/s00125-017-4381-5. Epub 2017 Jul 28.PMID: 28755268 Sun D, Sahu B, Gao S, Schur RM, Vaidya AM, Maeda A, Palczewski K, Lu ZR. Targeted Multifunctional Lipid ECO Plasmid DNA Nanoparticles as Efficient Non-viral Gene Therapy for Leber's Congenital Amaurosis. Mol Ther Nucleic Acids. 2017 Jun 16;7:42-52. doi: 10.1016/j.omtn.2017.02.005. Epub 2017 Feb 28.PMID: 28624218 Xue Y, Sato S, Razafsky D, Sahu B, Shen SQ, Potter C, Sandell LL, Corbo JC, Palczewski K, Maeda A, Hodzic D, Kefalov VJ. The role of retinol dehydrogenase 10 in the cone visual cycle. Sci Rep. 2017 May 24;7(1):2390. doi: 10.1038/s41598-017-02549-8.PMID: 28539612 Sui X, Weitz AC, Farquhar ER, Badiee M, Banerjee S, von Lintig J, Tochtrop GP, Palczewski K, Hendrich MP, Kiser PD. Structure and Spectroscopy of Alkene-Cleaving Dioxygenases Containing an Atypically Coordinated Non-Heme Iron Center. Biochemistry. 2017 Jun 6;56(22):2836-2852. doi: 10.1021/acs.biochem.7b00251. Epub 2017 May 19.PMID: 28493664 Alexander NS, Katayama K, Sun W, Salom D, Gulati S, Zhang J, Mogi M, Palczewski K, Jastrzebska Complex binding pathways determine the regeneration of mammalian green cone opsin with a locked retinal analogue. J Biol Chem. 2017 Jun 30;292(26):10983-10997. doi: 10.1074/jbc.M117.780478. Epub 2017 May 9.PMID: 28487362 Kiser PD, Zhang J, Badiee M, Kinoshita J, Peachey NS, Tochtrop GP, Palczewski K. Rational Tuning of Visual Cycle Modulator Pharmacodynamics. J Pharmacol Exp Ther. 2017 Jul;362(1):131-145. doi: 10.1124/jpet.117.240721. Epub 2017 May 5.PMID: 28476927 Hofmann L, Alexander NS, Sun W, Zhang J, Orban T, Palczewski K. Hydrogen/Deuterium Exchange Mass Spectrometry of Human Green Opsin Reveals a Conserved Pro-Pro Motif in Extracellular Loop 2 of Monostable Visual G Protein-Coupled Receptors. Biochemistry. 2017 May 2;56(17):2338-2348. doi: 10.1021/acs.biochem.7b00165. Epub 2017 Apr 21.PMID: 28402104 Palczewski K. Skunkworks project for Big Pharma. Pharmacol Res. 2017 Oct;124:167-168. doi: 10.1016/j.phrs.2017.03.022. Epub 2017 Mar 28.PMID: 28363722 No abstract available. Gulati S, Jastrzebska B, Banerjee S, Placeres ÁL, Miszta P, Gao S, Gunderson K, Tochtrop GP, Filipek S, Katayama K, Kiser PD, Mogi M, Stewart PL, Palczewski K. Photocyclic behavior of rhodopsin induced by an atypical isomerization mechanism. Proc Natl Acad Sci U S A. 2017 Mar 28;114(13):E2608-E2615. doi: 10.1073/pnas.1617446114. Epub 2017 Mar 13.PMID: 28289214 Mustafi D, Kevany BM, Bai X, Golczak M, Adams MD, Wynshaw-Boris A, Palczewski K. Transcriptome analysis reveals rod/cone photoreceptor specific signatures across mammalian retinas. Hum Mol Genet. 2016 Oct 15;25(20):4376-4388. doi: 10.1093/hmg/ddw268.PMID: 28172828 Sharma R, Schwarz C, Hunter JJ, Palczewska G, Palczewski K, Williams DR. Formation and Clearance of All-Trans-Retinol in Rods Investigated in the Living Primate Eye With Two-Photon Ophthalmoscopy. Invest Ophthalmol Vis Sci. 2017 Jan 1;58(1):604-613. doi: 10.1167/iovs.16-20061.PMID: 28129424 Sundermeier TR, Sakami S, Sahu B, Howell SJ, Gao S, Dong Z, Golczak M, Maeda A, Palczewski K. MicroRNA-processing Enzymes Are Essential for Survival and Function of Mature Retinal Pigmented Epithelial Cells in Mice. J Biol Chem. 2017 Feb 24;292(8):3366-3378. doi: 10.1074/jbc.M116.770024. Epub 2017 Jan 19.PMID: 28104803 Athanasiou D, Aguila M, Opefi CA, South K, Bellingham J, Bevilacqua D, Munro PM, Kanuga N, Mackenzie FE, Dubis AM, Georgiadis A, Graca AB, Pearson RA, Ali RR, Sakami S, Palczewski K, Sherman MY, Reeves PJ, Cheetham ME. Rescue of mutant rhodopsin traffic by metformin-induced AMPK activation accelerates photoreceptor degeneration. Hum Mol Genet. 2017 Jan 15;26(2):305-319. doi: 10.1093/hmg/ddw387.PMID: 28065882 Jastrzebska B, Comar WD, Kaliszewski MJ, Skinner KC, Torcasio MH, Esway AS, Jin H, Palczewski K, Smith AW. A G Protein-Coupled Receptor Dimerization Interface in Human Cone Opsins. Biochemistry. 2017 Jan 10;56(1):61-72. doi: 10.1021/acs.biochem.6b00877. Epub 2016 Nov 29.PMID: 28045251 Schwarz C, Sharma R, Fischer WS, Chung M, Palczewska G, Palczewski K, Williams DR, Hunter JJ. Safety assessment in macaques of light exposures for functional two-photon ophthalmoscopy in humans. Biomed Opt Express. 2016 Nov 16;7(12):5148-5169. doi: 10.1364/BOE.7.005148. eCollection 2016 Dec 1.PMID: 28018732 Kiser PD, Palczewski K. Retinoids and Retinal Diseases. Annu Rev Vis Sci. 2016 Oct;2:197-234. doi: 10.1146/annurev-vision-111815-114407. Epub 2016 Jul 18.PMID: 27917399 Review. Palczewska G, Maeda A, Golczak M, Arai E, Dong Z, Perusek L, Kevany B, Palczewski K. Receptor MER Tyrosine Kinase Proto-oncogene (MERTK) Is Not Required for Transfer of Bis-retinoids to the Retinal Pigmented Epithelium. J Biol Chem. 2016 Dec 23;291(52):26937-26949. doi: 10.1074/jbc.M116.764563. Epub 2016 Nov 14.PMID: 27875314 Chen Y, Brooks MJ, Gieser L, Swaroop A, Palczewski K. Transcriptome profiling of NIH3T3 cell lines expressing opsin and the P23H opsin mutant identifies candidate drugs for the treatment of retinitis pigmentosa. Pharmacol Res. 2017 Jan;115:1-13. doi: 10.1016/j.phrs.2016.10.031. Epub 2016 Nov 9.PMID: 27838510 Hofmann L, Tsybovsky Y, Alexander NS, Babino D, Leung NY, Montell C, Banerjee S, von Lintig J, Palczewski K. Structural Insights into the Drosophila melanogaster Retinol Dehydrogenase, a Member of the Short-Chain Dehydrogenase/Reductase Family. Biochemistry. 2016 Nov 29;55(47):6545-6557. doi: 10.1021/acs.biochem.6b00907. Epub 2016 Nov 16.PMID: 27809489 Chen Y, Kern TS, Kiser PD, Palczewski K. Eyes on systems pharmacology. Pharmacol Res. 2016 Dec;114:39-41. doi: 10.1016/j.phrs.2016.09.026. Epub 2016 Oct 5.PMID: 27720767 No abstract available. Rajavel M, Orban T, Xu M, Hernandez-Sanchez W, de la Fuente M, Palczewski K, Taylor DJ. Dynamic peptides of human TPP1 fulfill diverse functions in telomere maintenance. Nucleic Acids Res. 2016 Dec 1;44(21):10467-10479. doi: 10.1093/nar/gkw846. Epub 2016 Sep 20.PMID: 27655633 Liu H, Tang J, Du Y, Saadane A, Tonade D, Samuels I, Veenstra A, Palczewski K, Kern TS. Photoreceptor Cells Influence Retinal Vascular Degeneration in Mouse Models of Retinal Degeneration and Diabetes. Invest Ophthalmol Vis Sci. 2016 Aug 1;57(10):4272-81. doi: 10.1167/iovs.16-19415.PMID: 27548901 Chen Y, Palczewska G, Masuho I, Gao S, Jin H, Dong Z, Gieser L, Brooks MJ, Kiser PD, Kern TS, Martemyanov KA, Swaroop A, Palczewski K. Synergistically acting agonists and antagonists of G protein-coupled receptors prevent photoreceptor cell degeneration. Sci Signal. 2016 Jul 26;9(438):ra74. doi: 10.1126/scisignal.aag0245.PMID: 27460988 Yuan S, Chan HC, Vogel H, Filipek S, Stevens RC, Palczewski K. The Molecular Mechanism of P2Y1 Receptor Activation. Angew Chem Int Ed Engl. 2016 Aug 22;55(35):10331-5. doi: 10.1002/anie.201605147. Epub 2016 Jul 27.PMID: 27460867 Sui X, Zhang J, Golczak M, Palczewski K, Kiser PD. Key Residues for Catalytic Function and Metal Coordination in a Carotenoid Cleavage Dioxygenase. J Biol Chem. 2016 Sep 9;291(37):19401-12. doi: 10.1074/jbc.M116.744912. Epub 2016 Jul 24.PMID: 27453555 Alexander NS, Palczewska G, Stremplewski P, Wojtkowski M, Kern TS, Palczewski K. Image registration and averaging of low laser power two-photon fluorescence images of mouse retina. Biomed Opt Express. 2016 Jun 20;7(7):2671-91. doi: 10.1364/BOE.7.002671. eCollection 2016 Jul 1.PMID: 27446697 Yuan S, Peng Q, Palczewski K, Vogel H, Filipek S. Mechanistic Studies on the Stereoselectivity of the Serotonin 5-HT1A Receptor. Angew Chem Int Ed Engl. 2016 Jul 18;55(30):8661-5. doi: 10.1002/anie.201603766. Epub 2016 May 31.PMID: 27244650 Sears AE, Palczewski K. 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Retinol dehydrogenase 8 and ATP-binding cassette transporter 4 modulate dark adaptation of M-cones in mammalian retina. J Physiol. 2015 Nov 15;593(22):4923-41. doi: 10.1113/JP271285. Epub 2015 Oct 18.PMID: 26350353 Jastrzebska B, Chen Y, Orban T, Jin H, Hofmann L, Palczewski K. Disruption of Rhodopsin Dimerization with Synthetic Peptides Targeting an Interaction Interface. J Biol Chem. 2015 Oct 16;290(42):25728-44. doi: 10.1074/jbc.M115.662684. Epub 2015 Sep 1.PMID: 26330551 Alexander NS, Palczewska G, Palczewski K. Semi-automated discrimination of retinal pigmented epithelial cells in two-photon fluorescence images of mouse retinas. Biomed Opt Express. 2015 Jul 23;6(8):3032-52. doi: 10.1364/BOE.6.003032. eCollection 2015 Aug 1.PMID: 26309765 Sun D, Maeno H, Gujrati M, Schur R, Maeda A, Maeda T, Palczewski K, Lu ZR. Self-Assembly of a Multifunctional Lipid With Core-Shell Dendrimer DNA Nanoparticles Enhanced Efficient Gene Delivery at Low Charge Ratios into RPE Cells. 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Endogenous fluorophores enable two-photon imaging of the primate eye. Invest Ophthalmol Vis Sci. 2014 Jun 26;55(7):4438-47. doi: 10.1167/iovs.14-14395.PMID: 24970255 Palczewska G, Dong Z, Golczak M, Hunter JJ, Williams DR, Alexander NS, Palczewski K. Noninvasive two-photon microscopy imaging of mouse retina and retinal pigment epithelium through the pupil of the eye. Nat Med. 2014 Jul;20(7):785-9. doi: 10.1038/nm.3590. Epub 2014 Jun 22.PMID: 24952647 Chen Y, Tang H, Seibel W, Papoian R, Oh K, Li X, Zhang J, Golczak M, Palczewski K, Kiser PD. Identification and characterization of novel inhibitors of Mammalian aspartyl aminopeptidase. Mol Pharmacol. 2014 Aug;86(2):231-42. doi: 10.1124/mol.114.093070. Epub 2014 Jun 9.PMID: 24913940 Amengual J, Zhang N, Kemerer M, Maeda T, Palczewski K, Von Lintig J. STRA6 is critical for cellular vitamin A uptake and homeostasis. Hum Mol Genet. 2014 Oct 15;23(20):5402-17. doi: 10.1093/hmg/ddu258. 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ACS Nano. 2014 Jan 28;8(1):153-61. doi: 10.1021/nn4054107. Epub 2013 Dec 20.PMID: 24350906 Bolze CS, Helbling RE, Owen RL, Pearson AR, Pompidor G, Dworkowski F, Fuchs MR, Furrer J, Golczak M, Palczewski K, Cascella M, Stocker A. Human cellular retinaldehyde-binding protein has secondary thermal 9-cis-retinal isomerase activity. J Am Chem Soc. 2014 Jan 8;136(1):137-46. doi: 10.1021/ja411366w. Epub 2013 Dec 20.PMID: 24328211 2010-2013 Chen Y, Palczewska G, Mustafi D, Golczak M, Dong Z, Sawada O, Maeda T, Maeda A, Palczewski K. Systems pharmacology identifies drug targets for Stargardt disease-associated retinal degeneration. J Clin Invest. 2013 Dec;123(12):5119-34. doi: 10.1172/JCI69076. Epub 2013 Nov 15.PMID: 24231350 Sakami S, Kolesnikov AV, Kefalov VJ, Palczewski K. P23H opsin knock-in mice reveal a novel step in retinal rod disc morphogenesis. Hum Mol Genet. 2014 Apr 1;23(7):1723-41. doi: 10.1093/hmg/ddt561. 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From atomic structures to neuronal functions of g protein-coupled receptors. Annu Rev Neurosci. 2013 Jul 8;36:139-64. doi: 10.1146/annurev-neuro-062012-170313. Epub 2013 May 15.PMID: 23682660 Review. Palczewski K, Kiser PD. Biochemistry. As good as chocolate. Science. 2013 May 3;340(6132):562-3. doi: 10.1126/science.1238521.PMID: 23641106 No abstract available. Kohno H, Chen Y, Kevany BM, Pearlman E, Miyagi M, Maeda T, Palczewski K, Maeda A. Photoreceptor proteins initiate microglial activation via Toll-like receptor 4 in retinal degeneration mediated by all-trans-retinal. J Biol Chem. 2013 May 24;288(21):15326-41. doi: 10.1074/jbc.M112.448712. Epub 2013 Apr 9.PMID: 23572532 Mustafi D, Kevany BM, Bai X, Maeda T, Sears JE, Khalil AM, Palczewski K. Evolutionarily conserved long intergenic non-coding RNAs in the eye. Hum Mol Genet. 2013 Aug 1;22(15):2992-3002. doi: 10.1093/hmg/ddt156. Epub 2013 Apr 4.PMID: 23562822 Tsybovsky Y, Orban T, Molday RS, Taylor D, Palczewski K. Molecular organization and ATP-induced conformational changes of ABCA4, the photoreceptor-specific ABC transporter. Structure. 2013 May 7;21(5):854-60. doi: 10.1016/j.str.2013.03.001. Epub 2013 Apr 4.PMID: 23562398 Tian M, Zallocchi M, Wang W, Chen CK, Palczewski K, Delimont D, Cosgrove D, Peng YW. Light-induced translocation of RGS9-1 and Gβ5L in mouse rod photoreceptors. PLoS One. 2013;8(3):e58832. doi: 10.1371/journal.pone.0058832. Epub 2013 Mar 28.PMID: 23555598 Jastrzebska B, Ringler P, Palczewski K, Engel A. The rhodopsin-transducin complex houses two distinct rhodopsin molecules. J Struct Biol. 2013 May;182(2):164-72. doi: 10.1016/j.jsb.2013.02.014. Epub 2013 Feb 28.PMID: 23458690 Yan J, Kaur S, DeLucia M, Hao C, Mehrens J, Wang C, Golczak M, Palczewski K, Gronenborn AM, Ahn J, Skowronski J. Tetramerization of SAMHD1 is required for biological activity and inhibition of HIV infection. J Biol Chem. 2013 Apr 12;288(15):10406-17. doi: 10.1074/jbc.M112.443796. Epub 2013 Feb 20.PMID: 23426366 Padayatti PS, Wang L, Gupta S, Orban T, Sun W, Salom D, Jordan SR, Palczewski K, Chance MR. A hybrid structural approach to analyze ligand binding by the serotonin type 4 receptor (5-HT4). Mol Cell Proteomics. 2013 May;12(5):1259-71. doi: 10.1074/mcp.M112.025536. Epub 2013 Feb 1.PMID: 23378516 Jastrzebska B, Salom D, Jin H, Cao P, Sun W, Palczewski K, Feng Z. Expression of mammalian G protein-coupled receptors in Caenorhabditis elegans. Methods Enzymol. 2013;520:239-56. doi: 10.1016/B978-0-12-391861-1.00011-3.PMID: 23332703 Jastrzebska B, Orban T, Golczak M, Engel A, Palczewski K. Asymmetry of the rhodopsin dimer in complex with transducin. FASEB J. 2013 Apr;27(4):1572-84. doi: 10.1096/fj.12-225383. Epub 2013 Jan 9.PMID: 23303210 Maeda A, Palczewski K. Retinal degeneration in animal models with a defective visual cycle. Drug Discov Today Dis Models. 2013 Winter;10(4):e163-e172. doi: 10.1016/j.ddmod.2014.01.001.PMID: 25210527 Vahedi-Faridi A, Jastrzebska B, Palczewski K, Engel A. 3D imaging and quantitative analysis of small solubilized membrane proteins and their complexes by transmission electron microscopy. Microscopy (Oxf). 2013 Feb;62(1):95-107. doi: 10.1093/jmicro/dfs091. Epub 2012 Dec 23.PMID: 23267047 Latek D, Modzelewska A, Trzaskowski B, Palczewski K, Filipek S. G protein-coupled receptors--recent advances. Acta Biochim Pol. 2012;59(4):515-29. Epub 2012 Dec 18.PMID: 23251911 Review. Maeda T, Dong Z, Jin H, Sawada O, Gao S, Utkhede D, Monk W, Palczewska G, Palczewski K. QLT091001, a 9-cis-retinal analog, is well-tolerated by retinas of mice with impaired visual cycles. Invest Ophthalmol Vis Sci. 2013 Jan 17;54(1):455-66. doi: 10.1167/iovs.12-11152.PMID: 23249702 Zhang N, Kolesnikov AV, Jastrzebska B, Mustafi D, Sawada O, Maeda T, Genoud C, Engel A, Kefalov VJ, Palczewski K. Autosomal recessive retinitis pigmentosa E150K opsin mice exhibit photoreceptor disorganization. J Clin Invest. 2013 Jan;123(1):121-37. doi: 10.1172/JCI66176. Epub 2012 Dec 10.PMID: 23221340 Kiser PD, Farquhar ER, Shi W, Sui X, Chance MR, Palczewski K. Structure of RPE65 isomerase in a lipidic matrix reveals roles for phospholipids and iron in catalysis. Proc Natl Acad Sci U S A. 2012 Oct 9;109(41):E2747-56. doi: 10.1073/pnas.1212025109. Epub 2012 Sep 24.PMID: 23012475 Gao SQ, Maeda T, Okano K, Palczewski K. A microparticle/hydrogel combination drug-delivery system for sustained release of retinoids. Invest Ophthalmol Vis Sci. 2012 Sep 19;53(10):6314-23. doi: 10.1167/iovs.12-10279.PMID: 22918645 Tu X, Palczewski K. Crystal structure of the globular domain of C1QTNF5: Implications for late-onset retinal macular degeneration. J Struct Biol. 2012 Dec;180(3):439-46. doi: 10.1016/j.jsb.2012.07.011. Epub 2012 Aug 7.PMID: 22892318 Mustafi D, Maeda T, Kohno H, Nadeau JH, Palczewski K. Inflammatory priming predisposes mice to age-related retinal degeneration. J Clin Invest. 2012 Aug;122(8):2989-3001. doi: 10.1172/JCI64427. Epub 2012 Jul 17.PMID: 22797304 Hachiya A, Marchand B, Kirby KA, Michailidis E, Tu X, Palczewski K, Ong YT, Li Z, Griffin DT, Schuckmann MM, Tanuma J, Oka S, Singh K, Kodama EN, Sarafianos SG. HIV-1 reverse transcriptase (RT) polymorphism 172K suppresses the effect of clinically relevant drug resistance mutations to both nucleoside and non-nucleoside RT inhibitors. J Biol Chem. 2012 Aug 24;287(35):29988-99. doi: 10.1074/jbc.M112.351551. Epub 2012 Jul 2.PMID: 22761416 Amengual J, Golczak M, Palczewski K, von Lintig J.Lecithin:retinol acyltransferase is critical for cellular uptake of vitamin A from serum retinol-binding protein. J Biol Chem. 2012 Jul 13;287(29):24216-27. doi: 10.1074/jbc.M112.353979. Epub 2012 May 27.PMID: 22637576 Golczak M, Kiser PD, Sears AE, Lodowski DT, Blaner WS, Palczewski K. Structural basis for the acyltransferase activity of lecithin:retinol acyltransferase-like proteins. J Biol Chem. 2012 Jul 6;287(28):23790-807. doi: 10.1074/jbc.M112.361550. Epub 2012 May 17.PMID: 22605381 Orban T, Jastrzebska B, Gupta S, Wang B, Miyagi M, Chance MR, Palczewski K. Conformational dynamics of activation for the pentameric complex of dimeric G protein-coupled receptor and heterotrimeric G protein. Structure. 2012 May 9;20(5):826-40. doi: 10.1016/j.str.2012.03.017.PMID: 22579250 Sexton TJ, Golczak M, Palczewski K, Van Gelder RN. Melanopsin is highly resistant to light and chemical bleaching in vivo. J Biol Chem. 2012 Jun 15;287(25):20888-97. doi: 10.1074/jbc.M111.325969. Epub 2012 Apr 30.PMID: 22547062 Orban T, Huang CC, Homan KT, Jastrzebska B, Tesmer JJ, Palczewski K. Substrate-induced changes in the dynamics of rhodopsin kinase (G protein-coupled receptor kinase 1).Biochemistry. 2012 Apr 24;51(16):3404-11. doi: 10.1021/bi300295y. Epub 2012 Apr 11.PMID: 22480180 Sundermeier TR, Palczewski K. The physiological impact of microRNA gene regulation in the retina. Cell Mol Life Sci. 2012 Aug;69(16):2739-50. doi: 10.1007/s00018-012-0976-7. Epub 2012 Mar 30.PMID: 22460583 Review. Chen Y, Farquhar ER, Chance MR, Palczewski K, Kiser PD. Insights into substrate specificity and metal activation of mammalian tetrahedral aspartyl aminopeptidase. J Biol Chem. 2012 Apr 13;287(16):13356-70. doi: 10.1074/jbc.M112.347518. Epub 2012 Feb 22.PMID: 22356908 Padayatti P, Palczewska G, Sun W, Palczewski K, Salom D. Imaging of protein crystals with two-photon microscopy. Biochemistry. 2012 Feb 28;51(8):1625-37. doi: 10.1021/bi201682q. Epub 2012 Feb 16.PMID: 22324807 Okano K, Maeda A, Chen Y, Chauhan V, Tang J, Palczewska G, Sakai T, Tsuneoka H, Palczewski K, Maeda T. Retinal cone and rod photoreceptor cells exhibit differential susceptibility to light-induced damage. J Neurochem. 2012 Apr;121(1):146-56. doi: 10.1111/j.1471-4159.2012.07647.x. Epub 2012 Feb 9.PMID: 22220722 Maeda A, Golczak M, Chen Y, Okano K, Kohno H, Shiose S, Ishikawa K, Harte W, Palczewska G, Maeda T, Palczewski K. Primary amines protect against retinal degeneration in mouse models of retinopathies. Nat Chem Biol. 2011 Dec 25;8(2):170-8. doi: 10.1038/nchembio.759.PMID: 22198730 Chen Y, Okano K, Maeda T, Chauhan V, Golczak M, Maeda A, Palczewski K. Mechanism of all-trans-retinal toxicity with implications for stargardt disease and age-related macular degeneration. J Biol Chem. 2012 Feb 10;287(7):5059-69. doi: 10.1074/jbc.M111.315432. Epub 2011 Dec 19.PMID: 22184108 Salom D, Wang B, Dong Z, Sun W, Padayatti P, Jordan S, Salon JA, Palczewski K. Post-translational modifications of the serotonin type 4 receptor heterologously expressed in mouse rod cells. Biochemistry. 2012 Jan 10;51(1):214-24. doi: 10.1021/bi201707v. Epub 2011 Dec 20.PMID: 22145929 Salom D, Cao P, Sun W, Kramp K, Jastrzebska B, Jin H, Feng Z, Palczewski K. Heterologous expression of functional G-protein-coupled receptors in Caenorhabditis elegans. FASEB J. 2012 Feb;26(2):492-502. doi: 10.1096/fj.11-197780. Epub 2011 Nov 16.PMID: 22090314 Cao P, Sun W, Kramp K, Zheng M, Salom D, Jastrzebska B, Jin H, Palczewski K, Feng Z. Light-sensitive coupling of rhodopsin and melanopsin to G(i/o) and G(q) signal transduction in Caenorhabditis elegans. FASEB J. 2012 Feb;26(2):480-91. doi: 10.1096/fj.11-197798. Epub 2011 Nov 16.PMID: 22090313 Palczewski K. J Chemistry and biology of vision. Biol Chem. 2012 Jan 13;287(3):1612-9. doi: 10.1074/jbc.R111.301150. Epub 2011 Nov 10.PMID: 22074921 Review. Palczewski K. Thematic minireview series on focus on vision. J Biol Chem. 2012 Jan 13;287(3):1610-1. doi: 10.1074/jbc.R111.322347. Epub 2011 Nov 10.PMID: 22074916 No abstract available. Baker BY, Palczewski K. Detergents stabilize the conformation of phosphodiesterase 6. Biochemistry. 2011 Nov 8;50(44):9520-31. doi: 10.1021/bi2014695. Epub 2011 Oct 14.PMID: 21978030 Salon JA, Lodowski DT, Palczewski K. The significance of G protein-coupled receptor crystallography for drug discovery. Pharmacol Rev. 2011 Dec;63(4):901-37. doi: 10.1124/pr.110.003350.PMID: 21969326 Review. Jastrzebska B, Ringler P, Lodowski DT, Moiseenkova-Bell V, Golczak M, Müller SA, Palczewski K, Engel A.Rhodopsin-transducin heteropentamer: three-dimensional structure and biochemical characterization. J Struct Biol. 2011 Dec;176(3):387-94. doi: 10.1016/j.jsb.2011.08.016. Epub 2011 Sep 6.PMID: 21925606 Maeda T, Perusek L, Amengual J, Babino D, Palczewski K, von Lintig J. Dietary 9-cis-β,β-carotene fails to rescue vision in mouse models of leber congenital amaurosis. Mol Pharmacol. 2011 Nov;80(5):943-52. doi: 10.1124/mol.111.074732. Epub 2011 Aug 23.PMID: 21862692 Zhu Q, Sun W, Okano K, Chen Y, Zhang N, Maeda T, Palczewski K. Sponge transgenic mouse model reveals important roles for the microRNA-183 (miR-183)/96/182 cluster in postmitotic photoreceptors of the retina. J Biol Chem. 2011 Sep 9;286(36):31749-60. doi: 10.1074/jbc.M111.259028. Epub 2011 Jul 15.PMID: 21768104 Tsybovsky Y, Wang B, Quazi F, Molday RS, Palczewski K. Posttranslational modifications of the photoreceptor-specific ABC transporter ABCA4. Biochemistry. 2011 Aug 16;50(32):6855-66. doi: 10.1021/bi200774w. Epub 2011 Jul 8.PMID: 21721517 Mustafi D, Kevany BM, Genoud C, Okano K, Cideciyan AV, Sumaroka A, Roman AJ, Jacobson SG, Engel A, Adams MD, Palczewski K. Defective photoreceptor phagocytosis in a mouse model of enhanced S-cone syndrome causes progressive retinal degeneration. FASEB J. 2011 Sep;25(9):3157-76. doi: 10.1096/fj.11-186767. Epub 2011 Jun 9.PMID: 21659555 Peshenko IV, Olshevskaya EV, Savchenko AB, Karan S, Palczewski K, Baehr W, Dizhoor AM. Enzymatic properties and regulation of the native isozymes of retinal membrane guanylyl cyclase (RetGC) from mouse photoreceptors. Biochemistry. 2011 Jun 28;50(25):5590-600. doi: 10.1021/bi200491b. Epub 2011 Jun 6.PMID: 21598940 Jastrzebska B, Palczewski K, Golczak M. Role of bulk water in hydrolysis of the rhodopsin chromophore. J Biol Chem. 2011 May 27;286(21):18930-7. doi: 10.1074/jbc.M111.234583. Epub 2011 Apr 1.PMID: 21460218 Orban T, Palczewska G, Palczewski K. Retinyl ester storage particles (retinosomes) from the retinal pigmented epithelium resemble lipid droplets in other tissues. J Biol Chem. 2011 May 13;286(19):17248-58. doi: 10.1074/jbc.M110.195198. Epub 2011 Mar 25.PMID: 21454509 Bereta G, Palczewski K. Heterogeneous N-terminal acylation of retinal proteins results from the retina's unusual lipid metabolism. Biochemistry. 2011 May 10;50(18):3764-76. doi: 10.1021/bi200245t. Epub 2011 Apr 11.PMID: 21449552 Kiser PD, Golczak M, Maeda A, Palczewski K. Key enzymes of the retinoid (visual) cycle in vertebrate retina. Biochim Biophys Acta. 2012 Jan;1821(1):137-51. doi: 10.1016/j.bbalip.2011.03.005. Epub 2011 Apr 5.PMID: 21447403 Review. Mustafi D, Avishai A, Avishai N, Engel A, Heuer A, Palczewski K. Serial sectioning for examination of photoreceptor cell architecture by focused ion beam technology. J Neurosci Methods. 2011 May 15;198(1):70-6. doi: 10.1016/j.jneumeth.2011.03.013. Epub 2011 Mar 23.PMID: 21439323 Jastrzebska B, Debinski A, Filipek S, Palczewski K.Role of membrane integrity on G protein-coupled receptors: Rhodopsin stability and function. Prog Lipid Res. 2011 Jul;50(3):267-77. doi: 10.1016/j.plipres.2011.03.002. Epub 2011 Mar 22.PMID: 21435354 Review. Shiose S, Chen Y, Okano K, Roy S, Kohno H, Tang J, Pearlman E, Maeda T, Palczewski K, Maeda A. Toll-like receptor 3 is required for development of retinopathy caused by impaired all-trans-retinal clearance in mice. J Biol Chem. 2011 Apr 29;286(17):15543-55. doi: 10.1074/jbc.M111.228551. Epub 2011 Mar 7.PMID: 21383019 Hunter JJ, Masella B, Dubra A, Sharma R, Yin L, Merigan WH, Palczewska G, Palczewski K, Williams DR. Images of photoreceptors in living primate eyes using adaptive optics two-photon ophthalmoscopy. Biomed Opt Express. 2010 Dec 17;2(1):139-48. doi: 10.1364/BOE.2.000139.PMID: 21326644 Palczewski K. Focus on vision: 3 decades of remarkable contributions to biology and medicine. FASEB J. 2011 Feb;25(2):439-43. doi: 10.1096/fj.11-0202ufm.PMID: 21282210 Huang CC, Orban T, Jastrzebska B, Palczewski K, Tesmer JJ. Activation of G protein-coupled receptor kinase 1 involves interactions between its N-terminal region and its kinase domain. Biochemistry. 2011 Mar 22;50(11):1940-9. doi: 10.1021/bi101606e. Epub 2011 Feb 22.PMID: 21265573 Sakami S, Maeda T, Bereta G, Okano K, Golczak M, Sumaroka A, Roman AJ, Cideciyan AV, Jacobson SG, Palczewski K. Probing mechanisms of photoreceptor degeneration in a new mouse model of the common form of autosomal dominant retinitis pigmentosa due to P23H opsin mutations. J Biol Chem. 2011 Mar 25;286(12):10551-67. doi: 10.1074/jbc.M110.209759. Epub 2011 Jan 11.PMID: 21224384 Mast N, Annalora AJ, Lodowski DT, Palczewski K, Stout CD, Pikuleva IA. J Structural basis for three-step sequential catalysis by the cholesterol side chain cleavage enzyme CYP11A1. Biol Chem. 2011 Feb 18;286(7):5607-13. doi: 10.1074/jbc.M110.188433. Epub 2010 Dec 15.PMID: 21159775 Amengual J, Lobo GP, Golczak M, Li HN, Klimova T, Hoppel CL, Wyss A, Palczewski K, von Lintig J. A mitochondrial enzyme degrades carotenoids and protects against oxidative stress. FASEB J. 2011 Mar;25(3):948-59. doi: 10.1096/fj.10-173906. Epub 2010 Nov 24.PMID: 21106934 Palczewska G, Maeda T, Imanishi Y, Sun W, Chen Y, Williams DR, Piston DW, Maeda A, Palczewski K. Noninvasive multiphoton fluorescence microscopy resolves retinol and retinal condensation products in mouse eyes. Nat Med. 2010 Dec;16(12):1444-9. doi: 10.1038/nm.2260. Epub 2010 Nov 14.PMID: 21076393 Palczewski K. Blind dogs that can see: pharmacological treatment of Leber congenital amaurosis caused by a defective visual cycle. Arch Ophthalmol. 2010 Nov;128(11):1483-5. doi: 10.1001/archophthalmol.2010.245.PMID: 21060052 No abstract available. Lodowski DT, Palczewski K, Miyagi M. Conformational changes in the g protein-coupled receptor rhodopsin revealed by histidine hydrogen-deuterium exchange. Biochemistry. 2010 Nov 9;49(44):9425-7. doi: 10.1021/bi101502v. Epub 2010 Oct 15.PMID: 20939497 Li H, Palczewski K, Baehr W, Clagett-Dame M. Vitamin A deficiency results in meiotic failure and accumulation of undifferentiated spermatogonia in prepubertal mouse testis. Biol Reprod. 2011 Feb;84(2):336-41. doi: 10.1095/biolreprod.110.086157. Epub 2010 Sep 29.PMID: 20881313 Huang J, Xu Z, Wang D, Ogata CM, Palczewski K, Lee X, Young NM. Characterization of the secondary binding sites of Maclura pomifera agglutinin by glycan array and crystallographic analyses. Glycobiology. 2010 Dec;20(12):1643-53. doi: 10.1093/glycob/cwq118. Epub 2010 Sep 8.PMID: 20826825 Tsybovsky Y, Molday RS, Palczewski K. The ATP-binding cassette transporter ABCA4: structural and functional properties and role in retinal disease. Adv Exp Med Biol. 2010;703:105-25. doi: 10.1007/978-1-4419-5635-4_8.PMID: 20711710 Review. Golczak M, Palczewski K. An acyl-covalent enzyme intermediate of lecithin:retinol acyltransferase. J Biol Chem. 2010 Sep 17;285(38):29217-22. doi: 10.1074/jbc.M110.152314. Epub 2010 Jul 12.PMID: 20628054 Pulagam LP, Palczewski K. Electrostatic compensation restores trafficking of the autosomal recessive retinitis pigmentosa E150K opsin mutant to the plasma membrane. J Biol Chem. 2010 Sep 17;285(38):29446-56. doi: 10.1074/jbc.M110.151407. Epub 2010 Jul 13.PMID: 20628051 Goc A, Chami M, Lodowski DT, Bosshart P, Moiseenkova-Bell V, Baehr W, Engel A, Palczewski K. Structural characterization of the rod cGMP phosphodiesterase 6. J Mol Biol. 2010 Aug 20;401(3):363-73. doi: 10.1016/j.jmb.2010.06.044. Epub 2010 Jul 1.PMID: 20600113 Lobo GP, Amengual J, Li HN, Golczak M, Bonet ML, Palczewski K, von Lintig J. Beta,beta-carotene decreases peroxisome proliferator receptor gamma activity and reduces lipid storage capacity of adipocytes in a beta,beta-carotene oxygenase 1-dependent manner. J Biol Chem. 2010 Sep 3;285(36):27891-9. doi: 10.1074/jbc.M110.132571. Epub 2010 Jun 23.PMID: 20573961 Imanishi Y, Palczewski K. Visualization of retinoid storage and trafficking by two-photon microscopy. Methods Mol Biol. 2010;652:247-61. doi: 10.1007/978-1-60327-325-1_14.PMID: 20552433 Golczak M, Bereta G, Maeda A, Palczewski K. Molecular biology and analytical chemistry methods used to probe the retinoid cycle. Methods Mol Biol. 2010;652:229-45. doi: 10.1007/978-1-60327-325-1_13.PMID: 20552432 Palczewski K. Oligomeric forms of G protein-coupled receptors (GPCRs). Trends Biochem Sci. 2010 Nov;35(11):595-600. doi: 10.1016/j.tibs.2010.05.002. Epub 2010 Jun 9.PMID: 20538466 Khelashvili G, Dorff K, Shan J, Camacho-Artacho M, Skrabanek L, Vroling B, Bouvier M, Devi LA, George SR, Javitch JA, Lohse MJ, Milligan G, Neubig RR, Palczewski K, Parmentier M, Pin JP, Vriend G, Campagne F, Filizola M. GPCR-OKB: the G Protein Coupled Receptor Oligomer Knowledge Base. Bioinformatics. 2010 Jul 15;26(14):1804-5. doi: 10.1093/bioinformatics/btq264. Epub 2010 May 25.PMID: 20501551 Palczewski K. Retinoids for treatment of retinal diseases. Trends Pharmacol Sci. 2010 Jun;31(6):284-95. doi: 10.1016/j.tips.2010.03.001.PMID: 20435355 Review. Jastrzebska B, Tsybovsky Y, Palczewski K. Complexes between photoactivated rhodopsin and transducin: progress and questions. Biochem J. 2010 Apr 28;428(1):1-10. doi: 10.1042/BJ20100270.PMID: 20423327 Review. Maeda A, Okano K, Park PS, Lem J, Crouch RK, Maeda T, Palczewski K. Palmitoylation stabilizes unliganded rod opsin. Proc Natl Acad Sci U S A. 2010 May 4;107(18):8428-33. doi: 10.1073/pnas.1000640107. Epub 2010 Apr 19.PMID: 20404157 Kiser PD, Palczewski K. Membrane-binding and enzymatic properties of RPE65. Prog Retin Eye Res. 2010 Sep;29(5):428-42. doi: 10.1016/j.preteyeres.2010.03.002. Epub 2010 Mar 19.PMID: 20304090 Review. von Lintig J, Kiser PD, Golczak M, Palczewski K. The biochemical and structural basis for trans-to-cis isomerization of retinoids in the chemistry of vision. Trends Biochem Sci. 2010 Jul;35(7):400-10. doi: 10.1016/j.tibs.2010.01.005. Epub 2010 Feb 24.PMID: 20188572 Review. Cao P, Yuan Y, Pehek EA, Moise AR, Huang Y, Palczewski K, Feng Z. Alpha-synuclein disrupted dopamine homeostasis leads to dopaminergic neuron degeneration in Caenorhabditis elegans. PLoS One. 2010 Feb 19;5(2):e9312. doi: 10.1371/journal.pone.0009312.PMID: 20174477 Orban T, Bereta G, Miyagi M, Wang B, Chance MR, Sousa MC, Palczewski K. Conformational changes in guanylate cyclase-activating protein 1 induced by Ca2+ and N-terminal fatty acid acylation. Structure. 2010 Jan 13;18(1):116-26. doi: 10.1016/j.str.2009.11.008.PMID: 20152158 Kevany BM, Palczewski K. Phagocytosis of retinal rod and cone photoreceptors. Physiology (Bethesda). 2010 Feb;25(1):8-15. doi: 10.1152/physiol.00038.2009.PMID: 20134024 Review. Golczak M, Kiser PD, Lodowski DT, Maeda A, Palczewski K. Importance of membrane structural integrity for RPE65 retinoid isomerization activity. J Biol Chem. 2010 Mar 26;285(13):9667-9682. doi: 10.1074/jbc.M109.063941. Epub 2010 Jan 25.PMID: 20100834 Lobo GP, Hessel S, Eichinger A, Noy N, Moise AR, Wyss A, Palczewski K, von Lintig J. ISX is a retinoic acid-sensitive gatekeeper that controls intestinal beta,beta-carotene absorption and vitamin A production. FASEB J. 2010 Jun;24(6):1656-66. doi: 10.1096/fj.09-150995. Epub 2010 Jan 8.PMID: 20061533 Orban T, Gupta S, Palczewski K, Chance MR. Visualizing water molecules in transmembrane proteins using radiolytic labeling methods. Biochemistry. 2010 Feb 9;49(5):827-34. doi: 10.1021/bi901889t.PMID: 20047303 Review. O'Byrne SM, Kako Y, Deckelbaum RJ, Hansen IH, Palczewski K, Goldberg IJ, Blaner WS. Multiple pathways ensure retinoid delivery to milk: studies in genetically modified mice. Am J Physiol Endocrinol Metab. 2010 Apr;298(4):E862-70. doi: 10.1152/ajpendo.00491.2009. Epub 2009 Dec 29.PMID: 20040693 Moise AR, Lobo GP, Erokwu B, Wilson DL, Peck D, Alvarez S, Domínguez M, Alvarez R, Flask CA, de Lera AR, von Lintig J, Palczewski K. Increased adiposity in the retinol saturase-knockout mouse. FASEB J. 2010 Apr;24(4):1261-70. doi: 10.1096/fj.09-147207. 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Hum Mol Genet. 2009 Aug 1;18(15):2748-60. doi: 10.1093/hmg/ddp210. Epub 2009 May 3.PMID: 19414487 Jastrzebska B, Goc A, Golczak M, Palczewski K. Phospholipids are needed for the proper formation, stability, and function of the photoactivated rhodopsin-transducin complex. Biochemistry. 2009 Jun 16;48(23):5159-70. doi: 10.1021/bi900284x.PMID: 19413332 Maeda T, Maeda A, Casadesus G, Palczewski K, Margaron P. Evaluation of 9-cis-retinyl acetate therapy in Rpe65-/- mice. Invest Ophthalmol Vis Sci. 2009 Sep;50(9):4368-78. doi: 10.1167/iovs.09-3700. Epub 2009 Apr 30.PMID: 19407008 Park PS, Sapra KT, Jastrzebska B, Maeda T, Maeda A, Pulawski W, Kono M, Lem J, Crouch RK, Filipek S, Müller DJ, Palczewski K. Modulation of molecular interactions and function by rhodopsin palmitylation. Biochemistry. 2009 May 26;48(20):4294-304. doi: 10.1021/bi900417b.PMID: 19348429 Lodowski DT, Palczewski K. Chemokine receptors and other G protein-coupled receptors. Curr Opin HIV AIDS. 2009 Mar;4(2):88-95. doi: 10.1097/COH.0b013e3283223d8d.PMID: 19339946 Review. Maeda T, Cideciyan AV, Maeda A, Golczak M, Aleman TS, Jacobson SG, Palczewski K. Loss of cone photoreceptors caused by chromophore depletion is partially prevented by the artificial chromophore pro-drug, 9-cis-retinyl acetate. Hum Mol Genet. 2009 Jun 15;18(12):2277-87. doi: 10.1093/hmg/ddp163. Epub 2009 Apr 1.PMID: 19339306 Maeda A, Maeda T, Golczak M, Chou S, Desai A, Hoppel CL, Matsuyama S, Palczewski K. Involvement of all-trans-retinal in acute light-induced retinopathy of mice. J Biol Chem. 2009 May 29;284(22):15173-83. doi: 10.1074/jbc.M900322200. Epub 2009 Mar 20.PMID: 19304658 Lodowski DT, Angel TE, Palczewski K. Comparative analysis of GPCR crystal structures. Photochem Photobiol. 2009 Mar-Apr;85(2):425-30. doi: 10.1111/j.1751-1097.2008.00516.x. Epub 2009 Jan 19.PMID: 19192200 Review. Baehr W, Palczewski K. Focus on molecules: guanylate cyclase-activating proteins (GCAPs). 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Biochemistry. 2008 Sep 16;47(37):9856-65. doi: 10.1021/bi800905v. Epub 2008 Aug 23.PMID: 18722466 Maeda T, Maeda A, Leahy P, Saperstein DA, Palczewski K. Effects of long-term administration of 9-cis-retinyl acetate on visual function in mice. Invest Ophthalmol Vis Sci. 2009 Jan;50(1):322-33. doi: 10.1167/iovs.08-2301. Epub 2008 Aug 15.PMID: 18708622 Jiang L, Wheaton D, Bereta G, Zhang K, Palczewski K, Birch DG, Baehr W. A novel GCAP1(N104K) mutation in EF-hand 3 (EF3) linked to autosomal dominant cone dystrophy. Vision Res. 2008 Oct;48(23-24):2425-32. doi: 10.1016/j.visres.2008.07.016. Epub 2008 Sep 16.PMID: 18706439 Maeda A, Maeda T, Golczak M, Palczewski K. Retinopathy in mice induced by disrupted all-trans-retinal clearance. J Biol Chem. 2008 Sep 26;283(39):26684-93. doi: 10.1074/jbc.M804505200. Epub 2008 Jul 25.PMID: 18658157 Imanishi Y, Sun W, Maeda T, Maeda A, Palczewski K. Retinyl ester homeostasis in the adipose differentiation-related protein-deficient retina. J Biol Chem. 2008 Sep 5;283(36):25091-102. doi: 10.1074/jbc.M802981200. Epub 2008 Jul 7.PMID: 18606814 Zhang H, Fan J, Li S, Karan S, Rohrer B, Palczewski K, Frederick JM, Crouch RK, Baehr W. Trafficking of membrane-associated proteins to cone photoreceptor outer segments requires the chromophore 11-cis-retinal. J Neurosci. 2008 Apr 9;28(15):4008-14. doi: 10.1523/JNEUROSCI.0317-08.2008.PMID: 18400900 Wongsiriroj N, Piantedosi R, Palczewski K, Goldberg IJ, Johnston TP, Li E, Blaner WS. The molecular basis of retinoid absorption: a genetic dissection. J Biol Chem. 2008 May 16;283(20):13510-9. doi: 10.1074/jbc.M800777200. Epub 2008 Mar 17.PMID: 18348983 Stephen R, Filipek S, Palczewski K, Sousa MC. Ca2+ -dependent regulation of phototransduction. Photochem Photobiol. 2008 Jul-Aug;84(4):903-10. doi: 10.1111/j.1751-1097.2008.00323.x. Epub 2008 Mar 12.PMID: 18346093 Review. Singh P, Wang B, Maeda T, Palczewski K, Tesmer JJ. 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Structure. 2007 Nov;15(11):1392-402. doi: 10.1016/j.str.2007.09.013.PMID: 17997965 Schonthaler HB, Lampert JM, Isken A, Rinner O, Mader A, Gesemann M, Oberhauser V, Golczak M, Biehlmaier O, Palczewski K, Neuhauss SC, von Lintig J. Evidence for RPE65-independent vision in the cone-dominated zebrafish retina. Eur J Neurosci. 2007 Oct;26(7):1940-9. doi: 10.1111/j.1460-9568.2007.05801.x. Epub 2007 Sep 14.PMID: 17868371 Jacobson SG, Aleman TS, Cideciyan AV, Heon E, Golczak M, Beltran WA, Sumaroka A, Schwartz SB, Roman AJ, Windsor EA, Wilson JM, Aguirre GD, Stone EM, Palczewski K.Human cone photoreceptor dependence on RPE65 isomerase. Proc Natl Acad Sci U S A. 2007 Sep 18;104(38):15123-8. doi: 10.1073/pnas.0706367104. Epub 2007 Sep 11.PMID: 17848510 Park PS, Lodowski DT, Palczewski K. Activation of G protein-coupled receptors: beyond two-state models and tertiary conformational changes. 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Proc Natl Acad Sci U S A. 2005 Apr 26;102(17):6177-82. doi: 10.1073/pnas.0500646102. Epub 2005 Apr 18.PMID: 15837919 Moise AR, von Lintig J, Palczewski K. Related enzymes solve evolutionarily recurrent problems in the metabolism of carotenoids. Trends Plant Sci. 2005 Apr;10(4):178-86. doi: 10.1016/j.tplants.2005.02.006.PMID: 15817419 Review. Sokal I, Dupps WJ, Grassi MA, Brown J Jr, Affatigato LM, Roychowdhury N, Yang L, Filipek S, Palczewski K, Stone EM, Baehr W. A novel GCAP1 missense mutation (L151F) in a large family with autosomal dominant cone-rod dystrophy (adCORD). Invest Ophthalmol Vis Sci. 2005 Apr;46(4):1124-32. doi: 10.1167/iovs.04-1431.PMID: 15790869 Suda K, Filipek S, Palczewski K, Engel A, Fotiadis D. The supramolecular structure of the GPCR rhodopsin in solution and native disc membranes. 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Diversity of guanylate cyclase-activating proteins (GCAPs) in teleost fish: characterization of three novel GCAPs (GCAP4, GCAP5, GCAP7) from zebrafish (Danio rerio) and prediction of eight GCAPs (GCAP1-8) in pufferfish (Fugu rubripes). J Mol Evol. 2004 Aug;59(2):204-217. doi: 10.1007/s00239-004-2614-y.PMID: 15486694 Tu DC, Batten ML, Palczewski K, Van Gelder RN. Nonvisual photoreception in the chick iris. Science. 2004 Oct 1;306(5693):129-31. doi: 10.1126/science.1101484.PMID: 15459395 Zhu L, Jang GF, Jastrzebska B, Filipek S, Pearce-Kelling SE, Aguirre GD, Stenkamp RE, Acland GM, Palczewski K. A naturally occurring mutation of the opsin gene (T4R) in dogs affects glycosylation and stability of the G protein-coupled receptor. J Biol Chem. 2004 Dec 17;279(51):53828-39. doi: 10.1074/jbc.M408472200. Epub 2004 Sep 30.PMID: 15459196 Haeseleer F, Imanishi Y, Maeda T, Possin DE, Maeda A, Lee A, Rieke F, Palczewski K. Essential role of Ca2+-binding protein 4, a Cav1.4 channel regulator, in photoreceptor synaptic function. Nat Neurosci. 2004 Oct;7(10):1079-87. doi: 10.1038/nn1320. Epub 2004 Sep 26.PMID: 15452577 Subramanian L, Crabb JW, Cox J, Durussel I, Walker TM, van Ginkel PR, Bhattacharya S, Dellaria JM, Palczewski K, Polans AS. Ca2+ binding to EF hands 1 and 3 is essential for the interaction of apoptosis-linked gene-2 with Alix/AIP1 in ocular melanoma. Biochemistry. 2004 Sep 7;43(35):11175-86. doi: 10.1021/bi048848d.PMID: 15366927 Moise AR, Kuksa V, Imanishi Y, Palczewski K. Identification of all-trans-retinol:all-trans-13,14-dihydroretinol saturase. J Biol Chem. 2004 Nov 26;279(48):50230-42. doi: 10.1074/jbc.M409130200. Epub 2004 Sep 9.PMID: 15358783 Liang Y, Fotiadis D, Maeda T, Maeda A, Modzelewska A, Filipek S, Saperstein DA, Engel A, Palczewski K. Rhodopsin signaling and organization in heterozygote rhodopsin knockout mice. J Biol Chem. 2004 Nov 12;279(46):48189-96. doi: 10.1074/jbc.M408362200. Epub 2004 Aug 26.PMID: 15337746 Mammen A, Simpson PJ, Nighorn A, Imanishi Y, Palczewski K, Ronnett GV, Moon C. Hippocalcin in the olfactory epithelium: a mediator of second messenger signaling. Biochem Biophys Res Commun. 2004 Oct 1;322(4):1131-9. doi: 10.1016/j.bbrc.2004.07.123.PMID: 15336960 Palczewski K, Sokal I, Baehr W. Guanylate cyclase-activating proteins: structure, function, and diversity. Biochem Biophys Res Commun. 2004 Oct 1;322(4):1123-30. doi: 10.1016/j.bbrc.2004.07.122.PMID: 15336959 Review. Imanishi Y, Gerke V, Palczewski K. Retinosomes: new insights into intracellular managing of hydrophobic substances in lipid bodies. J Cell Biol. 2004 Aug 16;166(4):447-53. doi: 10.1083/jcb.200405110.PMID: 15314061 Review. Filipek S, Krzysko KA, Fotiadis D, Liang Y, Saperstein DA, Engel A, Palczewski K. A concept for G protein activation by G protein-coupled receptor dimers: the transducin/rhodopsin interface. 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J Biol Chem. 2003 Jun 13;278(24):21655-21662. doi: 10.1074/jbc.M302536200. Epub 2003 Mar 27.PMID: 12663652 Mirzadegan T, Benkö G, Filipek S, Palczewski K. Sequence analyses of G-protein-coupled receptors: similarities to rhodopsin. Biochemistry. 2003 Mar 18;42(10):2759-67. doi: 10.1021/bi027224+.PMID: 12627940 Review. Fritze O, Filipek S, Kuksa V, Palczewski K, Hofmann KP, Ernst OP. Role of the conserved NPxxY(x)5,6F motif in the rhodopsin ground state and during activation. Proc Natl Acad Sci U S A. 2003 Mar 4;100(5):2290-5. doi: 10.1073/pnas.0435715100. Epub 2003 Feb 24.PMID: 12601165 Haeseleer F, Palczewski K. Calmodulin and Ca2+-binding proteins (CaBPs): variations on a theme. Adv Exp Med Biol. 2002;514:303-17. doi: 10.1007/978-1-4615-0121-3_18.PMID: 12596929 Review. Filipek S, Teller DC, Palczewski K, Stenkamp R. The crystallographic model of rhodopsin and its use in studies of other G protein-coupled receptors. 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