Publications Home Research Publications The Power of Knowledge The investigators in CTVR conduct high-power, well-funded, basic and translational research that results in publications in the most elite scientific journals. Andrew Browne, MD, PhD 2009-2025 Thomas JO, To JK, Riazi Esfahani P, Kruggel F, Tang WC, Browne AW. 3D ophthalmic ultrasonography at the slit lamp using existing ultrasound systems. PLoS One. 2025 Jan 28;20(1):e0317885. doi: 10.1371/journal.pone.0317885. PMID: 39874363; PMCID: PMC11774342. Thomas JO, To JK, Vu AN, Horton D, Dzihic E, Browne AW. Imaging performance of portable and conventional ultrasound imaging technologies for ophthalmic applications. PLoS One. 2024 May 13;19(5):e0300451. doi: 10.1371/journal.pone.0300451. PMID: 38739643; PMCID: PMC11090327. Browne AW*, Kim G*, Vu AN, To JK, Minckler DS, Estopinal MDV, Rao NA, Curcio CA, Baldi PF. Deep Learning Assisted Imaging Methods to Facilitate Access to Ophthalmic Telepathology. Ophthalmol Sci. 2023 Dec 12;4(3):100450. doi: 10.1016/j.xops.2023.100450. PMID: 38327842; PMCID: PMC10847934. * Denotes equal contribution Choi EH, Suh S, Sears AE, Hołubowicz R, Kedhar SR, Browne AW, Palczewski K. Genome editing in the treatment of ocular diseases. Exp Mol Med. 2023 Aug;55(8):1678-1690. doi: 10.1038/s12276-023-01057-2. Epub 2023 Aug 1. PMID: 37524870; PMCID: PMC10474087. Chen K, Browne AW. Radiation Retinopathy. Curr Ophthalmol Rep 11, 49–56 (2023). https://doi.org/10.1007/s40135-023-00313-y To JK, Vu AN, Ediriwickrema LS, Browne AW. Comparison of a custom Photogrammetry for Anatomical CarE (PHACE) system with other Low- Cost Facial Scanning Devices. medRxiv. 2023:2023.04.16.23288631. doi:10.1101/2023.04.16.23288631. To JK, Wang JN, Vu AN, Ediriwickrema LS, Browne AW. Optimization of a Novel Automated, Low Cost, Three-Dimensional Photogrammetry System (PHACE). medRxiv [Preprint]. 2023 Apr 21:2023.04.21.23288659. doi: 10.1101/2023.04.21.23288659. PMID: 37131650; PMCID: PMC10153329. White KM, Livnat I, Frambach CR, Doan J, Mehta UV, Yuh C, Palma AM, Jameson KA, Kenney MC, Mehta MC, Boisvert CJ, Crow WR, Browne AW. Quantitative cone contrast threshold testing in patients with differing pathophysiological mechanisms causing retinal diseases. Int J Retina Vitreous. 2023 Feb 2;9(1):9. doi: 10.1186/s40942-023-00442-3. PMID: 36732855; PMCID: PMC9893567. Baldi PF, Abdelkarim S, Liu J, To JK, Ibarra MD, Browne AW. Vitreoretinal Surgical Instrument Tracking in Three Dimensions Using Deep Learning. Transl Vis Sci Technol. 2023 Jan 3;12(1):20. doi: 10.1167/tvst.12.1.20. PMID: 36648414; PMCID: PMC9851279. Mehta U, Palczewska G, Lin KY, Browne AW. Seeing invisible light: 2-photon microperimetry to measure visual function. Am J Ophthalmol Case Rep. 2022 Oct 13;28:101724. doi: 10.1016/j.ajoc.2022.101724. PMID: 36324628; PMCID: PMC9619168. Xue Y, Lin B, Chen JT, Tang WC, Browne AW, Seiler MJ. The Prospects for Retinal Organoids in Treatment of Retinal Diseases. Asia Pac J Ophthalmol (Phila). 2022 Jul-Aug 01;11(4):314-327. doi: 10.1097/APO.0000000000000538. Epub 2022 Aug 30. PMID: 36041146; PMCID: PMC9966053. Jung JJ, Chang JS, Oellers PR, Ali MH, Do BK, Tseng JJ, Roizenblatt R, Muni RH, Weng CY, Oakey ZB, Tsao SW, Rofagha S, Chan X, Hoang QV; Young Retina Forum*. Impact of Coronavirus Disease 2019 Restrictions on Retinal Detachment: A Multicenter Experience. Ophthalmol Retina. 2022 Jul;6(7):638-641. doi: 10.1016/j.oret.2022.02.001. Epub 2022 Feb 7. PMID: 35144021; PMCID: PMC8820022. * Part of Young Retina Forum collaborators Himstead AS, Prasad J, Melucci S, Gustafson KM, Israelsen PE, Browne A. Feasibility of telemedicine program using a hand-held nonmydriatic retinal camera in Panama. Int J Ophthalmol. 2022 Jun 18;15(6):962-966. doi: 10.18240/ijo.2022.06.14. PMID: 35814905; PMCID: PMC9203467. Browne AW, Deyneka E, Ceccarelli F, To JK, Chen S, Tang J, Vu AN, Baldi PF. Deep learning to enable color vision in the dark. PLoS One. 2022 Apr 6;17(4):e0265185. doi: 10.1371/journal.pone.0265185. PMID: 35385502; PMCID: PMC8985995. Xue Y, Browne AW, Tang WC, Delgado J, McLelland BT, Nistor G, Chen JT, Chew K, Lee N, Keirstead HS, Seiler MJ. Retinal Organoids Long-Term Functional Characterization Using Two-Photon Fluorescence Lifetime and Hyperspectral Microscopy. Front Cell Neurosci. 2021 Dec 10;15:796903. doi: 10.3389/fncel.2021.796903. PMID: 34955757; PMCID: PMC8707055. McAleer S, Fast A, Xue Y, Seiler MJ, Tang WC, Balu M, Baldi P, Browne AW. Deep Learning-Assisted Multiphoton Microscopy to Reduce Light Exposure and Expedite Imaging in Tissues With High and Low Light Sensitivity. Transl Vis Sci Technol. 2021 Oct 4;10(12):30. doi: 10.1167/tvst.10.12.30. PMID: 34668935; PMCID: PMC8543395. Xue Y, Seiler MJ, Tang WC, Wang JY, Delgado J, McLelland BT, Nistor G, Keirstead HS, Browne AW. Retinal organoids on-a-chip: a micro-millifluidic bioreactor for long-term organoid maintenance. Lab Chip. 2021 Sep 7;21(17):3361-3377. doi: 10.1039/d1lc00011j. Epub 2021 Jul 8. PMID: 34236056; PMCID: PMC8387452. Wei A, Mehta UV, Palczewska G, Palma AM, Hussey VM, Hoffmann LE, Diep A, Nguyen K, Le B, Chang SY, Browne AW. Two-Photon Microperimetry: A Media Opacity-Independent Retinal Function Assay. Transl Vis Sci Technol. 2021 Feb 5;10(2):11. doi: 10.1167/tvst.10.2.11. PMID: 34003895; PMCID: PMC7881275. Mehta U, Diep A, Nguyen K, Le B, Yuh C, Frambach C, Doan J, Wei A, Palma AM, Farid M, Garg S, Kedhar S, Wade M, Marshall KA, Jameson KA, Cristina Kenney M, Browne AW. Quantifying Color Vision Changes Associated With Cataracts Using Cone Contrast Thresholds. Transl Vis Sci Technol. 2020 Nov 3;9(12):11. doi: 10.1167/tvst.9.12.11. PMID: 33200052; PMCID: PMC7645251. Bhatter P, Cao L, Crochetiere A, Raefsky SM, Cuevas LR, Enendu K, Frisch EH, Shumway C, Gore C, Browne AW. Using a Macro Lens for Anterior Segment Imaging in Rural Panama. Telemed J E Health. 2020 Nov;26(11):1414-1418. doi: 10.1089/tmj.2019.0152. Epub 2020 Feb 7. PMID: 32031913; PMCID: PMC7698642. Oertel FC, Zeitz O, Rönnefarth M, Bereuter C, Motamedi S, Zimmermann HG, Kuchling J, Grosch AS, Doss S, Browne AW, Paul F, Schmitz-Hübsch T, Brandt AU. Functionally Relevant Maculopathy and Optic Atrophy in Spinocerebellar Ataxia Type 1. Mov Disord Clin Pract. 2020 May 6;7(5):502-508. doi: 10.1002/mdc3.12949. PMID: 32626794; PMCID: PMC7328427. Browne AW, Ansari W, Hu M, Baynes K, Lowder CY, Ehlers JP, Srivastava SK. Quantitative Analysis of Ellipsoid Zone in Acute Posterior Multifocal Placoid Pigment Epitheliopathy. J Vitreoretin Dis. 2020 Jun 1;4(3):192-201. doi: 10.1177/2474126420901897. Epub 2020 Feb 11. PMID: 34084990; PMCID: PMC8171299. Li Y, Zhu J, Chen JJ, Yu J, Jin Z, Miao Y, Browne AW, Zhou Q, Chen Z. Simultaneously imaging and quantifying in vivo mechanical properties of crystalline lens and cornea using optical coherence elastography with acoustic radiation force excitation. APL Photonics. 2019 Oct;4(10):106104. doi: 10.1063/1.5118258. Epub 2019 Oct 8. PMID: 32309636; PMCID: PMC7164808. Feiler DL, Browne AW, Rachitskaya AV, Taban M, Sonnie C, Hayden-Loreck BC, Sharma S, Sears JE. Indirect Cyclopexy for Repair of Cyclodialysis Clefts. Retina. 2019 Oct;39 Suppl 1:S177-S181. doi: 10.1097/IAE.0000000000002091. PMID: 29543634. Ramos MS, Echegaray JJ, Kuhn-Asif S, Wilkinson A, Yuan A, Singh AD, Browne AW. Animal models of radiation retinopathy - From teletherapy to brachytherapy. Exp Eye Res. 2019 Apr;181:240-251. doi: 10.1016/j.exer.2019.01.019. Epub 2019 Feb 1. PMID: 30716328. Browne AW, Ehlers JP, Sharma S, Srivastava SK. Intraoperative Optical Coherence Tomography-Assisted Chorioretinal Biopsy in the DISCOVER Study. Retina. 2017 Nov;37(11):2183-2187. doi: 10.1097/IAE.0000000000001522. PMID: 28426625; PMCID: PMC5648642. Browne AW, Arnesano C, Harutyunyan N, Khuu T, Martinez JC, Pollack HA, Koos DS, Lee TC, Fraser SE, Moats RA, Aparicio JG, Cobrinik D. Structural and Functional Characterization of Human Stem-Cell-Derived Retinal Organoids by Live Imaging. Invest Ophthalmol Vis Sci. 2017 Jul 1;58(9):3311-3318. doi: 10.1167/iovs.16-20796. PMID: 28672397; PMCID: PMC5495152. Valenzuela F, Browne AW, Srur M, Nieme C, Zanolli M, López-Solís R, Traipe L. Combined Phacoemulsification and Ahmed Glaucoma Drainage Implant Surgery for Patients With Refractory Glaucoma and Cataract. J Glaucoma. 2016 Feb;25(2):162-6. doi: 10.1097/IJG.0000000000000141. PMID: 25264992. Browne AW, Dandapani SV, Jennelle R, Stevanovic M, Lee TC, Murphree AL, Kampp TD, Astrahan MA, Kim JW, Berry JL. Outcomes of medium choroidal melanomas treated with ruthenium brachytherapy guided by three-dimensional pretreatment modeling. Brachytherapy. 2015 Sep-Oct;14(5):718-25. doi: 10.1016/j.brachy.2015.04.010. Epub 2015 Jun 12. PMID: 26073224. Papu JT, Rust MJ, Browne AW. A Portable Centrifuge for Point-of-Care Measurement of Hematocrit in Low-Resource Settings. Point of Care. 2014 Jun;13(2):48-53. doi: 10.1097/POC.0000000000000012 Browne AW, Osher RH. Optimizing precision in toric lens selection by combining keratometry techniques. J Refract Surg. 2014 Jan;30(1):67-72. doi: 10.3928/1081597X-20131217-07. PMID: 24864329. Browne AW, Ahn CH. An in-line microfluidic blood sampling interface between patients and saline infusion systems. Biomed Microdevices. 2011 Aug;13(4):661-9. doi: 10.1007/s10544-011-9536-4. PMID: 21465091. Browne AW, Ramasamy L, Cripe TP, Ahn CH. A lab-on-a-chip for rapid blood separation and quantification of hematocrit and serum analytes. Lab Chip. 2011 Jul 21;11(14):2440-6. doi: 10.1039/c1lc20144a. Epub 2011 Jun 8. PMID: 21655589. Browne AW, Leddon JL, Currier MA, Williams JP, Frischer JS, Collins MH, Ahn CH, Cripe TP. Cancer screening by systemic administration of a gene delivery vector encoding tumor-selective secretable biomarker expression. PLoS One. 2011 May 11;6(5):e19530. doi: 10.1371/journal.pone.0019530. PMID: 21589655; PMCID: PMC3092745. Shim JS, Browne AW, Ahn CH. An on-chip whole blood/plasma separator with bead-packed microchannel on COC polymer. Biomed Microdevices. 2010 Oct;12(5):949-57. doi: 10.1007/s10544-010-9449-7. PMID: 20563751. Browne AW, Hitchcock KE, Ahn CH. A PDMS pinch-valve module embedded in rigid polymer lab chips for on-chip flow regulation. J. Micromech. Microeng. Oct 2009; 19(11). doi: 10.1088/0960-1317/19/11/115012. Browne AW, Rust MJ, Jung W, Lee SH, Ahn CH. A rapid prototyping method for polymer microfluidics with fixed aspect ratio and 3D tapered channels. Lab Chip. 2009 Oct 21;9(20):2941-6. doi: 10.1039/b903755a. Epub 2009 Jul 14. PMID: 19789747. Rui Chen, PhD 2023-2025 Hussain H Muhammad J, Wang M, Huang A, Schmidt R, Qian X, Yang P, Marra M, Li Y, Pennesi ME, Chen R. Novel Pathogenic Mutations Identified from Whole-Genome Sequencing in Unsolved Cases of Patients Affected with Inherited Retinal Diseases. Genes (Basel). 2023 ;14(2). 447. doi: 10.3390/genes14020447. PMID: 36833373; PMCID: PMC9956865. Wen S, Wang M, Qian X, Li Y, Wang K, Choi J, Pennesi ME, Yang P, Marra M, Koenekoop RK, Lopez I, Matynia A, Gorin M, Sui R, Yao F, Goetz K, Porto FBelga Otto, Chen R. Systematic assessment of the contribution of structural variants to inherited retinal diseases. Hum Mol Genet. 2023 Jun 5;32(12):2005-2015. doi: 10.1093/hmg/ddad032. PMID: 36811936; PMCID: PMC10244226. Chen Q, Sasikala-Appukuttan AK, Husain Z, Shrivastava A, Spain M, Sendler ED, Daines B, Fischer S, Chen R, Cook TA, Friedrich M. Global Gene Expression Analysis Reveals Complex Cuticle Organization of the Tribolium Compound Eye. Genome Biol Evol. 2023 Jan 4;15(1):evac181. doi: 10.1093/gbe/evac181. PMID: 36575057; PMCID: PMC9866248. Qian X, Srinivasan T, He J, Lu J, Jin Y, Gu H, Chen R. Ceramide compensation by ceramide synthases preserves retinal function and structure in a retinal dystrophy mouse model. Dis Model Mech. 2023 Jul 1;16(7):dmm050168. doi: 10.1242/dmm.050168. Epub 2023 Jul 19. PMID: 37466006; PMCID: PMC10387349. Lu J, Zheng KQ, Bertrand RE, Quinlan J, Ferdous S, Srinivasan T, Oh S, Wang K, Chen R. Gene augmentation therapy to rescue degenerative photoreceptors in a Cwc27 mutant mouse model. Exp Eye Res. 2023 Jul 20;234:109596. doi: 10.1016/j.exer.2023.109596. Epub ahead of print. PMID: 37479075. Fu S, Fu J, Mobasher-Jannat A, Jadidi K, Li Y, Chen R, Imani S, Cheng J. Novel pathogenic CERKL variant in Iranian familial with inherited retinal dystrophies: genotype-phenotype correlation. 3 Biotech. 2023 Jun;13(6):166. doi: 10.1007/s13205-023-03535-w. Epub 2023 May 6. PMID: 37162806; PMCID: PMC10163994. Hernández-García A, Pendleton KE, Kim S, Li Y, Kim BJ, Zaveri HP, Jordan VK, Berry AM, Ljungberg MC, Chen R, Lanz RB, Scott DA. SOX7 deficiency causes ventricular septal defects through its effects on endocardial-to-mesenchymal transition and the expression of Wnt4 and Bmp2. Hum Mol Genet. 2023 Jun 19;32(13):2152-2161. doi: 10.1093/hmg/ddad050. PMID: 37000005; PMCID: PMC10281751. Sin TN, Kim S, Li Y, Wang J, Chen R, Chung SH, Kim S, Casanova MI, Park S, Smit-McBride Z, Sun N, Pomerantz O, Roberts JA, Guan B, Hufnagel RB, Moshiri A, Thomasy SM, Sieving PA, Yiu G. A Spontaneous Nonhuman Primate Model of Myopic Foveoschisis. Invest Ophthalmol Vis Sci. 2023 Jan 3;64(1):18. doi: 10.1167/iovs.64.1.18. PMID: 36689233; PMCID: PMC9896856. Liang Q, Cheng X, Wang J, Owen L, Shakoor A, Lillvis JL, Zhang C, Farkas M, Kim IK, Li Y, DeAngelis M, Chen R. A multi-omics atlas of the human retina at single-cell resolution. Cell Genom. 2023 Apr 11;3(6):100298. doi: 10.1016/j.xgen.2023.100298. PMID: 37388908; PMCID: PMC10300490. Dou J, Tan Y, Kock KH, Wang J, Cheng X, Tan LM, Han KY, Hon CC, Park WY, Shin JW, Jin H, Wang Y, Chen H, Ding L, Prabhakar S, Navin N, Chen R, Chen K. Single-nucleotide variant calling in single-cell sequencing data with Monopogen. Nat Biotechnol. 2023 Aug 17. doi: 10.1038/s41587-023-01873-x PMID: 37592035. Choi J, Li J, Ferdous S, Liang Q, Moffitt JR, Chen R. Spatial organization of the mouse retina at single cell resolution by MERFISH. Nat Commun. 2023 Aug 15;14(1):4929. doi: 10.1038/s41467-023-40674-3. PMID: 37582959; PMCID: PMC10427710. Jun Wang, Xuesen Cheng, Qingnan Liang, Leah A. Owen, Jiaxiong Lu, Yiqiao Zheng, Meng Wang, Shiming Chen, Margaret M. DeAngelis, Yumei Li, Rui Chen Single-cell multiomics of the human retina reveals hierarchical transcription factor collaboration in mediating cell type-specific effects of genetic variants on gene regulation Genome Biology, 2023 accepted DOI : 10.1186/s13059-023-03111-8 Han JH, Rodenburg K, Hayman T, Calzetti G, Kaminska K, Quinodoz M, Marra M, Wallerich S, Allon G, Nagy ZZ, Knézy K, Li Y, Chen R, Barboni MTS, Yang P, Pennesi ME, van den Born LI, Varsányi B, Szabó V, Sharon D, Banin E, Ben-Yosef T, Roosing S, Koenekoop RK, Rivolta C. Loss-of-function variants in UBAP1L cause autosomal recessive retinal degeneration. Genet Med. 2024 Feb 26:101106. doi: 10.1016/j.gim.2024.101106. Epub ahead of print. PMID: 38420906. Brock DC, Wang M, Hussain HMJ, Rauch DE, Marra M, Pennesi ME, Yang P, Everett L, Ajlan RS, Colbert J, Porto FBO, Matynia A, Gorin MB, Koenekoop RK, Lopez I, Sui R, Zou G, Li Y, Chen R. Comparative analysis of in-silico tools in identifying pathogenic variants in dominant inherited retinal diseases. Hum Mol Genet. 2024 Mar 7:ddae028. doi: 10.1093/hmg/ddae028. Epub ahead of print. PMID: 38453143. Alam J, Yaman E, Silva GCV, Chen R, de Paiva CS, Stepp MA, Pflugfelder SC. Single cell analysis of short-term dry eye induced changes in cornea immune cell populations. Front Med (Lausanne). 2024 Apr 25;11:1414997. doi: 10.3389/fmed.2024.1414997. PMID: 38560382; PMCID: PMC10978656. Wang J, Wang M, Moshiri A, Harris RA, Raveendran M, Nguyen T, Kim S, Young L, Wang K, Wiseman R, O'Connor DH, Johnson Z, Martinez M, Montague MJ, Sayers K, Lyke M, Vallender E, Stout T, Li Y, Thomasy SM, Rogers J, Chen R. Genetic diversity of 1,845 rhesus macaques improves genetic variation interpretation and identifies disease models. Nat Commun. 2024 Jul 5;15(1):5658. doi: 10.1038/s41467-024-49922-6. PMID: 38969634; PMCID: PMC11226599. Raja KKB, Yeung K, Li Y, Chen R, Mardon G. A single cell RNA sequence atlas of the early Drosophila larval eye. BMC Genomics. 2024 Jun 19;25(1):616. doi: 10.1186/s12864-024-10423-x. PMID: 38890587; PMCID: PMC11186242. Li J, Choi J, Cheng X, Ma J, Pema S, Sanes JR, Mardon G, Frankfort BJ, Tran NM, Li Y, Chen R. Comprehensive single-cell atlas of the mouse retina. iScience. 2024 May 8;27(6):109916. doi: 10.1016/j.isci.2024.109916. PMID: 38812536; PMCID: PMC11134544. Zuo Z, Cheng X, Ferdous S, Shao J, Li J, Bao Y, Li J, Lu J, Jacobo Lopez A, Wohlschlegel J, Prieve A, Thomas MG, Reh TA, Li Y, Moshiri A, Chen R. Single cell dual-omic atlas of the human developing retina. Nat Commun. 2024 Aug 9;15(1):6792. doi: 10.1038/s41467-024-50853-5. PMID: 39117640; PMCID: PMC11310509. Justin Ma, Ting-Kuan Chu, Maria Polo-Prieto, Yong H. Park, Yumei Li, Rui Chen, Graeme Mardon, Benjamin J. Frankfort, Nicholas M. Tran Sample multiplexing for retinal single-cell RNA sequencing. iScience, Volume 27, Issue 11, 2024, 111250 Akhtar, Z., Altaf, S., Li, Y., Bibi, S., Shah, J., Afshan, K., Wang, M., Hussain, H. M. J., Qureshi, N., Chen, R (Co-corresponding)., & Firasat, S. (2024). Phenotypic and Genetic Heterogeneity of a Pakistani Cohort of 15 Consanguineous Families Segregating Variants in Leber Congenital Amaurosis-Associated Genes. Genes, 15(12), 1646. https://doi.org/10.3390/genes15121646 Li Y, Zhou X, Chen R, Zhang X, Cao H. STAREG: Statistical replicability analysis of high throughput experiments with applications to spatial transcriptomic studies. PLoS Genet. 2024 Oct 3;20(10):e1011423. doi: 10.1371/journal.pgen.1011423. PMID: 39361716; PMCID: PMC11478871. Xie Z, Zhang T, Kim S, Lu J, Zhang W, Lin CH, Wu MR, Davis A, Channa R, Giancardo L, Chen H, Wang S, Chen R (Co-corresponding), Zhi D. iGWAS: Image-based genome-wide association of self-supervised deep phenotyping of retina fundus images. PLoS Genet. 2024 May 10;20(5):e1011273. doi: 10.1371/journal.pgen.1011273. PMID: 38728357; PMCID: PMC11111076. Hamel AR, Yan W, Rouhana JM, Monovarfeshani A, Jiang X, Mehta PA, Advani J, Luo Y, Liang Q, Rajasundaram S, Shrivastava A, Duchinski K, Mantena S, Wang J, van Zyl T, Pasquale LR, Swaroop A, Gharahkhani P, Khawaja AP, MacGregor S; International Glaucoma Genetics Consortium (IGGC); Chen R, Vitart V, Sanes JR, Wiggs JL, Segrè AV. Integrating genetic regulation and single-cell expression with GWAS prioritizes causal genes and cell types for glaucoma. Nat Commun. 2024 Jan 9;15(1):396. doi: 10.1038/s41467-023-44380-y. PMID: 38195602; PMCID: PMC10776627. Xu L, Peng F, Luo Q, Ding Y, Yuan F, Zheng L, He W, Zhang SS, Fu X, Liu J, Mutlu AS, Wang S, Nehring RB, Li X, Tang Q, Li C, Lv X, Dobrolecki LE, Zhang W, Han D, Zhao N, Jaehnig E, Wang J, Wu W, Graham DA, Li Y, Chen R, Peng W, Chen Y, Catic A, Zhang Z, Zhang B, Mustoe AM, Koong AC, Miles G, Lewis MT, Wang MC, Rosenberg SM, O'Malley BW, Westbrook TF, Xu H, Zhang XH, Osborne CK, Li JB, Ellis MJ, Rimawi MF, Rosen JM, Chen X. IRE1α silences dsRNA to prevent taxane-induced pyroptosis in triple-negative breast cancer. Cell. 2024 Dec 12;187(25):7248-7266.e34. doi: 10.1016/j.cell.2024.09.032. Epub 2024 Oct 16. PMID: 39419025; PMCID: PMC11645245. Guo S, Liu X, Cheng X, Jiang Y, Ji S, Liang Q, Koval A, Li Y, Owen LA, Kim IK, Aparicio A, Lee S, Sood AK, Kopetz S, Shen JP, Weinstein JN, DeAngelis MM, Chen R, Wang W. A deconvolution framework that uses single-cell sequencing plus a small benchmark dataset for accurate analysis of cell type ratios in complex tissue samples. Genome Res. 2024 Nov 25:gr.278822.123. doi: 10.1101/gr.278822.123. Epub ahead of print. PMID: 39586714. 2019-2022 Kim S, Lowe A, Dharmat R, Lee S, Owen LA, Wang J, Shakoor A, Li Y, Morgan DJ, Hejazi AA, Cvekl A, DeAngelis MM, Zhou ZJ, Chen R*, Liu W. Generation, transcriptome profiling, and functional validation of cone-rich human retinal organoids. Proc Natl Acad Sci U S A. 2019 May 28;116(22):10824-10833. Kwon OJ, Zhang Y, Li Y, Wei X, Zhang L, Chen R, Creighton CJ, Xin L. Functional Heterogeneity of Mouse Prostate Stromal Cells Revealed by Single-Cell RNA-Seq. iScience. 2019 Mar 29;13:328-338. doi: 10.1016/j.isci.2019.02.032. Epub 2019 Mar 2 Moshiri A, Chen R*, Kim S, Harris RA, Li Y, Raveendran M, Davis S, Liang Q, Pomerantz O, Wang J, Garzel L, Cameron A, Yiu G, Stout JT, Huang Y, Murphy CJ, Roberts J, Gopalakrishna KN, Boyd K, Artemyev NO, Rogers J, Thomasy SM. A nonhuman primate model of inherited retinal disease. J Clin Invest. 2019 Feb 1;129(2):863-874. doi: 10.1172/JCI123980. Epub 2019 Jan 22. PMID: 30667376 PMCID: PMC6355306 Kean TJ, Ge Z, Li Y, Chen R, Dennis JE. Transcriptome-Wide Analysis of Human Chondrocyte Expansion on Synoviocyte Matrix. Cells. 2019 Jan 24;8(2). pii: E85. doi: 10.3390/cells8020085. PMID: 30678371 Alabduljalil T, Patel RC, Alqahtani AA, Gao SS, Gale MJ, Zhang M, Jia Y, Huang D, Chiang PW, Chen R, Wang J, Weleber RG, Pennesi ME, Yang P. Correlation of Outer Retinal Degeneration and Choriocapillaris Loss in Stargardt Disease Using En Face Optical Coherence Tomography and Optical Coherence Tomography Angiography. Am J Ophthalmol. 2019 Jun;202:79-90 Bader DA, Hartig SM, Putluri V, Foley C, Hamilton MP, Smith EA, Saha PK, Panigrahi A, Walker C, Zong L, Martini-Stoica H, Chen R, Rajapakshe K, Coarfa C, Sreekumar A, Mitsiades N, Bankson JA, Ittmann MM, O'Malley BW, Putluri N, McGuire SE. Mitochondrial pyruvate import is a metabolic vulnerability in androgen receptor-driven prostate cancer. Nat Metab. 2019 Jan;1(1):70-85. PMID: 31198906 PMCID: PMC6563330 Park YH, Snook JD, Ostrin EJ, Kim S, Chen R, Frankfort BJ. Transcriptomic profiles of retinal ganglion cells are defined by the magnitude of intraocular pressure elevation in adult mice. Sci Rep. 2019 Feb 22;9(1):2594. doi: 10.1038/s41598-019-39141-1. PMID: 30796289 PMCID: PMC6385489 Gunasekara CJ, Scott CA, Laritsky E, Baker MS, MacKay H, Duryea JD, Kessler NJ, Hellenthal G, Wood AC, Hodges KR, Gandhi M, Hair AB, Silver MJ, Moore SE, Prentice AM, Li Y, Chen R, Coarfa C, Waterland RA. A genomic atlas of systemic interindividual epigenetic variation in humans. Genome Biol. 2019 Jun 3;20(1):105. doi: 10.1186/s13059-019-1708-1. PMID: 31155008 PMCID: PMC6545702 Aguirre LE, Colleluori G, Robbins D, Dorin R, Shah VO, Chen R, Jan IZ, Qualls C, Villareal DT, Armamento-Villareal R. 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Next-generation sequencing-based molecular diagnosis of 35 Hispanic retinitis pigmentosa probands. Sci Rep. 2016 Sep 6;6:32792. doi: 10.1038/srep32792. PMID: 27596865 , PMCID:PMC5011706, Impact factor:5.228 Zhang B, Kwon OJ, Henry G, Malewska A, Wei X, Zhang L, Brinkley W, Zhang Y, Castro PD, Titus M, Chen R, Sayeeduddin M, Raj GV, Mauck R, Roehrborn C, Creighton CJ, Strand DW, Ittmann MM, Xin L. Non-Cell-Autonomous Regulation of Prostate Epithelial Homeostasis by Androgen Receptor. Mol Cell. 2016 Sep 15;63(6):976-89. doi: 10.1016/j.molcel.2016.07.025. Epub 2016 Sep 1. PMID: 27594448 , PMCID:PMC5026614, Impact factor:13.958 Coppieters F, Ascari G, Dannhausen K, Nikopoulos K, Peelman F, Karlstetter M, Xu M, Brachet C, Meunier I, Tsilimbaris MK, Tsika C, Blazaki SV, Vergult S, Farinelli P, Van Laethem T, Bauwens M, De Bruyne M, Chen R, Langmann T, Sui R, Meire F, Rivolta C, Hamel CP, Leroy BP, De Baere E. Isolated and Syndromic Retinal Dystrophy Caused by Biallelic Mutations in RCBTB1, a Gene Implicated in Ubiquitination. Am J Hum Genet. 2016 Aug 4;99(2):470-80. doi: 10.1016/j.ajhg.2016.06.017. PMID: 27486781 , PMCID:PMC4974088, Impact factor:11.202 Hull S, Arno G, Ku CA, Ge Z, Waseem N, Chandra A, Webster AR, Robson AG, Michaelides M, Weleber RG, Davagnanam I, Chen R, Holder GE, Pennesi ME, Moore AT. Molecular and Clinical Findings in Patients With Knobloch Syndrome. JAMA Ophthalmol. 2016 Jul 1;134(7):753-62. doi: 10.1001/jamaophthalmol.2016.1073. PMID: 27259167, Impact factor:4.3 Han X, Liu Z, Zhao L, Wang F, Yu Y, Yang J, Chen R, Qin L. Microfluidic Cell Deformability Assay for Rapid and Efficient Kinase Screening with the CRISPR-Cas9 System. Angew Chem Int Ed Engl. 2016 Jul 18;55(30):8561-5. doi: 10.1002/anie.201601984. Epub 2016 Jun 3. PMID: 27258939 , PMCID:PMC4945455, Impact factor:11.709 Jin M, Eblimit A, Pulikkathara M, Corr S, Chen R, Mardon G. Conditional knockout of retinal determination genes in differentiating cells in Drosophila. FEBS J. 2016 Aug;283(15):2754-66. doi: 10.1111/febs.13772. Epub 2016 Jun 23. PMID: 27257739 , PMCID:PMC4975629, Impact factor:3.519 Jin M, Aibar S, Ge Z, Chen R, Aerts S, Mardon G. Identification of novel direct targets of Drosophila Sine oculis and Eyes absent by integration of genome-wide data sets. Dev Biol. 2016 Jul 1;415(1):157-67. doi: 10.1016/j.ydbio.2016.05.007. Epub 2016 May 10. PMID: 27178668 , PMCID:PMC4902760, Impact factor:3.547 Pew BK, Harris RA, Sbrana E, Guaman MC, Shope C, Chen R, Meloche S, Aagaard K.Structural and transcriptomic response to antenatal corticosteroids in an Erk3-null mouse model of respiratory distress. Am J Obstet Gynecol. 2016 Sep;215(3):384.e1-384.e89. doi: 10.1016/j.ajog.2016.04.043. Epub 2016 Apr 30. PMID: 27143398 , PMCID:PMC5003661, Impact factor:4.704 Xu M, Yamada T, Sun Z, Eblimit A, Lopez I, Wang F, Manya H, Xu S, Zhao L, Li Y, Kimchi A, Sharon D, Sui R, Endo T, Koenekoop RK, Chen R. Mutations in POMGNT1 cause non-syndromic retinitis pigmentosa. Hum Mol Genet. 2016 Apr 15;25(8):1479-88. doi: 10.1093/hmg/ddw022. Epub 2016 Jan 28. PMID: 26908613 , PMCID: PMC4805308, Impact factor:6.393 Arno G, Agrawal SA, Eblimit A, Bellingham J, Xu M, Wang F, Chakarova C, Parfitt DA, Lane A, Burgoyne T, Hull S, Carss KJ, Fiorentino A, Hayes MJ, Munro PM, Nicols R, Pontikos N, Holder GE; UKIRDC., Asomugha C, Raymond FL, Moore AT, Plagnol V, Michaelides M, Hardcastle AJ, Li Y, Cukras C, Webster AR, Cheetham ME, Chen R. Mutations in REEP6 Cause Autosomal-Recessive Retinitis Pigmentosa. Am J Hum Genet. 2016 Dec 1;99(6):1305-1315. doi: 10.1016/j.ajhg.2016.10.008. PMID: 27889058 Zhang B, Kwon OJ, Henry G, Malewska A, Wei X, Zhang L, Brinkley W, Zhang Y, Castro PD, Titus M, Chen R, Sayeeduddin M, Raj GV, Mauck R, Roehrborn C, Creighton CJ, Strand DW, Ittmann MM, Xin L. Non-Cell-Autonomous Regulation of Prostate Epithelial Homeostasis by Androgen Receptor. Mol Cell. 2016 Sep 15;63(6):976-89. doi: 10.1016/j.molcel.2016.07.025. PMID: 27594448 Breman AM, Chow JC, U'Ren L, Normand EA, Qdaisat S, Zhao L, Henke DM, Chen R, Shaw CA, Jackson L, Yang Y, Vossaert L, Needham RH, Chang EJ, Campton D, Werbin JL, Seubert RC, Van den Veyver IB, Stilwell JL, Kaldjian EP, Beaudet AL. Evidence for feasibility of fetal trophoblastic cell-based noninvasive prenatal testing. Prenat Diagn. 2016 Nov;36(11):1009-1019. doi: 10.1002/pd.4924. PMID: 27616633 Kølvraa S, Singh R, Normand EA, Qdaisat S, van den Veyver IB, Jackson L, Hatt L, Schelde P, Uldbjerg N, Vestergaard EM, Zhao L, Chen R, Shaw CA, Breman AM, Beaudet AL. Genome-wide copy number analysis on DNA from fetal cells isolated from the blood of pregnant women. Prenat Diagn. 2016 Dec;36(12):1127-1134. doi: 10.1002/pd.4948. PMID: 27761919 Tan H, Deng B, Yu H, Yang Y, Ding L, Zhang Q, Qin J, Kijlstra A, Chen R, Yang P. Genetic analysis of innate immunity in Behcet's disease identifies an association with IL-37 and IL-18RAP. Sci Rep. 2016 Oct 24;6:35802. doi: 10.1038/srep35802. PMID: 27775096 Zhang K, Gao M, Chong Z, Li Y, Han X, Chen R, Qin L. Single-cell isolation by a modular single-cell pipette for RNA-sequencing. Lab Chip. 2016 Nov 29;16(24):4742-4748. PMID: 27841430 Ventura MJ, Wheaton D, Xu M, Birch D, Bowne SJ, Sullivan LS, Daiger SP, Whitney AE, Jones RO, Moser AB, Chen R, Wangler MF. Diagnosis of a mild peroxisomal phenotype with next-generation sequencing. Mol Genet Metab Rep. 2016 Nov 11;9:75-78. PMID: 27872819 Xue C, Raveendran M, Harris RA, Fawcett GL, Liu X, White S, Dahdouli M, Rio Deiros D, Below JE, Salerno W, Cox L, Fan G, Ferguson B, Horvath J, Johnson Z, Kanthaswamy S, Kubisch HM, Liu D, Platt M, Smith DG, Sun B, Vallender EJ, Wang F, Wiseman RW, Chen R, Muzny DM, Gibbs RA, Yu F, Rogers J. The population genomics of rhesus macaques (Macaca mulatta) based on whole-genome sequences. Genome Res. 2016 Dec;26(12):1651-1662. PMID: 27934697 Keser V, Khan A, Siddiqui S, Lopez I, Ren H, Qamar R, Nadaf J, Majewski J, Chen R, Koenekoop RK. The Genetic Causes of Nonsyndromic Congenital Retinal Detachment: A Genetic and Phenotypic Study of Pakistani Families. Invest Ophthalmol Vis Sci. 2017 Feb 1;58(2):1028-1036. doi: 10.1167/iovs.16-20281. PMID: 28192794 Free PMC Article Gui S, Rice AP, Chen R, Wu L, Liu J, Miao H. A scalable algorithm for structure identification of complex gene regulatory network from temporal expression data. BMC Bioinformatics. 2017 Jan 31;18(1):74. doi: 10.1186/s12859-017-1489-z. PMID: 28143596 Free PMC Article Dharmat R, Liu W, Ge Z, Sun Z, Yang L, Li Y, Wang K, Thomas K, Sui R, Chen R. IFT81 as a Candidate Gene for Nonsyndromic Retinal Degeneration. Invest Ophthalmol Vis Sci. 2017 May 1;58(5):2483-2490 PMID: 28460050 PMCID: PMC5413215 Xu M, Xie YA, Abouzeid H, Gordon CT, Fiorentino A, Sun Z, Lehman A, Osman IS, Dharmat R, Riveiro-Alvarez R, Bapst-Wicht L, Babino D, Arno G, Busetto V, Zhao L, Li H, Lopez-Martinez MA, Azevedo LF, Hubert L, Pontikos N, Eblimit A1, Lorda-Sanchez , Kheir V, Plagnol V, Oufadem M, Soens ZT1, Yang L, Bole-Feysot C, Pfundt R, Allaman-Pillet N, Nitschké P, Cheetham ME, Lyonnet S, Agrawal SA, Li H, Pinton G, Michaelides M, Besmond C, Li Y, Yuan Z, von Lintig J, Webster AR, Le Hir H, Stoilov P; UK Inherited Retinal Dystrophy Consortium, Amiel J, Hardcastle AJ, Ayuso C, Sui R, Chen R (co corresponding), Allikmets R, Schorderet DF Mutations in the Spliceosome Component CWC27 Cause Retinal Degeneration with or without Additional Developmental Anomalies. Am J Hum Genet. 2017 Apr 6;100(4):592-604 PMID: 28285769 PMCID: PMC5384039 Chen Y, Zhao L, Wang Y, Cao M, Gelowani V, Xu M, Agrawal SA, Li Y, Daiger SP, Gibbs R, Wang F, Chen R SeqCNV: a novel method for identification of copy number variations in targeted next-generation sequencing data BMC Bioinformatics. 2017 Mar 3;18(1):147 PMID: 28253855 PMCID: PMC5335817 Yuan Z, Li B, Xu M, Chang EY, Li H, Yang L, Wu S, Soens ZT, Li Y, Wong LC, Lewis RA, Sui R, Chen R The phenotypic variability of HK1-associated retinal dystrophy. Sci Rep. 2017 Aug 1;7(1):7051. PMID: 28765615 PMCID: PMC5539152 Jones KD, Wheaton DK, Bowne SJ, Sullivan LS, Birch DG, Chen R, Daiger SP Next-generation sequencing to solve complex inherited retinal dystrophy: A case series of multiple genes contributing to disease in extended families. Mol Vis. 2017 Jul 20;23:470-481 PMID: 28761320 PMCID: PMC5524430 Soens ZT, Branch J, Wu S, Yuan Z, Li Y, Li H, Wang K, Xu M, Rajan L, Motta FL, Simões RT, Lopez-Solache I, Ajlan R, Birch DG, Zhao P, Porto FB, Sallum J, Koenekoop RK, Sui R, Chen R. Leveraging splice-affecting variant predictors and a minigene validation system to identify Mendelian disease-causing variants among exon-captured variants of uncertain significance. Hum Mutat. 2017. PMID: 28714225 Sullivan LS, Bowne SJ, Koboldt DC, Cadena EL, Heckenlively JR, Branham KE, Wheaton DH, Jones KD, Ruiz RS, Pennesi ME, Yang P, Davis-Boozer D, Northrup H, Gurevich VV, Chen R, Xu M, Li Y, Birch DG, Daiger SP. A Novel Dominant Mutation in SAG, the Arrestin-1 Gene, Is a Common Cause of Retinitis Pigmentosa in Hispanic Families in the Southwestern United States. Invest Ophthalmol Vis Sci. 2017 May 1;58(5):2774-2784. PMID: 28549094 Agrawal SA, Burgoyne T, Eblimit A, Bellingham J, Parfitt DA, Lane A, Nichols R, Asomugha C, Hayes MJ, Munro PM, Xu M, Wang K, Futter CE, Li Y, Chen R (co-corresponding), Cheetham ME. REEP6 deficiency leads to retinal degeneration through disruption of ER homeostasis and protein trafficking. Hum Mol Genet. 2017 Jul 15;26(14):2667-2677 PMID: 28475715 Zeng HC, Bae Y, Dawson BC, Chen Y, Bertin T, Munivez E, Campeau PM, Tao J, Chen R, Lee BH. MicroRNA miR-23a cluster promotes osteocyte differentiation by regulating TGF-β signalling in osteoblasts. Nat Commun. 2017 Apr 11;8:15000. PMID: 28397831 LeBlanc ME, Wang W, Chen X, Caberoy NB, Guo F, Shen C, Ji Y, Tian H, Wang H, Chen R, Li W. Secretogranin III as a disease-associated ligand for antiangiogenic therapy of diabetic retinopathy. J Exp Med. 2017 Apr 3;214(4):1029-1047. PMID: 28330905 Colleluori G, Aguirre L, Dorin R, Robbins D, Blevins D, Barnouin Y, Chen R, Qualls C, Villareal DT, Armamento-Villareal R. Hypogonadal men with type 2 diabetes mellitus have smaller bone size and lower bone turnover. Bone. 2017 Jun;99:14-19. PMID: 28323146 Zhu L, Cheng J, Zhou B, Wei C, Yang W, Jiang D, Ijaz I, Tan X, Chen R, Fu J. Diagnosis for choroideremia in a large Chinese pedigree by next‑generation sequencing (NGS) and non‑invasive prenatal testing (NIPT). Mol Med Rep. 2017 Mar;15(3):1157-1164. PMID: 28098911 Eblimit A, Zaneveld SA, Liu W, Thomas K, Wang K, Li Y, Mardon G, Chen R. NMNAT1 E257K variant, associated with Leber Congenital Amaurosis (LCA9), causes a mild retinal degeneration phenotype. Exp Eye Res. 2018 Apr 17;173:32-43 Ge S, Xia X, Ding C, Zhen B, Zhou Q, Feng J, Yuan J, Chen R, Li Y, Ge Z, Ji J, Zhang L, Wang J, Li Z, Lai Y, Hu Y, Li Y, Li Y, Gao J, Chen L, Xu J, Zhang C, Jung SY, Choi JM, Jain A, Liu M, Song L, Liu W, Guo G, Gong T, Huang Y, Qiu Y, Huang W, Shi T, Zhu W, Wang Y, He F, Shen L, Qin J. A proteomic landscape of diffuse-type gastric cancer. Nat Commun. 2018 Mar 8;9(1):1012 Emerson CH, Lopez CR, Ribes-Zamora A, Polleys EJ, Williams CL, Yeo L, Zaneveld JE, Chen R, Bertuch AA. Ku DNA End-Binding Activity Promotes Repair Fidelity and Influences End-Processing During Nonhomologous End-Joining in Saccharomyces cerevisiae. Genetics. 2018 May;209(1):115-128. Imani S, Cheng J, Shasaltaneh MD, Wei C, Yang L, Fu S, Zou H, Khan MA, Zhang X, Chen H, Zhang D, Duan C, Lv H, Li Y, Chen R, Fu J. Genetic identification and molecular modeling characterization reveal a novel PROM1 mutation in Stargardt4-like macular dystrophy. Oncotarget. 2017 Nov 9;9(1):122-141. DuPont M, Jones EM, Xu M, Chen R. Investigating the disease association of USH2A p.C759F variant by leveraging large retinitis pigmentosa cohort data. Ophthalmic Genet. 2018 Apr;39(2):291-292. PMID: 29283788 Landrock KK, Sullivan P, Martini-Stoica H, Goldstein DS, Graham BH, Yamamoto S, Bellen HJ, Gibbs RA, Chen R, D'Amelio M, Stoica G. Pleiotropic neuropathological and biochemical alterations associated with Myo5a mutation in a rat Model. Brain Res. 2018 Jan 15;1679:155-170. PMID: 29217155 Imani S, Cheng J, Mobasher-Jannat A, Wei C, Fu S, Yang L, Jadidi K, Khosravi MH, Mohazzab-Torabi S, Shasaltaneh MD, Li Y, Chen R, Fu J. Identification of a novel RPGRIP1 mutation in an Iranian family with leber congenital amaurosis by exome sequencing. J Cell Mol Med. 2018 Mar;22(3):1733-1742 Porto FBO, Jones EM, Branch J, Soens ZT, Maia IM, Sena IFG, Sampaio SAM, Simões RT, Chen R. Molecular Screening of 43 Brazilian Families Diagnosed with Leber Congenital Amaurosis or Early-Onset Severe Retinal Dystrophy. Genes (Basel). 2017 Nov 29;8(12). Zhou Q, Yao F, Wang F, Li H, Chen R, Sui R. A heterozygous mutation in RPGR associated with X-linked retinitis pigmentosa in a patient with Turner syndrome mosaicism (45,X/46,XX). Am J Med Genet A. 2018 Jan;176(1):214-218 Eblimit A, Agrawal SA, Thomas K, Anastassov IA, Abulikemu T, Mardon G, Chen R. Conditional loss of Spata7 in photoreceptors causes progressive retinal degeneration in mice. Exp Eye Res. 2018 Jan;166:120-130. PMID: 29100828 Zaneveld SA, Eblimit A, Liang Q, Bertrand R, Wu N, Liu H, Nguyen Q, Zaneveld J, Wang K, Li Y, Chen R. Gene Therapy Rescues Retinal Degeneration in Reep6 Mutant Mice. Hum Gene Ther. 2018 Aug 13. doi: 10.1089/hum.2018.078. PMID: 30101608 PMCID: PMC6437630 Zhang L, Sun Z, Zhao P, Huang L, Xu M, Yang Y, Chen X, Lu F, Zhang X, Wang H, Zhang S, Liu W, Jiang Z, Ma S, Chen R, Zhao C, Yang Z, Sui R, Zhu X. Whole exome sequencing revealed HKDC1 as a candidate gene associated with autosomal-recessive retinitis pigmentosa. Hum Mol Genet. 2018 Jul 31. PMID: 30101608 Machol K, Jankovic J, Vijayakumar D, Burrage LC, Jain M, Lewis RA, Fuller GN, Xu M, Penas-Prado M, Gule-Monroe MK, Rosenfeld JA, Chen R, Eng CM, Yang Y, Lee BH, Moretti PM; Undiagnosed Diseases Network, Dhar SU. Atypical Alexander disease with dystonia, retinopathy, and a brain mass mimicking astrocytoma. Neurol Genet. 2018 Jul 20;4(4):e248. PMID: 30046660 Roman D, Zhong H, Yaklichkin S, Chen R, Mardon G. Conditional loss of Kcnj13 in the retinal pigment epithelium causes photoreceptor degeneration. Exp Eye Res. 2018 Jul 25;176:219-226 Li H, Jones EM, Li H, Yang L, Sun Z, Yuan Z, Chen R, Dong F, Sui R. Clinical and genetic features of eight Chinese autosomal-dominant optic atrophy pedigrees with six novel OPA1 pathogenic variants. Ophthalmic Genet. 2018 Jun 28:1-8. doi: 10.1080/13816810.2018.1466337. PMID: 29952689 Dharmat R, Eblimit A, Robichaux MA, Zhang Z, Nguyen TT, Jung SY, He F, Jain A, Li Y, Qin J, Overbeek P, Roepman R, Mardon G, Wensel TG, Chen R. SPATA7 maintains a novel photoreceptor-specific zone in the distal connecting cilium. J Cell Biol. 2018 Aug 6;217(8):2851-2865. doi: 10.1083/jcb.201712117. Epub 2018 Jun 13. PMID: 29899041 PMCID: PMC6080925 Wei C, Yang L, Cheng J, Imani S, Fu S, Lv H, Li Y, Chen R, Leung EL, Fu J. A novel homozygous variant of GPR98 causes usher syndrome type IIC in a consanguineous Chinese family by next generation sequencing. BMC Med Genet. 2018 Jun 11;19(1):99. PMID: 29890953 Yu B, Egbejimi A, Dharmat R, Xu P, Zhao Z, Long B, Miao H, Chen R, Wensel TG, Cai J, Chen Y. Phagocytosed photoreceptor outer segments activate mTORC1 in the retinal pigment epithelium. Sci Signal. 2018 May 29;11(532). PMID: 29844054 Jiewen Fu, Lu Ma, Jingliang Cheng, Lisha Yang, Chunli Wei, Shangyi Fu, Hongbin Lv, Rui Chen, Junjiang Fu A novel, homozygous nonsense variant of the CDHR1 gene in a Chinese family causes autosomal recessive retinal dystrophy by NGS‐based genetic diagnosis. Journal of Molecular and Cell Medicine 30 August 2018 https://doi.org/10.1111/jcmm.13841 Wang J, Zhao L, Wang X, Chen Y, Xu M, Soens ZT, Ge Z, Wang PR, Wang F, Chen R GRIPT: a novel case-control analysis method for Mendelian disease gene discovery. Genome Biol. 2018 Nov 26;19(1):203. doi: 10.1186/s13059-018-1579-x Huang J, Fu J, Fu S, Yang L, Nie K, Duan C, Cheng J, Li Y, Lv H, Chen R, Liu L, Fu J. Diagnostic value of a combination of next-generation sequencing, chorioretinal imaging and metabolic analysis: lessons from a consanguineous Chinese family with gyrate atrophy of the choroid and retina stemming from a novel OAT variant. Br J Ophthalmol. 2018 Oct 26. Yeung K, Wang F, Li Y, Wang K, Mardon G, Chen R Integrative genomic analysis reveals novel regulatory mechanisms of eyeless during Drosophila eye development. Nucleic Acids Res. 2018 Dec 14;46(22):11743-11758 Fu J, Ma L, Cheng J, Yang L, Wei C, Fu S, Lv H, Chen R, Fu J A novel, homozygous nonsense variant of the CDHR1 gene in a Chinese family causes autosomal recessive retinal dystrophy by NGS-based genetic diagnosis. J Cell Mol Med. 2018 Nov;22(11):5662-5669. 1997-2014 Rui Chen, Mehran Amoui, Zhihuan Zhang, and Graeme Mardon (1997) Dachshund and Eyes Absent Proteins Form a Complex and Function Synergistically to Induce Ectopic Eye Development in Drosophila. Cell 91(7): 893-903. PMID:9428513, Impact factor: 28.710 Rui Chen, Halder G, Zhang Z, Mardon G (1999) Signaling by the TGF-β homolog decapentaplegic functions reiteratively within the network of genes controlling retinal cell fate determination in Drosophila. Development 126(5):935-43. PMID:9927595. Impact factor: 6.059 Wei-Wen Cai, Rui Chen, Richard A. Gibbs, and Allan Bradley (2001) A Clone-Array Pooled Shotgun Strategy for Sequencing Large Genomes. Genome Research 11:1619-1623 PMID:11591638, Impact factor:11.351 Rui Chen, John B. Bouck, George M. Weinstock, and Richard A. Gibbs (2001) Comparing Vertebrate Whole-Genome Shotgun Reads to the Human Genome. Genome Research 11:1807-1816 PMID:11691844, Impact factor:11.351 Kartik S. Pappu, Rui Chen, Brooke W. Middlebrooks, Catherine Woo, Ulrike Heberlein, and Graeme Mardon (2003) Mechanism of hedgehog Signaling During Drosophila Eye Development. Development 130: 3053-3062 PMID:12756186 Impact factor:6.059 Rat Genome Consortium (2004) Genome Sequence of the Brown Norway Rat Yields Insights into Mammalian Evolution. Nature 428:493-521 PMID:15057822, Impact factor:38.138 Paul Havlak, Rui Chen (co first author), K. James Durbin, Amy Egan, Yanru Ren, Xing-Zhi Song, George M. Weinstock, and Richard Gibbs (2004) The Atlas Genome Assembly System. Genome Research 14:721-732 PMID:15060016, PMCID:PMC383319, Impact factor:11.351 Rui Chen, Erica Sodergren, George M. Weinstock, and Richard Gibbs (2004) Dynamic Building of a BAC Clone Tiling Path for the Rat Genome Sequencing Project. Genome Research 14: 679-684 PMID:15060010, PMCID:PMC383313, Impact factor:11.351 Drosophila pseudoobscura Genome Consortium (2005) Comparative genome sequencing of Drosophila pseudoobscura : Chromosomal, gene and cis-element evolution. Genome Research 15: 1-18. PMID:15632085, PMCID:PMC540289, Impact factor:11.351 Mark T. Ross, et. al., Rui Chen, et al., Jane Rogers & David R. Bentley (2005) The DNA sequence of the human X chromosome Nature 434, 325 – 337 PMID:15772651, PMCID:PMC2665286, Impact factor:38.138 Pappu KS, Ostrin EJ, Middlebrooks BW, Sili BT, Chen R, Atkins MR, Gibbs R, Mardon G (2005) Dual regulation and redundant function of two eye-specific enhancers of the Drosophila retinal determination gene dachshund. Development; 132(12):2895-905. PMID:15930118, Impact factor:6.059 Steven E. Scherer, Donna M. Muzny, Christian J. Buhay, Rui Chen, et al (2006) The finished DNA sequence of human chromosome 12. Nature 440, 346-351 PMID:16541075, Impact factor:38.138 Edwin J. Ostrin, Yumei Li, Kristi Hoffman, Jing Liu, Keqing Wang, Li Zhang, Graeme Mardon, and Rui Chen (2006) Genome-Wide Identification of Direct Targets of the Drosophila Retinal Determination Protein Eyeless. Genome Research 16: 466-476. PMID:16533912, PMCID:PMC1457028, Impact factor:11.351 HGSC (2006) The DNA sequence, annotation and analysis of human chromosome 3. Nature. 440(7088):1194-8. PMID:16641997, Impact factor:38.138 HGSC (2007) Evolutionary and biomedical insights from the rhesus macaque genome. Science 316(5822):222-34. PMID:17431167, Impact factor:34.661 Riccardo Papa, Clayton M Morrison, James R Walters, Brian A Counterman, Rui Chen, Georg Halder, Laura Ferguson, Nicola Chamberlain, Richard ffrench-Constant, Durrell D Kapan, Chris D Jiggins, Robert D Reed and William O McMillan (2008) Highly conserved gene order and numerous novel repetitive elements in genomic regions linked to wing pattern variation in Heliconius butterflies. BMC Genomics, 9: 345 PMID:18647405, PMCID:PMC2515155, Impact factor:3.867 Anjana Srivatsan, Yi Han, Jianlan Peng, Ashley Tehranchi, Richard Gibbs, Jue Wang, and Rui Chen (2008) High Precision Whole-Genome Sequencing of Laboratory Strains Facilitates Genetic Studies. PLOS Genetics, 4(8) e1000139. PMID:18670626, , PMCID:PMC2474695, Impact factor:7.528 Yumei Li, Hui Wang, Richard A. Gibbs, Richard Alan Lewis, James R. Lupski, Graeme Mardon, and Rui Chen (2009) Mutation Survey of Known LCA Genes and Loci in the Saudi Arabian Population. IOVS, 50(3): 1336-1343 PMID:18936139, PMCID:PMC2695987, Impact factor:3.427 Hui Wang, Anneke I den Hollander, Yalda Moayedi, Abuduaini Abulimiti, Yumei Li, Rob WJ Collin, Carel B Hoyng, Irma Lopez, Molly Bray, Richard Alan Lewis, James R. Lupski, Graeme Mardon, Robert K Koenekoop, and Rui Chen (2009) Mutations in SPATA7 cause Leber congenital amaurosis and juvenile retinitis pigmentosa. American Journal of Human Genetics, 84: 380-387 PMID: 19268277, PMCID:PMC2668010, Impact factor:11.202 Bryce Daines, Hui Wang, Yumei Li, Yi Han, Richard Gibbs, and Rui Chen (2009) High-throughput Multiplex Sequencing to Discover Copy Number Variants in Drosophila. 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Ting MAJ, Topilow NJ, Ediriwickrema LS, Yoon JS, Liu CY, Korn BS, Kikkawa DO. A comparison of proptosis reduction with teprotumumab versus surgical decompression based on fat-to-muscle ratio in thyroid eye disease. Orbit. 2024 Apr;43(2):222-230. doi: 10.1080/01676830.2023.2282509. Epub 2023 Nov 17. Dallalzadeh LO, Ediriwickrema LS, Fung SE, Men CJ, Kossler AL, Kupcha AC, Mawn LA, Burkat CN, van Landingham SW, Conger JR, Simmons B, Pham C, Akella SS, Setabutr P, Ho T, Couch SM, Kim JS, Demirci H, Korn BS, Kikkawa DO, Liu CY. Transcutaneous retrobulbar amphotericin B for rhino-orbital-cerebral mucormycosis: a multi-center retrospective comparative study. Orbit. 2024 Feb;43(1):41-48. LaRocca MC, Dermarkarian CR, Ediriwickrema LS, Tao JP. Staphylococcus pseudintermedius of a semicircular facial flap with concomitant COVID-19 infection. Can J Ophthalmol. 2023 Apr 6:S0008-4182(23)00104-7. Dallalzadeh LO, Ediriwickrema LS, Fung SE, et al. Transcutaneous retrobulbar amphotericin B for rhino- orbital-cerebral mucormycosis: a multi-center retrospective comparative study. Orbit. 2023 Mar 7:1-8. Roland LT, Humphreys IM, Le CH, Babik JM, et al. Diagnosis, Prognosticators, and Management of Acute Invasive Fungal Rhinosinusitis: Multidisciplinary Consensus Statement and Evidence-Based Review with Recommendations. Int Forum Allergy Rhinol. 2023 Sep;13(9):1615-1714. Nair AA, Ediriwickrema LS, Dolman PJ, Law G, Harrison AR, Mokhtarzadeh A, Stewart K, Men C, Lucarelli MJ, van Landingham S, Wingelaar M, Verma R, Chen A,Selva D, Garrity J, Eckel L, Kazim M, Godfrey K, Baxter SL, Korn BS, Kikkawa DO.Predictive Modeling of New-Onset Postoperative Diplopia Following Orbital Decompression for Thyroid Eye Disease. Ophthalmic Plast Reconstr Surg. 2022 May 13. doi: 10.1097/IOP.0000000000002196. Epub ahead of print. PMID: 35551414. Himstead AS, Gustafson KM, Hasso AN, Ediriwickrema LS. Internal Carotid Artery Pseudoaneurysm Causing an Abducens Nerve Palsy: A Case Report. J Neuroophthalmol. 2021 Aug 18. doi: 10.1097/WNO.0000000000001387. Epub ahead of print. PMID: 35503976. Pai A, Carter S, Ediriwickrema LS. Bilateral Disc Edema Masquerade. JAMA Ophthalmol. 2021 Oct 1;139(10):1137-1138. doi: 10.1001/jamaophthalmol.2021.0096. PMID: 34351380. Chen AJ, Ediriwickrema LS, Verma R, Vavinskaya V, Shaftel S, Deconde AS, Korn BS, Kikkawa DO, Liu CY. A case of mistaken identity: Saksenaea vasiformis of the orbit. Orbit. 2021 Dec;40(6):521-524. doi: 10.1080/01676830.2020.1814354. Epub 2020 Aug 30. PMID: 32862746. Long CP, Lu T, Ediriwickrema LS, Lin JH, Korn BS, Kikkawa DO, Liu CY. Colorectal carcinoma presenting in the orbit: mass effect from an uncommon cause. Orbit. 2021 Aug;40(4):338-341. doi: 10.1080/01676830.2020.1787466. Epub 2020 Jul 9. PMID: 32643502. Men CJ, Ko AC, Ediriwickrema LS, Liu CY, Kikkawa DO, Korn BS. Canalicular laceration repair using a self-retaining, bicanalicular, hydrophilic nasolacrimal stent. Orbit. 2021 Jun;40(3):239-242. doi: 10.1080/01676830.2020.1768559. Epub 2020 May 20. PMID: 32431204. Yarmohammadi A, Baxter SL, Ediriwickrema LS, Williams EC, Kobayashi LM, Liu CY, Korn BS, Kikkawa DO. Characterization of Facial Trauma Associated with Standing Electric Scooter Injuries. Ophthalmology. 2020 Jul;127(7):988-990. doi: 10.1016/j.ophtha.2020.02.007. Epub 2020 Feb 14. PMID: 32359837; PMCID: PMC7703691. Long CP, Ediriwickrema LS, Liu CY. Severe Progressive Bilateral Vision Loss With Headaches. JAMA Ophthalmol. 2020 May 1;138(5):582-583. doi: 10.1001/jamaophthalmol.2020.0362. PMID: 32191266. Toomey CB, Protopsaltis NJ, Phou S, Bakhoum MF, Thorson JA, Ediriwickrema LS, Korn BS, Kikkawa DO, Goldbaum MH, Lin JH. PREVALENCE OF MISMATCH REPAIR GENE MUTATIONS IN UVEAL MELANOMA. Retina. 2020 Nov;40(11):2216-2220. doi: 10.1097/IAE.0000000000002732. PMID: 32032254. Men CJ, Ediriwickrema LS, Paik JS, Murdock J, Yen MT, Ng JD, Liu CY, Korn BS, Kikkawa DO. Surgical Intervention of Periocular Infantile Hemangiomas in the Era of β-Blockers. Ophthalmic Plast Reconstr Surg. 2020 Jan/Feb;36(1):70-73. doi: 10.1097/IOP.0000000000001466. PMID: 31809485. Prendes MA, Geng J, Ediriwickrema LS, Areephanthu C, Burchell P, Kikkawa DO, Nunery WR, Korn B, Harold Lee HB. Assessment of the Safety and Efficacy of Prolapsed Orbital Fat Resection During Involutional Entropion Repair. Ophthalmic Plast Reconstr Surg. 2020 Jan/Feb;36(1):34-37. doi: 10.1097/IOP.0000000000001452. PMID: 31567912. Ediriwickrema LS, Liu CY, Kikkawa DO, Korn BS. Development of Poliosis Following Checkpoint Inhibitor Treatment for Cutaneous Melanoma. Ophthalmic Plast Reconstr Surg. 2019 Sep/Oct;35(5):e121-e122. doi: 10.1097/IOP.0000000000001451. PMID: 31373986. Chen TH, Yang PT, Kikkawa DO, Ediriwickrema LS, Afshari NA, Lee JE, Korn BS. A modified technique for bedside amniotic membrane application to the eyelid margins for Stevens-Johnson syndrome. Can J Ophthalmol. 2019 Jun;54(3):e118-e120. doi: 10.1016/j.jcjo.2018.08.020. Epub 2018 Nov 28. PMID: 31109496. Moysidis SN, Koulisis N, Rodger DC, Chao JR, Leng T, de Carlo T, Burkemper B, Ediriwickrema LS, George MS, Jiang Y, Bohm KJ, Gulati S, Torres RJ, Meallet MA, Moshfeghi AA, Flynn HW Jr, Mieler WF, Williams GA, Humayun MS, Eliott D. Thomas A. Swift's Electric Rifle Injuries to the Eye and Ocular Adnexa: The Management of Complex Trauma. Ophthalmol Retina. 2019 Mar;3(3):258-269. doi: 10.1016/j.oret.2018.10.005. Epub 2018 Oct 10. PMID: 31014704. Ediriwickrema LS, Geng J, Nair AA, Prendes M, Gerber AL, Yang PT, Liu CY, Nunery WR, Harold Lee HB, Kikkawa DO, Korn BS. Single Suture Müeller Muscle Conjunctival Resection (ssMMCR): A Modified Technique for Ptosis Repair. Ophthalmic Plast Reconstr Surg. 2019 Jul/Aug;35(4):403-406. doi: 10.1097/IOP.0000000000001380. PMID: 30908466. Ediriwickrema LS, Korn BS, Kikkawa DO. Thyroid-Related Orbitopathy, Restrictive Strabismus, Dermopathy, and Acropachy. JAMA Ophthalmol. 2018 Dec 1;136(12):e183217. doi: 10.1001/jamaophthalmol.2018.3217. Epub 2018 Dec 13. PMID: 30543354. Ediriwickrema LS, Korn BS, Kikkawa DO. Orbital Decompression for Thyroid-Related Orbitopathy During the Quiescent Phase. Ophthalmic Plast Reconstr Surg. 2018 Jul/Aug;34(4S Suppl 1):S90-S97. doi: 10.1097/IOP.0000000000001119. PMID: 29771754. Ediriwickrema LS, Miller NR. Tumors of the Optic Nerve and its Sheath. Int Ophthalmol Clin. 2018 Spring;58(2):237-260. doi: 10.1097/IIO.0000000000000216. PMID: 29517652. Stroh IG, Ediriwickrema LS, Miller NR. Gorham-Stout Disease Presenting as Acute Unilateral Proptosis. J Neuroophthalmol. 2018 Mar;38(1):70-74. doi: 10.1097/WNO.0000000000000569. PMID: 28837441. Liu TYA, Ediriwickrema LS, Vizcaino MA, Wenick A, Miller NR. Optic Nerve Infiltration and Vitreous Seeding by a Cerebral Glioblastoma. JAMA Ophthalmol. 2017 Apr 1;135(4):400-401. doi: 10.1001/jamaophthalmol.2016.5835. PMID: 28208187. Ediriwickrema LS, Chhadva P, Rodger DC, Ameri H, Rao NA. INTRAVENOUS IMMUNOGLOBULIN IN THE TREATMENT OF JUVENILE RETINITIS PIGMENTOSA-ASSOCIATED CYSTOID MACULAR EDEMA AND UVEITIS. Retin Cases Brief Rep. 2018 Summer;12(3):242-246. doi: 10.1097/ICB.0000000000000478. PMID: 27828903. Ediriwickrema LS, Burnstine M, Saber MS, Rao N. Malignant solitary fibrous tumor of the orbit: Spectrum of histologic features. Am J Ophthalmol Case Rep. 2016 Oct 28;5:7-10. doi: 10.1016/j.ajoc.2016.10.007. PMID: 29503937; PMCID: PMC5757752. Zhu D, Berry JL, Ediriwickrema L, Wong K, Lee TC, Murphree AL, Kim JW, Jubran R. Long-Term Outcomes of Group B Eyes in Patients with Retinoblastoma Treated with Short-Course Chemoreduction: Experience from Children's Hospital Los Angeles/University of Southern California. Ocul Oncol Pathol. 2015 Dec;2(2):105-11. doi: 10.1159/000439593. Epub 2015 Nov 5. PMID: 27172535; PMCID: PMC4847672. Samimi DB, Ediriwickrema LS, Bielory BP, Miller D, Lee W, Johnson TE. Microbiology and Biofilm Trends of Silicone Lacrimal Implants: Comparing Infected Versus Routinely Removed Stents. Ophthalmic Plast Reconstr Surg. 2016 Nov/Dec;32(6):452-457. doi: 10.1097/IOP.0000000000000590. PMID: 26588208. Ediriwickrema LS, Francis JH, Arslan-Carlon V, Dalecki PH, Brodie SE, Marr BP, Abramson DH. Intravenous injection of indocyanine green results in an artificial transient desaturation by pulse oximetry. Retin Cases Brief Rep. 2015 Summer;9(3):252-5. doi: 10.1097/ICB.0000000000000152. PMID: 26002141. Ediriwickrema LS, Zaheer W. Diffuse large cell lymphoma presenting as a sacral mass and lupus anticoagulant. Yale J Biol Med. 2011 Dec;84(4):433-8. PMID: 22180680; PMCID: PMC3238310. Polgar O, Ediriwickrema LS, Robey RW, Sharma A, Hegde RS, Li Y, Xia D, Ward Y, Dean M, Ozvegy-Laczka C, Sarkadi B, Bates SE. Arginine 383 is a crucial residue in ABCG2 biogenesis. Biochim Biophys Acta. 2009 Jul;1788(7):1434-43. doi: 10.1016/j.bbamem.2009.04.016. Epub 2009 May 3. PMID: 19406100; PMCID: PMC4163909. Polgar O, Deeken JF, Ediriwickrema LS, Tamaki A, Steinberg SM, Robey RW, Bates SE. The 315-316 deletion determines the BXP-21 antibody epitope but has no effect on the function of wild type ABCG2 or the Q141K variant. Mol Cell Biochem. 2009 Feb;322(1-2):63-71. doi: 10.1007/s11010-008-9940-0. Epub 2008 Nov 11. PMID: 19002564; PMCID: PMC2631614. Vladimir Kefalov, PhD 2023-2024 Gao F., Tom E., Rydz C., Cho W., Kolesnikov A.V., Sha Y., Papadam A., Jafari S., Joseph A., Ahanchi A., Saraei N.B.S., Lyon D., Foik A., Nie Q., Grassmann F., Kefalov V.J., Skowronska-Krawczyk D. (2024) Polyunsaturated Fatty Acid - mediated Cellular Rejuvenation for Reversing Age-related Vision Decline. bioRxiv [Preprint]. doi: 10.1101/2024.07.01.601592. E. Zander, Kefalov V.J. (2025) Retinal cell types: Rod and cone photoreceptors. Handbook of Clinical Neurobiology – Retina. In press. Avilés E.C., Wang S.K., Patel S., Shi S., Lin L., Kefalov V.J., Goodrich L.V., Cepko C.L., Xue Y. (2025) ERG responses to high-frequency flickers require FAT3 signaling in mouse retinal bipolar cells. J Gen Physiol 157(2): e202413642. doi: 10.1085/jgp.202413642. Volkov L.I., Ogawa Y., Somjee R., Vedder H.E., Powell H.E., Poria D., Meiselman S., Kefalov V.J., Corbo J.C. (2024) Samd7 represses short-wavelength cone genes to preserve long-wavelength cone and rod photoreceptor identity. Proc Natl Acad Sci U S A. 121(47):e2402121121. doi: 10.1073/pnas.2402121121. Leinonen H., Zhang J., Occelli L.M., Seemab U., Choi E.H., L P Marinho L.F., Querubin J., Kolesnikov A.V., Galinska A., Kordecka K., Hoang T., Lewandowski D., Lee T.T., Einstein E.E., Einstein D.E., Dong Z., Kiser P.D., Blackshaw S., Kefalov V.J., Tabaka M., Foik A., Petersen-Jones S.M., Palczewski K. (2024) A combination treatment based on drug repurposing demonstrates mutation-agnostic efficacy in pre-clinical retinopathy models. Nat Commun. 2024 Jul 15;15(1):5943. doi: 10.1038/s41467-024-50033-5. Bassetto M., Kolesnikov A.V., Lewandowski D., Kiser J.Z., Halabi M., Einstein D.E., Choi E.H., Palczewski K., Kefalov V.J., Kiser P.D. (2024) Dominant role for pigment epithelial CRALBP in supplying visual chromophore to photoreceptors. Cell Rep. 2024 May 28;43(5):114143. doi: 10.1016/j.celrep.2024.114143. Sato S., Kefalov V.J. (2024) The Retina-Based Visual Cycle. Annu Rev Vis Sci. 2024 May 9. doi: 10.1146/annurev-vision-100820-083937. Online ahead of print. Kolesnikov A.V., Murphy D.P., Corbo J.C., Kefalov V.J. (2024) Germline knockout of Nr2e3 protects photoreceptors in three distinct mouse models of retinal degeneration. Proc Natl Acad Sci U S A. 2024 Mar 12;121(11):e2316118121. doi: 10.1073/pnas.2316118121. Epub 2024 Mar 5 Rose K., Chen N., Andreev A., Chen J., Kefalov V.J., Chen J. (2024) Light regulation of rhodopsin distribution during outer segment renewal in murine rod photoreceptors. Curr Biol. 2024 Mar 11. pii: S0960-9822(24)00252-5. doi: 10.1016/j.cub.2024.02.070. [Epub ahead of print] Tworak A., Kolesnikov A.V., Hong J.D., Choi E.H., Luu J.C., Palczewska G., Dong Z., Lewandowski D., Brooks M.J., Campello L., Swaroop A., Kiser P.D., Kefalov V.J., Palczewski K. (2023) Rapid RGR-dependent visual pigment recycling is mediated by the RPE and specialized Müller glia. Cell Rep. 42(8):112982. doi: 10.1016/j.celrep.2023.112982. Online ahead of print. Moakedi F., Aljammal R., Poria D., Saravanan T., Rhodes S.B., Reid C., Guan T., Kefalov V.J., Ramamurthy V. (2023) Prenylation is essential for the enrichment of cone phosphodiesterase-6 (PDE6) in outer segments and efficient cone phototransduction. Hum Mol Genet. ddad108. doi: 10.1093/hmg/ddad108. Online ahead of print. Xue Y., Sun X., Wang S.K., Collin G.B., Kefalov V.J., Cepko C.L. (2023) Chromophore supply modulates cone function and survival in retinitis pigmentosa mouse models. Proc Natl Acad Sci U S A. 120:e2217885120. doi: 10.1073/pnas.2217885120. Poria D., Kolesnikov A.V., Lee T.J., Salom D., Palczewski K., Kefalov V.J. (2023) Investigating the Role of Rhodopsin F45L Mutation in Mouse Rod Photoreceptor Signaling and Survival. eNeuro. 0330-22.2023. doi: 10.1523/ENEURO.0330-22.2023. 2016-2022 Kolesnikov A.V., Lobysheva E., Gnana-Prakasam J.P., Kefalov V.J., Kisselev O.G. (2022) Regulation of rod photoreceptor function by farnesylated G-protein γ-subunits. PLoS One 17:e0272506. Kolesnikov A.V., Luu J., Jin H., Palczewski K., Kefalov V.J. (2022) Deletion of Protein Phosphatase 2A Accelerates Retinal Degeneration in GRK1- and Arr1-Deficient Mice. Invest Ophthalmol Vis Sci. 63:18. Widjaja-Adhi M.A.K., Kolesnikov A.V., Vasudevan S., Park P.S., Kefalov V.J., Golczak M. (2022) Acyl-CoA:wax alcohol acyltransferase 2 modulates the cone visual cycle in mouse retina. FASEB J. 36(7):e22390. Lankford C.K., Umino Y., Poria D., Kefalov V.J., Solessio E., Baker S.A. (2022) Cone-driven retinal responses are shaped by rod but not cone HCN1. J Neurosci. 42:4231-4249. Poria D, Sun C, Santeford A, Kielar M, Apte R.S., Kisselev O.G., Chen S., Kefalov V.J. (2022) EML1 is essential for retinal photoreceptor migration and survival. Sci Rep. [in press]. Inamdar S.M., Lankford C.K., Poria D., Laird J.G., Solessio E., Kefalov V.J., Baker S.A. (2021) Differential impact of Kv8.2 loss on rod and cone signaling and degeneration. Hum Mol Genet. doi: 10.1093/hmg/ddab301. [in press]. Laradji A., Karakocak B.B., Kolesnikov A.V., Kefalov V.J., Ravi N. (2021) Hyaluronic acid-based Gold Nanoparticles for the Topical De-livery of Therapeutics to the Retina and the Retinal Pigment Epithelium. Polymers [in press]. Kefalov V.J., Genovese F., Reisert J. (2021) Sensory transduction in photoreceptors and olfactory sensory neurons: common features and distinct characteristics. Front Cell Neurosci | doi: 10.3389/fncel.2021.761416. Laradji A.M., Kolesnikov A.V., Karakoçak B.B., Kefalov V.J., Ravi N. (2021) Redox-Responsive Hyaluronic Acid-Based Nanogels for the Topical Delivery of the Visual Chromophore to Retinal Photoreceptors. ACS Omega. 6:6172-6184. Kolesnikov A.V., Kiser P.D., Palczewski K., Kefalov V.J. (2021) Function of mammalian M-cones depends on the level of CRALBP in Müller cells. J Gen Physiol. 153:e202012675. Bisbach C.M., Hutto R.A., Poria D., Cleghorn W.M., Abbas F., Vinberg F., Kefalov V.J., Hurley J.B., Brockerhoff S.E. (2020) Mitochondrial Calcium Uniporter (MCU) deficiency reveals an alternate path for Ca2+ uptake in photoreceptor mitochondria. Sci Rep. 10:16041. doi: 10.1038/s41598-020-72708-x. Volkov L.I., Kim-Han J., Saunders L., Poria D., Hughes A.E.O., Kefalov V.J., Parichy D.M., Corbo J.C. (2020) Thyroid hormone receptors mediate two distinct mechanisms of long-wavelength vision. Proc Natl Acad Sci U S A. 117:15262-15269. Xue Y., Razafsky D., Hodizc D., Kefalov V.J. (2020) Mislocalization of cone nuclei impairs cone function in mice. FASEB J. 34:10242-10249. Thebeau C., Zhang S., Kolesnikov A.V., Kefalov V.J., Semenkovich C.F., Rajagopal R. (2020) Light deprivation reduces the severity of experimental diabetic retinopathy. Neurobiol Dis. 137:104754. Kolesnikov A.V., Chrispell, J.D., Osawa S., Kefalov V.J. #, Weiss E.R. # (2020) Phosphorylation at Serine 21 in G protein-coupled receptor kinase 1 (GRK1) is required for normal kinetics of dark adaption in rod but not cone photoreceptors. FASEB J. 34:2677-2690 Ruminski D., Palczewska G., Nowakowski M., Zielińska A., Kefalov V.J., Komar K., Palczewski K., Wojtkowski M. (2019) Two-photon microperimetry: sensitivity of human photoreceptors to infrared light. Biomed Opt Express. 10:4551-4567. Vinberg F., Palczewska G., Zhang J., Komar K., Wojtkowski M., Kefalov V.J., Palczewski K. (2019) Sensitivity of Mammalian Cone Photoreceptors to Infrared Light. Neuroscience 416:100-108. Gospe S.M., Travis A.M., Kolesnikov A.V., Klingeborn M., Wang L., Kefalov V.J., Arshavsky V.Y. (2019) Photoreceptors in a Mouse Model of Leigh Syndrome are Capable of Normal Light-Evoked Signaling. J Biol Chem 294:12432-12443. Leinonen H., Choi E.H., Gardella A., Kefalov V.J., Palczewski K., (2019) A mixture of FDA-approved monoaminergic drugs protects the retina from light-damage in diverse models of night blindness. Invest Ophthalmol Vis Sci 60:1442-1453. Kiser P.D., Kolesnikov A.V., Kiser J.Z., Dong Z., Chaurasia B., Wang L., Summers S.A., Hoang T., Blackshaw S., Peachey N.S., Kefalov V.J., Palczewski K. (2019) Conditional deletion of Des1 in the mouse retina does not impair the visual cycle in cones. FASEB J. 33:5782-5792. Sato S., Jastrzebska B., Engel A., Palczewski K., Kefalov V.J. (2019) Apo-opsin exists in equilibrium between a predominant inactive and a rare highly active state. J Neurosci. 39:212-223. Vinberg F., Kefalov V.J. (2018) Investigating the Ca2+-dependent and Ca2+-independent mechanisms for mammalian cone light adaptation. Sci Rep. 8:15864. doi: 10.1038/s41598-018-34073-8. Kolesnikov A.V., Tang P.H., Kefalov V.J. (2018) Examining the Role of Cone-expressed RPE65 in Mouse Cone Function. Sci Rep. 8:14201. doi: 10.1038/s41598-018-32667-w. Vinberg F., Chen J., Kefalov V.J. (2018) Regulation of calcium homeostasis in the outer segments of rod and cone photoreceptors. Prog Retin Eye Res 67:87-101. Vinberg F., Peshenko I.V., Chen J., Dizhoor A.M., Kefalov V.J. (2018) Guanylate cyclase-activating protein 2 contributes to phototransduction and light adaptation in mouse cone photoreceptors. J Biol Chem. 293:7457-7465. Sarria I., Cao Y., Wang Y., Ingram, N.T., Orlandi C., Kamasawa N., Kolesnikov A.V., Kefalov, V.J., Sampath, A.P., Martemyanov, K. (2018) LRIT1 modulates adaptive changes in synaptic communication of cone photoreceptors. Cell Reports 22:3562-3573. Sato S., Peshenko I.V., Olshevskaya E.V., Kefalov V.J.#, Dizhoor A.M.# (2018) GUCY2D Cone-Rod Dystrophy-6 is a 'Phototransduction Disease' Triggered by Abnormal Calcium Feedback on Retinal Membrane Guanylyl Cyclase 1. J Neurosci. 38:2990-3000. Kiser P.D., Zhang J., Sharma A., Angueyra J.M., Kolesnikov A.V., Badiee M., Tochtrop G.P., Kinoshita J., Peachey N.S., Li W., Kefalov V.J.#, Palczewski K.# (2018) Retinoid isomerase inhibitors impair but do not block mammalian cone photoreceptor function. J Gen Physiol. 150:571-590. Kolesnikov A.V., Orban T., Jin H., Brooks C., Hofmann L., Dong Z., Sokolov M., Palczewski K.#, Kefalov V.J.# (2017) Dephosphorylation by protein phosphatase 2A regulates visual pigment regeneration and the dark adaptation of mammalian photoreceptors. Proc Natl Acad Sci U S A. 114:E9675-E9684. 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Sander CL, Luu J, Kim K, Furkert D, Jang K, Reichenwallner J, Kang M, Lee HJ, Eger BT, Choe HW, Fiedler D, Ernst OP, Kim YJ, Palczewski K, Kiser PD. Structural evidence for visual arrestin priming via complexation of phosphoinositols. Structure. 2022;30(2):263-77 e5. Epub 20211021. doi: 10.1016/j.str.2021.10.002. PubMed PMID: 34678158; PMCID: PMC8818024. Daruwalla A, Sui X, Kiser PD. Preparation of carotenoid cleavage dioxygenases for X-ray crystallography. Methods Enzymol. 2022;671:243-71. Epub 20211122. doi: 10.1016/bs.mie.2021.10.020. Kiser PD. Retinal Pigment Epithelium 65 kDa Protein (RPE65): An Update. Prog Retin Eye Res. 2021:101013. Epub 2021/10/05. doi: 10.1016/j.preteyeres.2021.101013. PubMed PMID: 34607013. Occelli LM, Daruwalla A, De Silva SR, Winkler PA, Sun K, Pasmanter N, Minella A, Querubin J, Lyons LA, Consortium L, Robson AG, Heon E, Michaelides M, Webster AR, Palczewski K, Vincent A, Mahroo OA, Kiser PD, Petersen-Jones SM. A large animal model of RDH5-associated retinopathy recapitulates important features of the human phenotype. Hum Mol Genet. 2021. Epub 2021/11/03. doi: 10.1093/hmg/ddab316. PubMed PMID: 34726233. Choi EH, Suh S, Einstein DE, Leinonen H, Dong Z, Rao SR, Fliesler SJ, Blackshaw S, Yu M, Peachey NS, Palczewski K, Kiser PD. An inducible Cre mouse for studying roles of the RPE in retinal physiology and disease. JCI Insight. 2021;6(9). Epub 2021/03/31. doi: 10.1172/jci.insight.146604. PubMed PMID: 33784255. York NJ, Lockart MM, Sardar S, Khadka N, Shi W, Stenkamp RE, Zhang J, Kiser PD, Pierce BS. Structure of 3-mercaptopropionic acid dioxygenase with a substrate analog reveals bidentate substrate binding at the iron center. J Biol Chem. 2021:100492. Epub 2021/03/05. doi: 10.1016/j.jbc.2021.100492. PubMed PMID: 33662397; PMCID: PMC8050391. Kiser PD, Palczewski K. Pathways and disease-causing alterations in visual chromophore production for vertebrate vision. J Biol Chem. 2021;296:100072. Epub 2020/11/15. doi: 10.1074/jbc.REV120.014405. PubMed PMID: 33187985; PMCID: PMC7948990. Kolesnikov AV, Kiser PD, Palczewski K, Kefalov VJ. Function of mammalian M-cones depends on the level of CRALBP in Muller cells. J Gen Physiol. 2021;153(1). Epub 2020/11/21. doi: 10.1085/jgp.202012675. PubMed PMID: 33216847; PMCID: PMC7685772. Bandara S, Thomas LD, Ramkumar S, Khadka N, Kiser PD, Golczak M, von Lintig J. The Structural and Biochemical Basis of Apocarotenoid Processing by beta-Carotene Oxygenase-2. ACS Chem Biol. 2021;16(3):480-90. Epub 2021/02/19. doi: 10.1021/acschembio.0c00832. PubMed PMID: 33600157; PMCID: PMC8082539. Suh S, Choi EH, Leinonen H, Foik AT, Newby GA, Yeh WH, Dong Z, Kiser PD, Lyon DC, Liu DR, Palczewski K. Restoration of visual function in adult mice with an inherited retinal disease via adenine base editing. Nat Biomed Eng. 2021;5(2):169-78. Epub 2020/10/21. doi: 10.1038/s41551-020-00632-6. PubMed PMID: 33077938; PMCID: PMC7885272. Sander CL, Sears AE, Pinto AFM, Choi EH, Kahremany S, Gao F, Salom D, Jin H, Pardon E, Suh S, Dong Z, Steyaert J, Saghatelian A, Skowronska-Krawczyk D, Kiser PD, Palczewski K. Nano-scale resolution of native retinal rod disk membranes reveals differences in lipid composition. J Cell Biol. 2021;220(8). Epub 2021/06/17. doi: 10.1083/jcb.202101063. PubMed PMID: 34132745; PMCID: PMC8240855. Blum E, Zhang J, Zaluski J, Einstein DE, Korshin E, Kubas A, Gruzman A, Tochtrop GP, Kiser PD, Palczewski K. Rational alteration of pharmacokinetics of chiral fluorinated and deuterated derivatives of emixustat for retina therapies. J Med Chem. 2021;64(12):8287-302. Thomas LD, Bandara S, Parmar VM, Srinivasagan R, Khadka N, Golczak M, Kiser PD, von Lintig J. The human mitochondrial enzyme BCO2 exhibits catalytic activity toward carotenoids and apocarotenoids. J Biol Chem. 2020;295(46):15553-65. Epub 2020/09/03. doi: 10.1074/jbc.RA120.015515. PubMed PMID: 32873706. Kakodkar P, More S, Andras K, Papakonstantinou N, Kelly S, Makrooni MA, Ortutay C, Szegezdi E. Aspartic Aminopeptidase Is a Novel Biomarker of Aggressive Chronic Lymphocytic Leukemia. Cancers (Basel). 2020;12(7). Epub 2020/07/16. doi: 10.3390/cancers12071876. PubMed PMID: 32664705; PMCID: PMC7408864. Gazda MA, Toomey MB, Araujo PM, Lopes RJ, Afonso S, Myers CA, Serres K, Kiser PD, Hill GE, Corbo JC, Carneiro M. Genetic Basis of De Novo Appearance of Carotenoid Ornamentation in Bare-Parts of Canaries. Mol Biol Evol. 2020;37(5):1317-28. Epub 2020/01/14. doi: 10.1093/molbev/msaa006. PubMed PMID: 31930402. Sears AE, Albiez S, Gulati S, Wang B, Kiser P, Kovacik L, Engel A, Stahlberg H, Palczewski K. Single particle cryo-EM of the complex between interphotoreceptor retinoid-binding protein and a monoclonal antibody. FASEB J. 2020;34(10):13918-34. Epub 2020/08/30. doi: 10.1096/fj.202000796RR. PubMed PMID: 32860273; PMCID: PMC7589273. Palczewski K, Kiser PD. Shedding new light on the generation of the visual chromophore. Proc Natl Acad Sci U S A. 2020;117(33):19629-38. Epub 2020/08/08. doi: 10.1073/pnas.2008211117. PubMed PMID: 32759209; PMCID: PMC7443880. Daruwalla A, Zhang J, Lee HJ, Khadka N, Farquhar ER, Shi W, von Lintig J, Kiser PD. Structural basis for carotenoid cleavage by an archaeal carotenoid dioxygenase. Proc Natl Acad Sci U S A. 2020;117(33):19914-25. Epub 2020/08/05. doi: 10.1073/pnas.2004116117. PubMed PMID: 32747548; PMCID: PMC7443882. Khadka N, Farquhar ER, Hill HE, Shi W, von Lintig J, Kiser PD. Evidence for distinct rate-limiting steps in the cleavage of alkenes by carotenoid cleavage dioxygenases. J Biol Chem. 2019;294(27):10596-606. Epub 2019/05/30. doi: 10.1074/jbc.RA119.007535. PubMed PMID: 31138651; PMCID: PMC6615678. Kiser PD, Kolesnikov AV, Kiser JZ, Dong Z, Chaurasia B, Wang L, Summers SA, Hoang T, Blackshaw S, Peachey NS, Kefalov VJ, Palczewski K. Conditional deletion of Des1 in the mouse retina does not impair the visual cycle in cones. FASEB J. 2019;33(4):fj201802493R. Epub 2019/01/16. doi: 10.1096/fj.201802493R. PubMed PMID: 30645148; PMCID: PMC6436658. Silvaroli JA, Widjaja-Adhi MAK, Trischman T, Chelstowska S, Horwitz S, Banerjee S, Kiser PD, Blaner WS, Golczak M. Abnormal cannabidiol modulates vitamin A metabolism by acting as a competitive inhibitor of CRBP1. ACS Chem Biol. 2019;14(3):434-48. Epub 2019/02/06. doi: 10.1021/acschembio.8b01070. PubMed PMID: 30721022; PMCID: PMC6420351. Daruwalla A, Kiser PD. Structural and mechanistic aspects of carotenoid cleavage dioxygenases (CCDs). Biochim Biophys Acta Mol Cell Biol Lipids. 2019:158590. Epub 2019/12/25. doi: 10.1016/j.bbalip.2019.158590. PubMed PMID: 31874225. Zhang J, Choi EH, Tworak A, Salom D, Leinonen H, Sander CL, Hoang TV, Handa JT, Blackshaw S, Palczewska G, Kiser PD, Palczewski K. Photic generation of 11-cis-retinal in bovine retinal pigment epithelium. J Biol Chem. 2019;294(50):19137-54. Epub 2019/11/07. doi: 10.1074/jbc.RA119.011169. PubMed PMID: 31694912; PMCID: PMC6916499. Montano MM, Yeh IJ, Chen Y, Hernandez C, Kiselar JG, de la Fuente M, Lawes AM, Nieman MT, Kiser PD, Jacobberger J, Exner AA, Lawes MC. Inhibition of the histone demethylase, KDM5B, directly induces re-expression of tumor suppressor protein HEXIM1 in cancer cells. Breast Cancer Res. 2019;21(1):138. Epub 2019/12/07. doi: 10.1186/s13058-019-1228-7. PubMed PMID: 31805991; PMCID: PMC6896798. Kiser PD. Alkene-cleaving carotenoid cleavage dioxygenases. In: Scott RA, editor. Encyclopedia of Inorganic and Bioinorganic Chemistry: John Wiley & Sons, Ltd; 2019. p. 1-13. 2006-2018 Sander CL, Luu J, Kim K, Furkert D, Jang K, Reichenwallner J, Kang M, Lee HJ, Eger BT, Choe HW, Fiedler D, Ernst OP, Kim YJ, Palczewski K, Kiser PD. Structural evidence for visual arrestin priming via complexation of phosphoinositols. Structure. 2022;30(2):263-77 e5. Epub 20211021. doi: 10.1016/j.str.2021.10.002. PubMed PMID: 34678158; PMCID: PMC8818024. Daruwalla A, Sui X, Kiser PD. Preparation of carotenoid cleavage dioxygenases for X-ray crystallography. Methods Enzymol. 2022;671:243-71. Epub 20211122. doi: 10.1016/bs.mie.2021.10.020. Kiser PD. Retinal Pigment Epithelium 65 kDa Protein (RPE65): An Update. Prog Retin Eye Res. 2021:101013. Epub 2021/10/05. doi: 10.1016/j.preteyeres.2021.101013. PubMed PMID: 34607013. Occelli LM, Daruwalla A, De Silva SR, Winkler PA, Sun K, Pasmanter N, Minella A, Querubin J, Lyons LA, Consortium L, Robson AG, Heon E, Michaelides M, Webster AR, Palczewski K, Vincent A, Mahroo OA, Kiser PD, Petersen-Jones SM. A large animal model of RDH5-associated retinopathy recapitulates important features of the human phenotype. Hum Mol Genet. 2021. Epub 2021/11/03. doi: 10.1093/hmg/ddab316. PubMed PMID: 34726233. Choi EH, Suh S, Einstein DE, Leinonen H, Dong Z, Rao SR, Fliesler SJ, Blackshaw S, Yu M, Peachey NS, Palczewski K, Kiser PD. An inducible Cre mouse for studying roles of the RPE in retinal physiology and disease. JCI Insight. 2021;6(9). Epub 2021/03/31. doi: 10.1172/jci.insight.146604. PubMed PMID: 33784255. York NJ, Lockart MM, Sardar S, Khadka N, Shi W, Stenkamp RE, Zhang J, Kiser PD, Pierce BS. Structure of 3-mercaptopropionic acid dioxygenase with a substrate analog reveals bidentate substrate binding at the iron center. J Biol Chem. 2021:100492. Epub 2021/03/05. doi: 10.1016/j.jbc.2021.100492. PubMed PMID: 33662397; PMCID: PMC8050391. Kiser PD, Palczewski K. Pathways and disease-causing alterations in visual chromophore production for vertebrate vision. J Biol Chem. 2021;296:100072. Epub 2020/11/15. doi: 10.1074/jbc.REV120.014405. PubMed PMID: 33187985; PMCID: PMC7948990. Kolesnikov AV, Kiser PD, Palczewski K, Kefalov VJ. Function of mammalian M-cones depends on the level of CRALBP in Muller cells. J Gen Physiol. 2021;153(1). Epub 2020/11/21. doi: 10.1085/jgp.202012675. PubMed PMID: 33216847; PMCID: PMC7685772. Bandara S, Thomas LD, Ramkumar S, Khadka N, Kiser PD, Golczak M, von Lintig J. The Structural and Biochemical Basis of Apocarotenoid Processing by beta-Carotene Oxygenase-2. ACS Chem Biol. 2021;16(3):480-90. Epub 2021/02/19. doi: 10.1021/acschembio.0c00832. PubMed PMID: 33600157; PMCID: PMC8082539. Suh S, Choi EH, Leinonen H, Foik AT, Newby GA, Yeh WH, Dong Z, Kiser PD, Lyon DC, Liu DR, Palczewski K. Restoration of visual function in adult mice with an inherited retinal disease via adenine base editing. Nat Biomed Eng. 2021;5(2):169-78. Epub 2020/10/21. doi: 10.1038/s41551-020-00632-6. PubMed PMID: 33077938; PMCID: PMC7885272. Sander CL, Sears AE, Pinto AFM, Choi EH, Kahremany S, Gao F, Salom D, Jin H, Pardon E, Suh S, Dong Z, Steyaert J, Saghatelian A, Skowronska-Krawczyk D, Kiser PD, Palczewski K. Nano-scale resolution of native retinal rod disk membranes reveals differences in lipid composition. J Cell Biol. 2021;220(8). Epub 2021/06/17. doi: 10.1083/jcb.202101063. PubMed PMID: 34132745; PMCID: PMC8240855. Blum E, Zhang J, Zaluski J, Einstein DE, Korshin E, Kubas A, Gruzman A, Tochtrop GP, Kiser PD, Palczewski K. Rational alteration of pharmacokinetics of chiral fluorinated and deuterated derivatives of emixustat for retina therapies. J Med Chem. 2021;64(12):8287-302. Thomas LD, Bandara S, Parmar VM, Srinivasagan R, Khadka N, Golczak M, Kiser PD, von Lintig J. The human mitochondrial enzyme BCO2 exhibits catalytic activity toward carotenoids and apocarotenoids. J Biol Chem. 2020;295(46):15553-65. Epub 2020/09/03. doi: 10.1074/jbc.RA120.015515. PubMed PMID: 32873706. Kakodkar P, More S, Andras K, Papakonstantinou N, Kelly S, Makrooni MA, Ortutay C, Szegezdi E. Aspartic Aminopeptidase Is a Novel Biomarker of Aggressive Chronic Lymphocytic Leukemia. Cancers (Basel). 2020;12(7). Epub 2020/07/16. doi: 10.3390/cancers12071876. PubMed PMID: 32664705; PMCID: PMC7408864. Gazda MA, Toomey MB, Araujo PM, Lopes RJ, Afonso S, Myers CA, Serres K, Kiser PD, Hill GE, Corbo JC, Carneiro M. Genetic Basis of De Novo Appearance of Carotenoid Ornamentation in Bare-Parts of Canaries. Mol Biol Evol. 2020;37(5):1317-28. Epub 2020/01/14. doi: 10.1093/molbev/msaa006. PubMed PMID: 31930402. Sears AE, Albiez S, Gulati S, Wang B, Kiser P, Kovacik L, Engel A, Stahlberg H, Palczewski K. Single particle cryo-EM of the complex between interphotoreceptor retinoid-binding protein and a monoclonal antibody. FASEB J. 2020;34(10):13918-34. Epub 2020/08/30. doi: 10.1096/fj.202000796RR. PubMed PMID: 32860273; PMCID: PMC7589273. Palczewski K, Kiser PD. Shedding new light on the generation of the visual chromophore. Proc Natl Acad Sci U S A. 2020;117(33):19629-38. Epub 2020/08/08. doi: 10.1073/pnas.2008211117. PubMed PMID: 32759209; PMCID: PMC7443880. Daruwalla A, Zhang J, Lee HJ, Khadka N, Farquhar ER, Shi W, von Lintig J, Kiser PD. Structural basis for carotenoid cleavage by an archaeal carotenoid dioxygenase. Proc Natl Acad Sci U S A. 2020;117(33):19914-25. Epub 2020/08/05. doi: 10.1073/pnas.2004116117. PubMed PMID: 32747548; PMCID: PMC7443882. Khadka N, Farquhar ER, Hill HE, Shi W, von Lintig J, Kiser PD. Evidence for distinct rate-limiting steps in the cleavage of alkenes by carotenoid cleavage dioxygenases. J Biol Chem. 2019;294(27):10596-606. Epub 2019/05/30. doi: 10.1074/jbc.RA119.007535. PubMed PMID: 31138651; PMCID: PMC6615678. Kiser PD, Kolesnikov AV, Kiser JZ, Dong Z, Chaurasia B, Wang L, Summers SA, Hoang T, Blackshaw S, Peachey NS, Kefalov VJ, Palczewski K. Conditional deletion of Des1 in the mouse retina does not impair the visual cycle in cones. FASEB J. 2019;33(4):fj201802493R. Epub 2019/01/16. doi: 10.1096/fj.201802493R. PubMed PMID: 30645148; PMCID: PMC6436658. Silvaroli JA, Widjaja-Adhi MAK, Trischman T, Chelstowska S, Horwitz S, Banerjee S, Kiser PD, Blaner WS, Golczak M. Abnormal cannabidiol modulates vitamin A metabolism by acting as a competitive inhibitor of CRBP1. ACS Chem Biol. 2019;14(3):434-48. Epub 2019/02/06. doi: 10.1021/acschembio.8b01070. PubMed PMID: 30721022; PMCID: PMC6420351. Daruwalla A, Kiser PD. Structural and mechanistic aspects of carotenoid cleavage dioxygenases (CCDs). Biochim Biophys Acta Mol Cell Biol Lipids. 2019:158590. Epub 2019/12/25. doi: 10.1016/j.bbalip.2019.158590. PubMed PMID: 31874225. Zhang J, Choi EH, Tworak A, Salom D, Leinonen H, Sander CL, Hoang TV, Handa JT, Blackshaw S, Palczewska G, Kiser PD, Palczewski K. Photic generation of 11-cis-retinal in bovine retinal pigment epithelium. J Biol Chem. 2019;294(50):19137-54. Epub 2019/11/07. doi: 10.1074/jbc.RA119.011169. PubMed PMID: 31694912; PMCID: PMC6916499. Montano MM, Yeh IJ, Chen Y, Hernandez C, Kiselar JG, de la Fuente M, Lawes AM, Nieman MT, Kiser PD, Jacobberger J, Exner AA, Lawes MC. Inhibition of the histone demethylase, KDM5B, directly induces re-expression of tumor suppressor protein HEXIM1 in cancer cells. Breast Cancer Res. 2019;21(1):138. Epub 2019/12/07. doi: 10.1186/s13058-019-1228-7. PubMed PMID: 31805991; PMCID: PMC6896798. Kiser PD. Alkene-cleaving carotenoid cleavage dioxygenases. In: Scott RA, editor. Encyclopedia of Inorganic and Bioinorganic Chemistry: John Wiley & Sons, Ltd; 2019. p. 1-13. Daruwalla A, Choi EH, Palczewski K, Kiser PD. Structural biology of 11-cis-retinaldehyde production in the classical visual cycle. Biochem J. 2018;475(20):3171-88. Epub 2018/10/26. doi: 10.1042/BCJ20180193. PubMed PMID: 30352831. Gulati S, Jin H, Masuho I, Orban T, Cai Y, Pardon E, Martemyanov KA, Kiser PD, Stewart PL, Ford CP, Steyaert J, Palczewski K. Targeting G protein-coupled receptor signaling at the G protein level with a selective nanobody inhibitor. Nat Commun. 2018;9(1):1996. Epub 2018/05/20. doi: 10.1038/s41467-018-04432-0. PubMed PMID: 29777099; PMCID: PMC5959942. Kiser PD, Zhang J, Sharma A, Angueyra JM, Kolesnikov AV, Badiee M, Tochtrop GP, Kinoshita J, Peachey NS, Li W, Kefalov VJ, Palczewski K. Retinoid isomerase inhibitors impair but do not block mammalian cone photoreceptor function. J Gen Physiol. 2018;150(4):571-90. Epub 2018/03/04. doi: 10.1085/jgp.201711815. PubMed PMID: 29500274; PMCID: PMC5881442. Choi EH, Suh S, Sander CL, Hernandez CJO, Bulman ER, Khadka N, Dong Z, Shi W, Palczewski K, Kiser PD. Insights into the pathogenesis of dominant retinitis pigmentosa associated with a D477G mutation in RPE65. Hum Mol Genet. 2018;27(13):2225-43. Epub 2018/04/17. doi: 10.1093/hmg/ddy128. PubMed PMID: 29659842. Orban T, Leinonen H, Getter T, Dong Z, Sun W, Gao S, Veenstra A, Heidari-Torkabadi H, Kern TS, Kiser PD, Palczewski K. A Combination of G Protein-Coupled Receptor Modulators Protects Photoreceptors from Degeneration. J Pharmacol Exp Ther. 2018;364(2):207-20. Epub 2017/11/23. doi: 10.1124/jpet.117.245167. PubMed PMID: 29162627; PMCID: PMC5771314. Kelly ME, Ramkumar S, Sun W, Colon Ortiz C, Kiser PD, Golczak M, von Lintig J. The Biochemical Basis of Vitamin A Production from the Asymmetric Carotenoid beta-Cryptoxanthin. ACS Chem Biol. 2018;13(8):2121-9. Epub 2018/06/09. doi: 10.1021/acschembio.8b00290. PubMed PMID: 29883100; PMCID: PMC6158786. Sui X, Farquhar ER, Hill HE, von Lintig J, Shi W, Kiser PD. Preparation and characterization of metal-substituted carotenoid cleavage oxygenases. J Biol Inorg Chem. 2018;23(6):887-901. Epub 2018/06/28. doi: 10.1007/s00775-018-1586-0. PubMed PMID: 29946976. Silvaroli JA, Pleshinger MJ, Banerjee S, Kiser PD, Golczak M. Enzyme That Makes You Cry-Crystal Structure of Lachrymatory Factor Synthase from Allium cepa. ACS Chem Biol. 2017;12(9):2296-304. doi: 10.1021/acschembio.7b00336. PubMed PMID: 28708375. Gulati S, Jastrzebska B, Banerjee S, Placeres AL, Miszta P, Gao S, Gunderson K, Tochtrop GP, Filipek S, Katayama K, Kiser PD, Mogi M, Stewart PL, Palczewski K. Photocyclic behavior of rhodopsin induced by an atypical isomerization mechanism. Proc Natl Acad Sci USA. 2017;114(13):E2608-E15. doi: 10.1073/pnas.1617446114. PubMed PMID: 28289214; PMCID: PMC5380078. Sui X, Weitz AC, Farquhar ER, Badiee M, Banerjee S, von Lintig J, Tochtrop GP, Palczewski K, Hendrich MP, Kiser PD. Structure and Spectroscopy of Alkene-Cleaving Dioxygenases Containing an Atypically Coordinated Non-Heme Iron Center. Biochemistry. 2017;56(22):2836-52. doi: 10.1021/acs.biochem.7b00251. PubMed PMID: 28493664. Kiser PD. Reappraisal of dioxygen binding in NOV1 crystal structures. 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FASEB J. 2019 Aug;33(8):9526-9539. doi: 10.1096/fj.201900443RR. Epub 2019 May 23.PMID: 31121099 Mustafi D, Arbabi A, Ameri H, Palczewski K. Retinal Gene Distribution and Functionality Implicated in Inherited Retinal Degenerations Can Reveal Disease-Relevant Pathways for Pharmacologic Intervention. Pharmaceuticals (Basel). 2019 May 17;12(2):74. doi: 10.3390/ph12020074.PMID: 31108889 Getter T, Suh S, Hoang T, Handa JT, Dong Z, Ma X, Chen Y, Blackshaw S, Palczewski K. The selective estrogen receptor modulator raloxifene mitigates the effect of all-trans-retinal toxicity in photoreceptor degeneration. J Biol Chem. 2019 Jun 14;294(24):9461-9475. doi: 10.1074/jbc.RA119.008697. Epub 2019 May 9.PMID: 31073029 Liu H, Tang J, Du Y, Saadane A, Samuels I, Veenstra A, Kiser JZ, Palczewski K, Kern TS. Transducin1, Phototransduction and the Development of Early Diabetic Retinopathy. Invest Ophthalmol Vis Sci. 2019 Apr 1;60(5):1538-1546. doi: 10.1167/iovs.18-26433.PMID: 30994864 Salom D, Jin H, Gerken TA, Yu C, Huang L, Palczewski K. Human red and green cone opsins are O-glycosylated at an N-terminal Ser/Thr-rich domain conserved in vertebrates. J Biol Chem. 2019 May 17;294(20):8123-8133. doi: 10.1074/jbc.RA118.006835. Epub 2019 Apr 4.PMID: 30948514 Leinonen H, Choi EH, Gardella A, Kefalov VJ, Palczewski K. A Mixture of U.S. Food and Drug Administration-Approved Monoaminergic Drugs Protects the Retina From Light Damage in Diverse Models of Night Blindness. Invest Ophthalmol Vis Sci. 2019 Apr 1;60(5):1442-1453. doi: 10.1167/iovs.19-26560.PMID: 30947334 Gulati S, Palczewski K, Engel A, Stahlberg H, Kovacik L. Cryo-EM structure of phosphodiesterase 6 reveals insights into the allosteric regulation of type I phosphodiesterases. Sci Adv. 2019 Feb 27;5(2):eaav4322. doi: 10.1126/sciadv.aav4322. eCollection 2019 Feb.PMID: 30820458 Katayama K, Gulati S, Ortega JT, Alexander NS, Sun W, Shenouda MM, Palczewski K, Jastrzebska B. Specificity of the chromophore-binding site in human cone opsins. J Biol Chem. 2019 Apr 12;294(15):6082-6093. doi: 10.1074/jbc.RA119.007587. Epub 2019 Feb 15.PMID: 30770468 Kiser PD, Kolesnikov AV, Kiser JZ, Dong Z, Chaurasia B, Wang L, Summers SA, Hoang T, Blackshaw S, Peachey NS, Kefalov VJ, Palczewski K. Conditional deletion of Des1 in the mouse retina does not impair the visual cycle in cones. FASEB J. 2019 Apr;33(4):5782-5792. doi: 10.1096/fj.201802493R. Epub 2019 Jan 15.PMID: 30645148 Sakami S, Imanishi Y, Palczewski K. Müller glia phagocytose dead photoreceptor cells in a mouse model of retinal degenerative disease. FASEB J. 2019 Mar;33(3):3680-3692. doi: 10.1096/fj.201801662R. Epub 2018 Nov 21.PMID: 30462532 Sato S, Jastrzebska B, Engel A, Palczewski K, Kefalov VJ. Apo-Opsin Exists in Equilibrium Between a Predominant Inactive and a Rare Highly Active State. J Neurosci. 2019 Jan 9;39(2):212-223. doi: 10.1523/JNEUROSCI.1980-18.2018. Epub 2018 Nov 20.PMID: 30459230 Daruwalla A, Choi EH, Palczewski K, Kiser PD. Structural biology of 11-cis-retinaldehyde production in the classical visual cycle. Biochem J. 2018 Oct 22;475(20):3171-3188. doi: 10.1042/BCJ20180193.PMID: 30352831 Review. Palczewska G, Kern TS, Palczewski K. Noninvasive Two-Photon Microscopy Imaging of Mouse Retina and Retinal Pigment Epithelium. Methods Mol Biol. 2019;1834:333-343. doi: 10.1007/978-1-4939-8669-9_21.PMID: 30324453 Sakami S, Palczewski K. Immuno-TEM/STEM in Retinal Research. Methods Mol Biol. 2019;1834:311-332. doi: 10.1007/978-1-4939-8669-9_20.PMID: 30324452 Chan HCS, Wang J, Palczewski K, Filipek S, Vogel H, Liu ZJ, Yuan S. Exploring a new ligand binding site of G protein-coupled receptors. Chem Sci. 2018 Jul 13;9(31):6480-6489. doi: 10.1039/c8sc01680a. eCollection 2018 Aug 21.PMID: 30310578 Behnen P, Felline A, Comitato A, Di Salvo MT, Raimondi F, Gulati S, Kahremany S, Palczewski K, Marigo V, Fanelli F. A Small Chaperone Improves Folding and Routing of Rhodopsin Mutants Linked to Inherited Blindness. iScience. 2018 Jun 29;4:1-19. doi: 10.1016/j.isci.2018.05.001. Epub 2018 May 5.PMID: 30240733 Palczewska G, Stremplewski P, Suh S, Alexander N, Salom D, Dong Z, Ruminski D, Choi EH, Sears AE, Kern TS, Wojtkowski M, Palczewski K. Two-photon imaging of the mammalian retina with ultrafast pulsing laser. JCI Insight. 2018 Sep 6;3(17):e121555. doi: 10.1172/jci.insight.121555. eCollection 2018 Sep 6.PMID: 30185665 Gao S, Parmar T, Palczewska G, Dong Z, Golczak M, Palczewski K, Jastrzebska B. Protective Effect of a Locked Retinal Chromophore Analog against Light-Induced Retinal Degeneration. Mol Pharmacol. 2018 Oct;94(4):1132-1144. doi: 10.1124/mol.118.112581. Epub 2018 Jul 17.PMID: 30018116 Gulati S, Jin H, Masuho I, Orban T, Cai Y, Pardon E, Martemyanov KA, Kiser PD, Stewart PL, Ford CP, Steyaert J, Palczewski K. Targeting G protein-coupled receptor signaling at the G protein level with a selective nanobody inhibitor. Nat Commun. 2018 May 18;9(1):1996. doi: 10.1038/s41467-018-04432-0.PMID: 29777099 Chen Y, Chen Y, Jastrzebska B, Golczak M, Gulati S, Tang H, Seibel W, Li X, Jin H, Han Y, Gao S, Zhang J, Liu X, Heidari-Torkabadi H, Stewart PL, Harte WE, Tochtrop GP, Palczewski K. A novel small molecule chaperone of rod opsin and its potential therapy for retinal degeneration. Nat Commun. 2018 May 17;9(1):1976. doi: 10.1038/s41467-018-04261-1.PMID: 29773803 Choi EH, Suh S, Sander CL, Hernandez CJO, Bulman ER, Khadka N, Dong Z, Shi W, Palczewski K, Kiser PD. Insights into the pathogenesis of dominant retinitis pigmentosa associated with a D477G mutation in RPE65. Hum Mol Genet. 2018 Jul 1;27(13):2225-2243. doi: 10.1093/hmg/ddy128.PMID: 29659842 Trifonov L, Afri M, Palczewski K, Korshin EE, Gruzman A. An Expedient Synthesis of CMF-019: (S)-5-Methyl-3-{1-(pentan-3-yl)-2- (thiophen-2-ylmethyl)-1H-benzo[d]imidazole-5-carboxamido}hexanoic Acid, a Potent Apelin Receptor (APJ) Agonist. Med Chem. 2018;14(7):688-694. doi: 10.2174/1573406414666180412154952.PMID: 29651942 Kiser PD, Zhang J, Sharma A, Angueyra JM, Kolesnikov AV, Badiee M, Tochtrop GP, Kinoshita J, Peachey NS, Li W, Kefalov VJ, Palczewski K. Retinoid isomerase inhibitors impair but do not block mammalian cone photoreceptor function. J Gen Physiol. 2018 Apr 2;150(4):571-590. doi: 10.1085/jgp.201711815. Epub 2018 Mar 2.PMID: 29500274 Luu J, Palczewski K. Human aging and disease: Lessons from age-related macular degeneration. Proc Natl Acad Sci U S A. 2018 Mar 20;115(12):2866-2872. doi: 10.1073/pnas.1721033115. Epub 2018 Feb 26.PMID: 29483257 Gao S, Kahremany S, Zhang J, Jastrzebska B, Querubin J, Petersen-Jones SM, Palczewski K. Retinal-chitosan Conjugates Effectively Deliver Active Chromophores to Retinal Photoreceptor Cells in Blind Mice and Dogs. Mol Pharmacol. 2018 May;93(5):438-452. doi: 10.1124/mol.117.111294. Epub 2018 Feb 16.PMID: 29453250 Schur RM, Gao S, Yu G, Chen Y, Maeda A, Palczewski K, Lu ZR. New GABA modulators protect photoreceptor cells from light-induced degeneration in mouse models. FASEB J. 2018 Jun;32(6):3289-3300. doi: 10.1096/fj.201701250R. Epub 2018 Jan 24.PMID: 29401616 Owen TS, Salom D, Sun W, Palczewski K. Increasing the Stability of Recombinant Human Green Cone Pigment. Biochemistry. 2018 Feb 13;57(6):1022-1030. doi: 10.1021/acs.biochem.7b01118. Epub 2018 Jan 29.PMID: 29320632 2014-2017 Murashova GA, Mancuso CA, Canfield JL, Sakami S, Palczewski K, Palczewska G, Dantus M. Multimodal nonlinear optical imaging of unstained retinas in the epi-direction with a sub-40 fs Yb-fiber laser. Biomed Opt Express. 2017 Oct 26;8(11):5228-5242. doi: 10.1364/BOE.8.005228. eCollection 2017 Nov 1.PMID: 29188116 Orban T, Leinonen H, Getter T, Dong Z, Sun W, Gao S, Veenstra A, Heidari-Torkabadi H, Kern TS, Kiser PD, Palczewski K. A Combination of G Protein-Coupled Receptor Modulators Protects Photoreceptors from Degeneration. J Pharmacol Exp Ther. 2018 Feb;364(2):207-220. doi: 10.1124/jpet.117.245167. Epub 2017 Nov 21.PMID: 29162627 Penberthy KK, Rival C, Shankman LS, Raymond MH, Zhang J, Perry JSA, Lee CS, Han CZ, Onengut-Gumuscu S, Palczewski K, Lysiak JJ, Ravichandran KS. Context-dependent compensation among phosphatidylserine-recognition receptors. Sci Rep. 2017 Nov 7;7(1):14623. doi: 10.1038/s41598-017-15191-1.PMID: 29116131 Kolesnikov AV, Orban T, Jin H, Brooks C, Hofmann L, Dong Z, Sokolov M, Palczewski K, Kefalov VJ. Dephosphorylation by protein phosphatase 2A regulates visual pigment regeneration and the dark adaptation of mammalian photoreceptors. Proc Natl Acad Sci U S A. 2017 Nov 7;114(45):E9675-E9684. doi: 10.1073/pnas.1712405114. Epub 2017 Oct 23.PMID: 29078372 Murashova GA, Mancuso CA, Sakami S, Palczewski K, Palczewska G, Dantus M. Epi-direction detected multimodal imaging of an unstained mouse retina with a Yb-fiber laser. Proc SPIE Int Soc Opt Eng. 2017 Mar;10069:100692K. doi: 10.1117/12.2252457.PMID: 28989217 Chiang CK, Tworak A, Kevany BM, Xu B, Mayne J, Ning Z, Figeys D, Palczewski K. Quantitative phosphoproteomics reveals involvement of multiple signaling pathways in early phagocytosis by the retinal pigmented epithelium. J Biol Chem. 2017 Dec 1;292(48):19826-19839. doi: 10.1074/jbc.M117.812677. Epub 2017 Oct 4.PMID: 28978645 Chan HCS, McCarthy D, Li J, Palczewski K, Yuan S. Designing Safer Analgesics via μ-Opioid Receptor Pathways. Trends Pharmacol Sci. 2017 Nov;38(11):1016-1037. doi: 10.1016/j.tips.2017.08.004. Epub 2017 Sep 19.PMID: 28935293 Review. Sears AE, Bernstein PS, Cideciyan AV, Hoyng C, Charbel Issa P, Palczewski K, Rosenfeld PJ, Sadda S, Schraermeyer U, Sparrow JR, Washington I, Scholl HPN. Towards Treatment of Stargardt Disease: Workshop Organized and Sponsored by the Foundation Fighting Blindness. Transl Vis Sci Technol. 2017 Sep 14;6(5):6. doi: 10.1167/tvst.6.5.6. eCollection 2017 Sep.PMID: 28920007 Review. Alexander NS, Palczewski K. Crowd sourcing difficult problems in protein science. Protein Sci. 2017 Nov;26(11):2118-2125. doi: 10.1002/pro.3247. Epub 2017 Aug 29.PMID: 28762619 Review. Tonade D, Liu H, Palczewski K, Kern TS. Photoreceptor cells produce inflammatory products that contribute to retinal vascular permeability in a mouse model of diabetes. Diabetologia. 2017 Oct;60(10):2111-2120. doi: 10.1007/s00125-017-4381-5. Epub 2017 Jul 28.PMID: 28755268 Sun D, Sahu B, Gao S, Schur RM, Vaidya AM, Maeda A, Palczewski K, Lu ZR. Targeted Multifunctional Lipid ECO Plasmid DNA Nanoparticles as Efficient Non-viral Gene Therapy for Leber's Congenital Amaurosis. Mol Ther Nucleic Acids. 2017 Jun 16;7:42-52. doi: 10.1016/j.omtn.2017.02.005. Epub 2017 Feb 28.PMID: 28624218 Xue Y, Sato S, Razafsky D, Sahu B, Shen SQ, Potter C, Sandell LL, Corbo JC, Palczewski K, Maeda A, Hodzic D, Kefalov VJ. The role of retinol dehydrogenase 10 in the cone visual cycle. Sci Rep. 2017 May 24;7(1):2390. doi: 10.1038/s41598-017-02549-8.PMID: 28539612 Sui X, Weitz AC, Farquhar ER, Badiee M, Banerjee S, von Lintig J, Tochtrop GP, Palczewski K, Hendrich MP, Kiser PD. Structure and Spectroscopy of Alkene-Cleaving Dioxygenases Containing an Atypically Coordinated Non-Heme Iron Center. Biochemistry. 2017 Jun 6;56(22):2836-2852. doi: 10.1021/acs.biochem.7b00251. Epub 2017 May 19.PMID: 28493664 Alexander NS, Katayama K, Sun W, Salom D, Gulati S, Zhang J, Mogi M, Palczewski K, Jastrzebska Complex binding pathways determine the regeneration of mammalian green cone opsin with a locked retinal analogue. J Biol Chem. 2017 Jun 30;292(26):10983-10997. doi: 10.1074/jbc.M117.780478. Epub 2017 May 9.PMID: 28487362 Kiser PD, Zhang J, Badiee M, Kinoshita J, Peachey NS, Tochtrop GP, Palczewski K. Rational Tuning of Visual Cycle Modulator Pharmacodynamics. J Pharmacol Exp Ther. 2017 Jul;362(1):131-145. doi: 10.1124/jpet.117.240721. Epub 2017 May 5.PMID: 28476927 Hofmann L, Alexander NS, Sun W, Zhang J, Orban T, Palczewski K. Hydrogen/Deuterium Exchange Mass Spectrometry of Human Green Opsin Reveals a Conserved Pro-Pro Motif in Extracellular Loop 2 of Monostable Visual G Protein-Coupled Receptors. Biochemistry. 2017 May 2;56(17):2338-2348. doi: 10.1021/acs.biochem.7b00165. Epub 2017 Apr 21.PMID: 28402104 Palczewski K. Skunkworks project for Big Pharma. Pharmacol Res. 2017 Oct;124:167-168. doi: 10.1016/j.phrs.2017.03.022. Epub 2017 Mar 28.PMID: 28363722 No abstract available. Gulati S, Jastrzebska B, Banerjee S, Placeres ÁL, Miszta P, Gao S, Gunderson K, Tochtrop GP, Filipek S, Katayama K, Kiser PD, Mogi M, Stewart PL, Palczewski K. Photocyclic behavior of rhodopsin induced by an atypical isomerization mechanism. Proc Natl Acad Sci U S A. 2017 Mar 28;114(13):E2608-E2615. doi: 10.1073/pnas.1617446114. Epub 2017 Mar 13.PMID: 28289214 Mustafi D, Kevany BM, Bai X, Golczak M, Adams MD, Wynshaw-Boris A, Palczewski K. Transcriptome analysis reveals rod/cone photoreceptor specific signatures across mammalian retinas. Hum Mol Genet. 2016 Oct 15;25(20):4376-4388. doi: 10.1093/hmg/ddw268.PMID: 28172828 Sharma R, Schwarz C, Hunter JJ, Palczewska G, Palczewski K, Williams DR. Formation and Clearance of All-Trans-Retinol in Rods Investigated in the Living Primate Eye With Two-Photon Ophthalmoscopy. Invest Ophthalmol Vis Sci. 2017 Jan 1;58(1):604-613. doi: 10.1167/iovs.16-20061.PMID: 28129424 Sundermeier TR, Sakami S, Sahu B, Howell SJ, Gao S, Dong Z, Golczak M, Maeda A, Palczewski K. MicroRNA-processing Enzymes Are Essential for Survival and Function of Mature Retinal Pigmented Epithelial Cells in Mice. J Biol Chem. 2017 Feb 24;292(8):3366-3378. doi: 10.1074/jbc.M116.770024. Epub 2017 Jan 19.PMID: 28104803 Athanasiou D, Aguila M, Opefi CA, South K, Bellingham J, Bevilacqua D, Munro PM, Kanuga N, Mackenzie FE, Dubis AM, Georgiadis A, Graca AB, Pearson RA, Ali RR, Sakami S, Palczewski K, Sherman MY, Reeves PJ, Cheetham ME. Rescue of mutant rhodopsin traffic by metformin-induced AMPK activation accelerates photoreceptor degeneration. Hum Mol Genet. 2017 Jan 15;26(2):305-319. doi: 10.1093/hmg/ddw387.PMID: 28065882 Jastrzebska B, Comar WD, Kaliszewski MJ, Skinner KC, Torcasio MH, Esway AS, Jin H, Palczewski K, Smith AW. A G Protein-Coupled Receptor Dimerization Interface in Human Cone Opsins. Biochemistry. 2017 Jan 10;56(1):61-72. doi: 10.1021/acs.biochem.6b00877. Epub 2016 Nov 29.PMID: 28045251 Schwarz C, Sharma R, Fischer WS, Chung M, Palczewska G, Palczewski K, Williams DR, Hunter JJ. Safety assessment in macaques of light exposures for functional two-photon ophthalmoscopy in humans. Biomed Opt Express. 2016 Nov 16;7(12):5148-5169. doi: 10.1364/BOE.7.005148. eCollection 2016 Dec 1.PMID: 28018732 Kiser PD, Palczewski K. Retinoids and Retinal Diseases. Annu Rev Vis Sci. 2016 Oct;2:197-234. doi: 10.1146/annurev-vision-111815-114407. Epub 2016 Jul 18.PMID: 27917399 Review. Palczewska G, Maeda A, Golczak M, Arai E, Dong Z, Perusek L, Kevany B, Palczewski K. Receptor MER Tyrosine Kinase Proto-oncogene (MERTK) Is Not Required for Transfer of Bis-retinoids to the Retinal Pigmented Epithelium. J Biol Chem. 2016 Dec 23;291(52):26937-26949. doi: 10.1074/jbc.M116.764563. Epub 2016 Nov 14.PMID: 27875314 Chen Y, Brooks MJ, Gieser L, Swaroop A, Palczewski K. Transcriptome profiling of NIH3T3 cell lines expressing opsin and the P23H opsin mutant identifies candidate drugs for the treatment of retinitis pigmentosa. Pharmacol Res. 2017 Jan;115:1-13. doi: 10.1016/j.phrs.2016.10.031. Epub 2016 Nov 9.PMID: 27838510 Hofmann L, Tsybovsky Y, Alexander NS, Babino D, Leung NY, Montell C, Banerjee S, von Lintig J, Palczewski K. Structural Insights into the Drosophila melanogaster Retinol Dehydrogenase, a Member of the Short-Chain Dehydrogenase/Reductase Family. Biochemistry. 2016 Nov 29;55(47):6545-6557. doi: 10.1021/acs.biochem.6b00907. Epub 2016 Nov 16.PMID: 27809489 Chen Y, Kern TS, Kiser PD, Palczewski K. Eyes on systems pharmacology. Pharmacol Res. 2016 Dec;114:39-41. doi: 10.1016/j.phrs.2016.09.026. Epub 2016 Oct 5.PMID: 27720767 No abstract available. Rajavel M, Orban T, Xu M, Hernandez-Sanchez W, de la Fuente M, Palczewski K, Taylor DJ. Dynamic peptides of human TPP1 fulfill diverse functions in telomere maintenance. Nucleic Acids Res. 2016 Dec 1;44(21):10467-10479. doi: 10.1093/nar/gkw846. Epub 2016 Sep 20.PMID: 27655633 Liu H, Tang J, Du Y, Saadane A, Tonade D, Samuels I, Veenstra A, Palczewski K, Kern TS. Photoreceptor Cells Influence Retinal Vascular Degeneration in Mouse Models of Retinal Degeneration and Diabetes. Invest Ophthalmol Vis Sci. 2016 Aug 1;57(10):4272-81. doi: 10.1167/iovs.16-19415.PMID: 27548901 Chen Y, Palczewska G, Masuho I, Gao S, Jin H, Dong Z, Gieser L, Brooks MJ, Kiser PD, Kern TS, Martemyanov KA, Swaroop A, Palczewski K. Synergistically acting agonists and antagonists of G protein-coupled receptors prevent photoreceptor cell degeneration. Sci Signal. 2016 Jul 26;9(438):ra74. doi: 10.1126/scisignal.aag0245.PMID: 27460988 Yuan S, Chan HC, Vogel H, Filipek S, Stevens RC, Palczewski K. The Molecular Mechanism of P2Y1 Receptor Activation. Angew Chem Int Ed Engl. 2016 Aug 22;55(35):10331-5. doi: 10.1002/anie.201605147. Epub 2016 Jul 27.PMID: 27460867 Sui X, Zhang J, Golczak M, Palczewski K, Kiser PD. Key Residues for Catalytic Function and Metal Coordination in a Carotenoid Cleavage Dioxygenase. J Biol Chem. 2016 Sep 9;291(37):19401-12. doi: 10.1074/jbc.M116.744912. Epub 2016 Jul 24.PMID: 27453555 Alexander NS, Palczewska G, Stremplewski P, Wojtkowski M, Kern TS, Palczewski K. Image registration and averaging of low laser power two-photon fluorescence images of mouse retina. Biomed Opt Express. 2016 Jun 20;7(7):2671-91. doi: 10.1364/BOE.7.002671. eCollection 2016 Jul 1.PMID: 27446697 Yuan S, Peng Q, Palczewski K, Vogel H, Filipek S. Mechanistic Studies on the Stereoselectivity of the Serotonin 5-HT1A Receptor. Angew Chem Int Ed Engl. 2016 Jul 18;55(30):8661-5. doi: 10.1002/anie.201603766. Epub 2016 May 31.PMID: 27244650 Sears AE, Palczewski K. Lecithin:Retinol Acyltransferase: A Key Enzyme Involved in the Retinoid (visual) Cycle. Biochemistry. 2016 Jun 7;55(22):3082-91. doi: 10.1021/acs.biochem.6b00319. Epub 2016 May 23.PMID: 27183166 Review. Comitato A, Di Salvo MT, Turchiano G, Montanari M, Sakami S, Palczewski K, Marigo V. Dominant and recessive mutations in rhodopsin activate different cell death pathways. Hum Mol Genet. 2016 Jul 1;25(13):2801-2812. doi: 10.1093/hmg/ddw137. Epub 2016 May 5.PMID: 27149983 Free article. Palczewski K. Rural Practices: Founded in Family and Community. Mich Med. 2016 Mar-Apr;115(2):18-23.PMID: 27149754 No abstract available. Han X, Tang J, Wang J, Ren F, Zheng J, Gragg M, Kiser P, Park PS, Palczewski K, Yao X, Zhang Y. Conformational Change of Human Checkpoint Kinase 1 (Chk1) Induced by DNA Damage. J Biol Chem. 2016 Jun 17;291(25):12951-9. doi: 10.1074/jbc.M115.713248. Epub 2016 Apr 18.PMID: 27129240 Alagramam KN, Gopal SR, Geng R, Chen DH, Nemet I, Lee R, Tian G, Miyagi M, Malagu KF, Lock CJ, Esmieu WR, Owens AP, Lindsay NA, Ouwehand K, Albertus F, Fischer DF, Bürli RW, MacLeod AM, Harte WE, Palczewski K, Imanishi Y. A small molecule mitigates hearing loss in a mouse model of Usher syndrome III. Nat Chem Biol. 2016 Jun;12(6):444-51. doi: 10.1038/nchembio.2069. Epub 2016 Apr 25.PMID: 27110679 Sharma R, Schwarz C, Williams DR, Palczewska G, Palczewski K, Hunter JJ. In Vivo Two-Photon Fluorescence Kinetics of Primate Rods and Cones. Invest Ophthalmol Vis Sci. 2016 Feb;57(2):647-57. doi: 10.1167/iovs.15-17946.PMID: 26903225 Sharma R, Williams DR, Palczewska G, Palczewski K, Hunter JJ. Two-Photon Autofluorescence Imaging Reveals Cellular Structures Throughout the Retina of the Living Primate Eye. Invest Ophthalmol Vis Sci. 2016 Feb;57(2):632-46. doi: 10.1167/iovs.15-17961.PMID: 26903224 Hofmann L, Gulati S, Sears A, Stewart PL, Palczewski K. An effective thiol-reactive probe for differential scanning fluorimetry with a standard real-time polymerase chain reaction device. Anal Biochem. 2016 Apr 15;499:63-65. doi: 10.1016/j.ab.2016.01.016. Epub 2016 Feb 4.PMID: 26851339 Babino D, Golczak M, Kiser PD, Wyss A, Palczewski K, von Lintig J. The Biochemical Basis of Vitamin A3 Production in Arthropod Vision. ACS Chem Biol. 2016 Apr 15;11(4):1049-57. doi: 10.1021/acschembio.5b00967. Epub 2016 Feb 2.PMID: 26811964 Sui X, Golczak M, Zhang J, Kleinberg KA, von Lintig J, Palczewski K, Kiser PD. Utilization of Dioxygen by Carotenoid Cleavage Oxygenases. J Biol Chem. 2015 Dec 18;290(51):30212-23. doi: 10.1074/jbc.M115.696799. Epub 2015 Oct 23.PMID: 26499794 Perusek L, Sahu B, Parmar T, Maeno H, Arai E, Le YZ, Subauste CS, Chen Y, Palczewski K, Maeda A. Di-retinoid-pyridinium-ethanolamine (A2E) Accumulation and the Maintenance of the Visual Cycle Are Independent of Atg7-mediated Autophagy in the Retinal Pigmented Epithelium. J Biol Chem. 2015 Nov 27;290(48):29035-44. doi: 10.1074/jbc.M115.682310. Epub 2015 Oct 14.PMID: 26468292 Stremplewski P, Komar K, Palczewski K, Wojtkowski M, Palczewska G. Periscope for noninvasive two-photon imaging of murine retina in vivo. Biomed Opt Express. 2015 Aug 13;6(9):3352-61. doi: 10.1364/BOE.6.003352. eCollection 2015 Sep 1.PMID: 26417507 Sundermeier TR, Palczewski K. The impact of microRNA gene regulation on the survival and function of mature cell types in the eye. FASEB J. 2016 Jan;30(1):23-33. doi: 10.1096/fj.15-279745. Epub 2015 Sep 23.PMID: 26399786 Review. Sahu B, Sun W, Perusek L, Parmar V, Le YZ, Griswold MD, Palczewski K, Maeda A. Conditional Ablation of Retinol Dehydrogenase 10 in the Retinal Pigmented Epithelium Causes Delayed Dark Adaption in Mice. J Biol Chem. 2015 Nov 6;290(45):27239-27247. doi: 10.1074/jbc.M115.682096. Epub 2015 Sep 21.PMID: 26391396 Kolesnikov AV, Maeda A, Tang PH, Imanishi Y, Palczewski K, Kefalov VJ. Retinol dehydrogenase 8 and ATP-binding cassette transporter 4 modulate dark adaptation of M-cones in mammalian retina. J Physiol. 2015 Nov 15;593(22):4923-41. doi: 10.1113/JP271285. Epub 2015 Oct 18.PMID: 26350353 Jastrzebska B, Chen Y, Orban T, Jin H, Hofmann L, Palczewski K. Disruption of Rhodopsin Dimerization with Synthetic Peptides Targeting an Interaction Interface. J Biol Chem. 2015 Oct 16;290(42):25728-44. doi: 10.1074/jbc.M115.662684. Epub 2015 Sep 1.PMID: 26330551 Alexander NS, Palczewska G, Palczewski K. Semi-automated discrimination of retinal pigmented epithelial cells in two-photon fluorescence images of mouse retinas. Biomed Opt Express. 2015 Jul 23;6(8):3032-52. doi: 10.1364/BOE.6.003032. eCollection 2015 Aug 1.PMID: 26309765 Sun D, Maeno H, Gujrati M, Schur R, Maeda A, Maeda T, Palczewski K, Lu ZR. Self-Assembly of a Multifunctional Lipid With Core-Shell Dendrimer DNA Nanoparticles Enhanced Efficient Gene Delivery at Low Charge Ratios into RPE Cells. 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From atomic structures to neuronal functions of g protein-coupled receptors. Annu Rev Neurosci. 2013 Jul 8;36:139-64. doi: 10.1146/annurev-neuro-062012-170313. Epub 2013 May 15.PMID: 23682660 Review. Palczewski K, Kiser PD. Biochemistry. As good as chocolate. Science. 2013 May 3;340(6132):562-3. doi: 10.1126/science.1238521.PMID: 23641106 No abstract available. Kohno H, Chen Y, Kevany BM, Pearlman E, Miyagi M, Maeda T, Palczewski K, Maeda A. Photoreceptor proteins initiate microglial activation via Toll-like receptor 4 in retinal degeneration mediated by all-trans-retinal. J Biol Chem. 2013 May 24;288(21):15326-41. doi: 10.1074/jbc.M112.448712. Epub 2013 Apr 9.PMID: 23572532 Mustafi D, Kevany BM, Bai X, Maeda T, Sears JE, Khalil AM, Palczewski K. Evolutionarily conserved long intergenic non-coding RNAs in the eye. Hum Mol Genet. 2013 Aug 1;22(15):2992-3002. doi: 10.1093/hmg/ddt156. Epub 2013 Apr 4.PMID: 23562822 Tsybovsky Y, Orban T, Molday RS, Taylor D, Palczewski K. Molecular organization and ATP-induced conformational changes of ABCA4, the photoreceptor-specific ABC transporter. Structure. 2013 May 7;21(5):854-60. doi: 10.1016/j.str.2013.03.001. Epub 2013 Apr 4.PMID: 23562398 Tian M, Zallocchi M, Wang W, Chen CK, Palczewski K, Delimont D, Cosgrove D, Peng YW. Light-induced translocation of RGS9-1 and Gβ5L in mouse rod photoreceptors. PLoS One. 2013;8(3):e58832. doi: 10.1371/journal.pone.0058832. Epub 2013 Mar 28.PMID: 23555598 Jastrzebska B, Ringler P, Palczewski K, Engel A. The rhodopsin-transducin complex houses two distinct rhodopsin molecules. J Struct Biol. 2013 May;182(2):164-72. doi: 10.1016/j.jsb.2013.02.014. Epub 2013 Feb 28.PMID: 23458690 Yan J, Kaur S, DeLucia M, Hao C, Mehrens J, Wang C, Golczak M, Palczewski K, Gronenborn AM, Ahn J, Skowronski J. Tetramerization of SAMHD1 is required for biological activity and inhibition of HIV infection. J Biol Chem. 2013 Apr 12;288(15):10406-17. doi: 10.1074/jbc.M112.443796. 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Inflammatory priming predisposes mice to age-related retinal degeneration. J Clin Invest. 2012 Aug;122(8):2989-3001. doi: 10.1172/JCI64427. Epub 2012 Jul 17.PMID: 22797304 Hachiya A, Marchand B, Kirby KA, Michailidis E, Tu X, Palczewski K, Ong YT, Li Z, Griffin DT, Schuckmann MM, Tanuma J, Oka S, Singh K, Kodama EN, Sarafianos SG. HIV-1 reverse transcriptase (RT) polymorphism 172K suppresses the effect of clinically relevant drug resistance mutations to both nucleoside and non-nucleoside RT inhibitors. J Biol Chem. 2012 Aug 24;287(35):29988-99. doi: 10.1074/jbc.M112.351551. Epub 2012 Jul 2.PMID: 22761416 Amengual J, Golczak M, Palczewski K, von Lintig J.Lecithin:retinol acyltransferase is critical for cellular uptake of vitamin A from serum retinol-binding protein. J Biol Chem. 2012 Jul 13;287(29):24216-27. doi: 10.1074/jbc.M112.353979. Epub 2012 May 27.PMID: 22637576 Golczak M, Kiser PD, Sears AE, Lodowski DT, Blaner WS, Palczewski K. 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Detergents stabilize the conformation of phosphodiesterase 6. Biochemistry. 2011 Nov 8;50(44):9520-31. doi: 10.1021/bi2014695. Epub 2011 Oct 14.PMID: 21978030 Salon JA, Lodowski DT, Palczewski K. The significance of G protein-coupled receptor crystallography for drug discovery. Pharmacol Rev. 2011 Dec;63(4):901-37. doi: 10.1124/pr.110.003350.PMID: 21969326 Review. Jastrzebska B, Ringler P, Lodowski DT, Moiseenkova-Bell V, Golczak M, Müller SA, Palczewski K, Engel A.Rhodopsin-transducin heteropentamer: three-dimensional structure and biochemical characterization. J Struct Biol. 2011 Dec;176(3):387-94. doi: 10.1016/j.jsb.2011.08.016. Epub 2011 Sep 6.PMID: 21925606 Maeda T, Perusek L, Amengual J, Babino D, Palczewski K, von Lintig J. Dietary 9-cis-β,β-carotene fails to rescue vision in mouse models of leber congenital amaurosis. Mol Pharmacol. 2011 Nov;80(5):943-52. doi: 10.1124/mol.111.074732. Epub 2011 Aug 23.PMID: 21862692 Zhu Q, Sun W, Okano K, Chen Y, Zhang N, Maeda T, Palczewski K. Sponge transgenic mouse model reveals important roles for the microRNA-183 (miR-183)/96/182 cluster in postmitotic photoreceptors of the retina. J Biol Chem. 2011 Sep 9;286(36):31749-60. doi: 10.1074/jbc.M111.259028. Epub 2011 Jul 15.PMID: 21768104 Tsybovsky Y, Wang B, Quazi F, Molday RS, Palczewski K. Posttranslational modifications of the photoreceptor-specific ABC transporter ABCA4. Biochemistry. 2011 Aug 16;50(32):6855-66. doi: 10.1021/bi200774w. Epub 2011 Jul 8.PMID: 21721517 Mustafi D, Kevany BM, Genoud C, Okano K, Cideciyan AV, Sumaroka A, Roman AJ, Jacobson SG, Engel A, Adams MD, Palczewski K. Defective photoreceptor phagocytosis in a mouse model of enhanced S-cone syndrome causes progressive retinal degeneration. FASEB J. 2011 Sep;25(9):3157-76. doi: 10.1096/fj.11-186767. Epub 2011 Jun 9.PMID: 21659555 Peshenko IV, Olshevskaya EV, Savchenko AB, Karan S, Palczewski K, Baehr W, Dizhoor AM. Enzymatic properties and regulation of the native isozymes of retinal membrane guanylyl cyclase (RetGC) from mouse photoreceptors. Biochemistry. 2011 Jun 28;50(25):5590-600. doi: 10.1021/bi200491b. Epub 2011 Jun 6.PMID: 21598940 Jastrzebska B, Palczewski K, Golczak M. Role of bulk water in hydrolysis of the rhodopsin chromophore. J Biol Chem. 2011 May 27;286(21):18930-7. doi: 10.1074/jbc.M111.234583. Epub 2011 Apr 1.PMID: 21460218 Orban T, Palczewska G, Palczewski K. Retinyl ester storage particles (retinosomes) from the retinal pigmented epithelium resemble lipid droplets in other tissues. J Biol Chem. 2011 May 13;286(19):17248-58. doi: 10.1074/jbc.M110.195198. Epub 2011 Mar 25.PMID: 21454509 Bereta G, Palczewski K. Heterogeneous N-terminal acylation of retinal proteins results from the retina's unusual lipid metabolism. Biochemistry. 2011 May 10;50(18):3764-76. doi: 10.1021/bi200245t. Epub 2011 Apr 11.PMID: 21449552 Kiser PD, Golczak M, Maeda A, Palczewski K. Key enzymes of the retinoid (visual) cycle in vertebrate retina. Biochim Biophys Acta. 2012 Jan;1821(1):137-51. doi: 10.1016/j.bbalip.2011.03.005. Epub 2011 Apr 5.PMID: 21447403 Review. Mustafi D, Avishai A, Avishai N, Engel A, Heuer A, Palczewski K. Serial sectioning for examination of photoreceptor cell architecture by focused ion beam technology. J Neurosci Methods. 2011 May 15;198(1):70-6. doi: 10.1016/j.jneumeth.2011.03.013. Epub 2011 Mar 23.PMID: 21439323 Jastrzebska B, Debinski A, Filipek S, Palczewski K.Role of membrane integrity on G protein-coupled receptors: Rhodopsin stability and function. Prog Lipid Res. 2011 Jul;50(3):267-77. doi: 10.1016/j.plipres.2011.03.002. Epub 2011 Mar 22.PMID: 21435354 Review. Shiose S, Chen Y, Okano K, Roy S, Kohno H, Tang J, Pearlman E, Maeda T, Palczewski K, Maeda A. Toll-like receptor 3 is required for development of retinopathy caused by impaired all-trans-retinal clearance in mice. 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Probing mechanisms of photoreceptor degeneration in a new mouse model of the common form of autosomal dominant retinitis pigmentosa due to P23H opsin mutations. J Biol Chem. 2011 Mar 25;286(12):10551-67. doi: 10.1074/jbc.M110.209759. Epub 2011 Jan 11.PMID: 21224384 Mast N, Annalora AJ, Lodowski DT, Palczewski K, Stout CD, Pikuleva IA. J Structural basis for three-step sequential catalysis by the cholesterol side chain cleavage enzyme CYP11A1. Biol Chem. 2011 Feb 18;286(7):5607-13. doi: 10.1074/jbc.M110.188433. Epub 2010 Dec 15.PMID: 21159775 Amengual J, Lobo GP, Golczak M, Li HN, Klimova T, Hoppel CL, Wyss A, Palczewski K, von Lintig J. A mitochondrial enzyme degrades carotenoids and protects against oxidative stress. FASEB J. 2011 Mar;25(3):948-59. doi: 10.1096/fj.10-173906. Epub 2010 Nov 24.PMID: 21106934 Palczewska G, Maeda T, Imanishi Y, Sun W, Chen Y, Williams DR, Piston DW, Maeda A, Palczewski K. Noninvasive multiphoton fluorescence microscopy resolves retinol and retinal condensation products in mouse eyes. Nat Med. 2010 Dec;16(12):1444-9. doi: 10.1038/nm.2260. Epub 2010 Nov 14.PMID: 21076393 Palczewski K. Blind dogs that can see: pharmacological treatment of Leber congenital amaurosis caused by a defective visual cycle. Arch Ophthalmol. 2010 Nov;128(11):1483-5. doi: 10.1001/archophthalmol.2010.245.PMID: 21060052 No abstract available. Lodowski DT, Palczewski K, Miyagi M. Conformational changes in the g protein-coupled receptor rhodopsin revealed by histidine hydrogen-deuterium exchange. Biochemistry. 2010 Nov 9;49(44):9425-7. doi: 10.1021/bi101502v. Epub 2010 Oct 15.PMID: 20939497 Li H, Palczewski K, Baehr W, Clagett-Dame M. Vitamin A deficiency results in meiotic failure and accumulation of undifferentiated spermatogonia in prepubertal mouse testis. Biol Reprod. 2011 Feb;84(2):336-41. doi: 10.1095/biolreprod.110.086157. Epub 2010 Sep 29.PMID: 20881313 Huang J, Xu Z, Wang D, Ogata CM, Palczewski K, Lee X, Young NM. Characterization of the secondary binding sites of Maclura pomifera agglutinin by glycan array and crystallographic analyses. Glycobiology. 2010 Dec;20(12):1643-53. doi: 10.1093/glycob/cwq118. Epub 2010 Sep 8.PMID: 20826825 Tsybovsky Y, Molday RS, Palczewski K. The ATP-binding cassette transporter ABCA4: structural and functional properties and role in retinal disease. Adv Exp Med Biol. 2010;703:105-25. doi: 10.1007/978-1-4419-5635-4_8.PMID: 20711710 Review. Golczak M, Palczewski K. An acyl-covalent enzyme intermediate of lecithin:retinol acyltransferase. J Biol Chem. 2010 Sep 17;285(38):29217-22. doi: 10.1074/jbc.M110.152314. Epub 2010 Jul 12.PMID: 20628054 Pulagam LP, Palczewski K. Electrostatic compensation restores trafficking of the autosomal recessive retinitis pigmentosa E150K opsin mutant to the plasma membrane. J Biol Chem. 2010 Sep 17;285(38):29446-56. doi: 10.1074/jbc.M110.151407. Epub 2010 Jul 13.PMID: 20628051 Goc A, Chami M, Lodowski DT, Bosshart P, Moiseenkova-Bell V, Baehr W, Engel A, Palczewski K. Structural characterization of the rod cGMP phosphodiesterase 6. J Mol Biol. 2010 Aug 20;401(3):363-73. doi: 10.1016/j.jmb.2010.06.044. Epub 2010 Jul 1.PMID: 20600113 Lobo GP, Amengual J, Li HN, Golczak M, Bonet ML, Palczewski K, von Lintig J. Beta,beta-carotene decreases peroxisome proliferator receptor gamma activity and reduces lipid storage capacity of adipocytes in a beta,beta-carotene oxygenase 1-dependent manner. J Biol Chem. 2010 Sep 3;285(36):27891-9. doi: 10.1074/jbc.M110.132571. Epub 2010 Jun 23.PMID: 20573961 Imanishi Y, Palczewski K. Visualization of retinoid storage and trafficking by two-photon microscopy. Methods Mol Biol. 2010;652:247-61. doi: 10.1007/978-1-60327-325-1_14.PMID: 20552433 Golczak M, Bereta G, Maeda A, Palczewski K. Molecular biology and analytical chemistry methods used to probe the retinoid cycle. Methods Mol Biol. 2010;652:229-45. doi: 10.1007/978-1-60327-325-1_13.PMID: 20552432 Palczewski K. Oligomeric forms of G protein-coupled receptors (GPCRs). Trends Biochem Sci. 2010 Nov;35(11):595-600. doi: 10.1016/j.tibs.2010.05.002. Epub 2010 Jun 9.PMID: 20538466 Khelashvili G, Dorff K, Shan J, Camacho-Artacho M, Skrabanek L, Vroling B, Bouvier M, Devi LA, George SR, Javitch JA, Lohse MJ, Milligan G, Neubig RR, Palczewski K, Parmentier M, Pin JP, Vriend G, Campagne F, Filizola M. GPCR-OKB: the G Protein Coupled Receptor Oligomer Knowledge Base. Bioinformatics. 2010 Jul 15;26(14):1804-5. doi: 10.1093/bioinformatics/btq264. Epub 2010 May 25.PMID: 20501551 Palczewski K. Retinoids for treatment of retinal diseases. Trends Pharmacol Sci. 2010 Jun;31(6):284-95. doi: 10.1016/j.tips.2010.03.001.PMID: 20435355 Review. Jastrzebska B, Tsybovsky Y, Palczewski K. Complexes between photoactivated rhodopsin and transducin: progress and questions. Biochem J. 2010 Apr 28;428(1):1-10. doi: 10.1042/BJ20100270.PMID: 20423327 Review. Maeda A, Okano K, Park PS, Lem J, Crouch RK, Maeda T, Palczewski K. Palmitoylation stabilizes unliganded rod opsin. Proc Natl Acad Sci U S A. 2010 May 4;107(18):8428-33. doi: 10.1073/pnas.1000640107. Epub 2010 Apr 19.PMID: 20404157 Kiser PD, Palczewski K. Membrane-binding and enzymatic properties of RPE65. Prog Retin Eye Res. 2010 Sep;29(5):428-42. doi: 10.1016/j.preteyeres.2010.03.002. Epub 2010 Mar 19.PMID: 20304090 Review. von Lintig J, Kiser PD, Golczak M, Palczewski K. The biochemical and structural basis for trans-to-cis isomerization of retinoids in the chemistry of vision. Trends Biochem Sci. 2010 Jul;35(7):400-10. doi: 10.1016/j.tibs.2010.01.005. Epub 2010 Feb 24.PMID: 20188572 Review. Cao P, Yuan Y, Pehek EA, Moise AR, Huang Y, Palczewski K, Feng Z. Alpha-synuclein disrupted dopamine homeostasis leads to dopaminergic neuron degeneration in Caenorhabditis elegans. PLoS One. 2010 Feb 19;5(2):e9312. doi: 10.1371/journal.pone.0009312.PMID: 20174477 Orban T, Bereta G, Miyagi M, Wang B, Chance MR, Sousa MC, Palczewski K. Conformational changes in guanylate cyclase-activating protein 1 induced by Ca2+ and N-terminal fatty acid acylation. Structure. 2010 Jan 13;18(1):116-26. doi: 10.1016/j.str.2009.11.008.PMID: 20152158 Kevany BM, Palczewski K. Phagocytosis of retinal rod and cone photoreceptors. Physiology (Bethesda). 2010 Feb;25(1):8-15. doi: 10.1152/physiol.00038.2009.PMID: 20134024 Review. Golczak M, Kiser PD, Lodowski DT, Maeda A, Palczewski K. Importance of membrane structural integrity for RPE65 retinoid isomerization activity. J Biol Chem. 2010 Mar 26;285(13):9667-9682. doi: 10.1074/jbc.M109.063941. Epub 2010 Jan 25.PMID: 20100834 Lobo GP, Hessel S, Eichinger A, Noy N, Moise AR, Wyss A, Palczewski K, von Lintig J. ISX is a retinoic acid-sensitive gatekeeper that controls intestinal beta,beta-carotene absorption and vitamin A production. FASEB J. 2010 Jun;24(6):1656-66. doi: 10.1096/fj.09-150995. Epub 2010 Jan 8.PMID: 20061533 Orban T, Gupta S, Palczewski K, Chance MR. Visualizing water molecules in transmembrane proteins using radiolytic labeling methods. Biochemistry. 2010 Feb 9;49(5):827-34. doi: 10.1021/bi901889t.PMID: 20047303 Review. O'Byrne SM, Kako Y, Deckelbaum RJ, Hansen IH, Palczewski K, Goldberg IJ, Blaner WS. Multiple pathways ensure retinoid delivery to milk: studies in genetically modified mice. Am J Physiol Endocrinol Metab. 2010 Apr;298(4):E862-70. doi: 10.1152/ajpendo.00491.2009. Epub 2009 Dec 29.PMID: 20040693 Moise AR, Lobo GP, Erokwu B, Wilson DL, Peck D, Alvarez S, Domínguez M, Alvarez R, Flask CA, de Lera AR, von Lintig J, Palczewski K. Increased adiposity in the retinol saturase-knockout mouse. FASEB J. 2010 Apr;24(4):1261-70. doi: 10.1096/fj.09-147207. 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Hum Mol Genet. 2009 Aug 1;18(15):2748-60. doi: 10.1093/hmg/ddp210. Epub 2009 May 3.PMID: 19414487 Jastrzebska B, Goc A, Golczak M, Palczewski K. Phospholipids are needed for the proper formation, stability, and function of the photoactivated rhodopsin-transducin complex. Biochemistry. 2009 Jun 16;48(23):5159-70. doi: 10.1021/bi900284x.PMID: 19413332 Maeda T, Maeda A, Casadesus G, Palczewski K, Margaron P. Evaluation of 9-cis-retinyl acetate therapy in Rpe65-/- mice. Invest Ophthalmol Vis Sci. 2009 Sep;50(9):4368-78. doi: 10.1167/iovs.09-3700. Epub 2009 Apr 30.PMID: 19407008 Park PS, Sapra KT, Jastrzebska B, Maeda T, Maeda A, Pulawski W, Kono M, Lem J, Crouch RK, Filipek S, Müller DJ, Palczewski K. Modulation of molecular interactions and function by rhodopsin palmitylation. Biochemistry. 2009 May 26;48(20):4294-304. doi: 10.1021/bi900417b.PMID: 19348429 Lodowski DT, Palczewski K. Chemokine receptors and other G protein-coupled receptors. Curr Opin HIV AIDS. 2009 Mar;4(2):88-95. doi: 10.1097/COH.0b013e3283223d8d.PMID: 19339946 Review. Maeda T, Cideciyan AV, Maeda A, Golczak M, Aleman TS, Jacobson SG, Palczewski K. Loss of cone photoreceptors caused by chromophore depletion is partially prevented by the artificial chromophore pro-drug, 9-cis-retinyl acetate. Hum Mol Genet. 2009 Jun 15;18(12):2277-87. doi: 10.1093/hmg/ddp163. Epub 2009 Apr 1.PMID: 19339306 Maeda A, Maeda T, Golczak M, Chou S, Desai A, Hoppel CL, Matsuyama S, Palczewski K. Involvement of all-trans-retinal in acute light-induced retinopathy of mice. J Biol Chem. 2009 May 29;284(22):15173-83. doi: 10.1074/jbc.M900322200. Epub 2009 Mar 20.PMID: 19304658 Lodowski DT, Angel TE, Palczewski K. Comparative analysis of GPCR crystal structures. Photochem Photobiol. 2009 Mar-Apr;85(2):425-30. doi: 10.1111/j.1751-1097.2008.00516.x. Epub 2009 Jan 19.PMID: 19192200 Review. Baehr W, Palczewski K. Focus on molecules: guanylate cyclase-activating proteins (GCAPs). Exp Eye Res. 2009 Jun 15;89(1):2-3. doi: 10.1016/j.exer.2008.12.016. Epub 2009 Jan 8.PMID: 19162008 No abstract available. Cideciyan AV, Swider M, Aleman TS, Tsybovsky Y, Schwartz SB, Windsor EA, Roman AJ, Sumaroka A, Steinberg JD, Jacobson SG, Stone EM, Palczewski K. ABCA4 disease progression and a proposed strategy for gene therapy. Hum Mol Genet. 2009 Mar 1;18(5):931-41. doi: 10.1093/hmg/ddn421. Epub 2008 Dec 12.PMID: 19074458 Salom D, Wu N, Sun W, Dong Z, Palczewski K, Jordan S, Salon JA. Heterologous expression and purification of the serotonin type 4 receptor from transgenic mouse retina. Biochemistry. 2008 Dec 16;47(50):13296-307. doi: 10.1021/bi8018527.PMID: 19053287 Li C, Chan J, Haeseleer F, Mikoshiba K, Palczewski K, Ikura M, Ames JB. Structural insights into Ca2+-dependent regulation of inositol 1,4,5-trisphosphate receptors by CaBP1. J Biol Chem. 2009 Jan 23;284(4):2472-81. doi: 10.1074/jbc.M806513200. Epub 2008 Nov 13.PMID: 19008222 Goc A, Angel TE, Jastrzebska B, Wang B, Wintrode PL, Palczewski K. Different properties of the native and reconstituted heterotrimeric G protein transducin. Biochemistry. 2008 Nov 25;47(47):12409-19. doi: 10.1021/bi8015444.PMID: 18975915 Mustafi D, Palczewski K. Topology of class A G protein-coupled receptors: insights gained from crystal structures of rhodopsins, adrenergic and adenosine receptors.Mol Pharmacol. 2009 Jan;75(1):1-12. doi: 10.1124/mol.108.051938. Epub 2008 Oct 22.PMID: 18945819 Review. Jastrzebska B, Golczak M, Fotiadis D, Engel A, Palczewski K. Isolation and functional characterization of a stable complex between photoactivated rhodopsin and the G protein, transducin. FASEB J. 2009 Feb;23(2):371-81. doi: 10.1096/fj.07-114835. Epub 2008 Sep 30.PMID: 18827025 Bereta G, Kiser PD, Golczak M, Sun W, Heon E, Saperstein DA, Palczewski K. Impact of retinal disease-associated RPE65 mutations on retinoid isomerization. Biochemistry. 2008 Sep 16;47(37):9856-65. doi: 10.1021/bi800905v. Epub 2008 Aug 23.PMID: 18722466 Maeda T, Maeda A, Leahy P, Saperstein DA, Palczewski K. Effects of long-term administration of 9-cis-retinyl acetate on visual function in mice. Invest Ophthalmol Vis Sci. 2009 Jan;50(1):322-33. doi: 10.1167/iovs.08-2301. Epub 2008 Aug 15.PMID: 18708622 Jiang L, Wheaton D, Bereta G, Zhang K, Palczewski K, Birch DG, Baehr W. A novel GCAP1(N104K) mutation in EF-hand 3 (EF3) linked to autosomal dominant cone dystrophy. Vision Res. 2008 Oct;48(23-24):2425-32. doi: 10.1016/j.visres.2008.07.016. Epub 2008 Sep 16.PMID: 18706439 Maeda A, Maeda T, Golczak M, Palczewski K. Retinopathy in mice induced by disrupted all-trans-retinal clearance. J Biol Chem. 2008 Sep 26;283(39):26684-93. doi: 10.1074/jbc.M804505200. Epub 2008 Jul 25.PMID: 18658157 Imanishi Y, Sun W, Maeda T, Maeda A, Palczewski K. Retinyl ester homeostasis in the adipose differentiation-related protein-deficient retina. J Biol Chem. 2008 Sep 5;283(36):25091-102. doi: 10.1074/jbc.M802981200. Epub 2008 Jul 7.PMID: 18606814 Zhang H, Fan J, Li S, Karan S, Rohrer B, Palczewski K, Frederick JM, Crouch RK, Baehr W. Trafficking of membrane-associated proteins to cone photoreceptor outer segments requires the chromophore 11-cis-retinal. J Neurosci. 2008 Apr 9;28(15):4008-14. doi: 10.1523/JNEUROSCI.0317-08.2008.PMID: 18400900 Wongsiriroj N, Piantedosi R, Palczewski K, Goldberg IJ, Johnston TP, Li E, Blaner WS. The molecular basis of retinoid absorption: a genetic dissection. J Biol Chem. 2008 May 16;283(20):13510-9. doi: 10.1074/jbc.M800777200. Epub 2008 Mar 17.PMID: 18348983 Stephen R, Filipek S, Palczewski K, Sousa MC. Ca2+ -dependent regulation of phototransduction. Photochem Photobiol. 2008 Jul-Aug;84(4):903-10. doi: 10.1111/j.1751-1097.2008.00323.x. Epub 2008 Mar 12.PMID: 18346093 Review. Singh P, Wang B, Maeda T, Palczewski K, Tesmer JJ. 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Langmuir. 2008 Feb 19;24(4):1330-7. doi: 10.1021/la702299z.PMID: 18266338 Golczak M, Maeda A, Bereta G, Maeda T, Kiser PD, Hunzelmann S, von Lintig J, Blaner WS, Palczewski K. Metabolic basis of visual cycle inhibition by retinoid and nonretinoid compounds in the vertebrate retina. J Biol Chem. 2008 Apr 11;283(15):9543-54. doi: 10.1074/jbc.M708982200. Epub 2008 Jan 14.PMID: 18195010 Baehr W, Palczewski K. Guanylate cyclase-activating proteins and retina disease. Subcell Biochem. 2007;45:71-91. doi: 10.1007/978-1-4020-6191-2_4.PMID: 18193635 Review. Moise AR, Domínguez M, Alvarez S, Alvarez R, Schupp M, Cristancho AG, Kiser PD, de Lera AR, Lazar MA, Palczewski K. Stereospecificity of retinol saturase: absolute configuration, synthesis, and biological evaluation of dihydroretinoids. J Am Chem Soc. 2008 Jan 30;130(4):1154-5. doi: 10.1021/ja710487q. Epub 2008 Jan 8.PMID: 18179220 No abstract available. Kim YK, Wassef L, Hamberger L, Piantedosi R, Palczewski K, Blaner WS, Quadro L. Retinyl ester formation by lecithin: retinol acyltransferase is a key regulator of retinoid homeostasis in mouse embryogenesis. J Biol Chem. 2008 Feb 29;283(9):5611-21. doi: 10.1074/jbc.M708885200. Epub 2007 Dec 19.PMID: 18093970 Maeda A, Maeda T, Sun W, Zhang H, Baehr W, Palczewski K. Redundant and unique roles of retinol dehydrogenases in the mouse retina. Proc Natl Acad Sci U S A. 2007 Dec 4;104(49):19565-70. doi: 10.1073/pnas.0707477104. Epub 2007 Nov 28.PMID: 18048336 Whorton MR, Jastrzebska B, Park PS, Fotiadis D, Engel A, Palczewski K, Sunahara RK. Efficient coupling of transducin to monomeric rhodopsin in a phospholipid bilayer. J Biol Chem. 2008 Feb 15;283(7):4387-94. doi: 10.1074/jbc.M703346200. Epub 2007 Nov 22.PMID: 18033822 Stephen R, Bereta G, Golczak M, Palczewski K, Sousa MC. Stabilizing function for myristoyl group revealed by the crystal structure of a neuronal calcium sensor, guanylate cyclase-activating protein 1. Structure. 2007 Nov;15(11):1392-402. doi: 10.1016/j.str.2007.09.013.PMID: 17997965 Schonthaler HB, Lampert JM, Isken A, Rinner O, Mader A, Gesemann M, Oberhauser V, Golczak M, Biehlmaier O, Palczewski K, Neuhauss SC, von Lintig J. Evidence for RPE65-independent vision in the cone-dominated zebrafish retina. Eur J Neurosci. 2007 Oct;26(7):1940-9. doi: 10.1111/j.1460-9568.2007.05801.x. Epub 2007 Sep 14.PMID: 17868371 Jacobson SG, Aleman TS, Cideciyan AV, Heon E, Golczak M, Beltran WA, Sumaroka A, Schwartz SB, Roman AJ, Windsor EA, Wilson JM, Aguirre GD, Stone EM, Palczewski K.Human cone photoreceptor dependence on RPE65 isomerase. Proc Natl Acad Sci U S A. 2007 Sep 18;104(38):15123-8. doi: 10.1073/pnas.0706367104. Epub 2007 Sep 11.PMID: 17848510 Park PS, Lodowski DT, Palczewski K. Activation of G protein-coupled receptors: beyond two-state models and tertiary conformational changes. Annu Rev Pharmacol Toxicol. 2008;48:107-41. doi: 10.1146/annurev.pharmtox.48.113006.094630.PMID: 17848137 Review. Lodowski DT, Salom D, Le Trong I, Teller DC, Ballesteros JA, Palczewski K, Stenkamp RE. Reprint of "Crystal packing analysis of Rhodopsin crystals" [J. Struct. Biol. 158 (2007) 455-462]. J Struct Biol. 2007 Aug;159(2):253-60. doi: 10.1016/S1047-8477(07)00166-9.PMID: 17660064 Li N, Salom D, Zhang L, Harris T, Ballesteros JA, Golczak M, Jastrzebska B, Palczewski K, Kurahara C, Juan T, Jordan S, Salon JA. Heterologous expression of the adenosine A1 receptor in transgenic mouse retina. Biochemistry. 2007 Jul 17;46(28):8350-9. doi: 10.1021/bi700154h. Epub 2007 Jun 20.PMID: 17580959 Kiser PD, Lodowski DT, Palczewski K. Purification, crystallization and structure determination of native GroEL from Escherichia coli lacking bound potassium ions. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 Jun 1;63(Pt 6):457-61. doi: 10.1107/S1744309107020295. Epub 2007 May 5.PMID: 17554162 Skrabanek L, Murcia M, Bouvier M, Devi L, George SR, Lohse MJ, Milligan G, Neubig R, Palczewski K, Parmentier M, Pin JP, Vriend G, Javitch JA, Campagne F, Filizola M. Requirements and ontology for a G protein-coupled receptor oligomerization knowledge base. BMC Bioinformatics. 2007 May 30;8:177. doi: 10.1186/1471-2105-8-177.PMID: 17537266 Nickell S, Park PS, Baumeister W, Palczewski K. J Three-dimensional architecture of murine rod outer segments determined by cryoelectron tomography. Cell Biol. 2007 Jun 4;177(5):917-25. doi: 10.1083/jcb.200612010. Epub 2007 May 29.PMID: 17535966 Sun W, Gerth C, Maeda A, Lodowski DT, Van Der Kraak L, Saperstein DA, Héon E, Palczewski K. Novel RDH12 mutations associated with Leber congenital amaurosis and cone-rod dystrophy: biochemical and clinical evaluations. Vision Res. 2007 Jul;47(15):2055-66. doi: 10.1016/j.visres.2007.04.005. Epub 2007 May 21.PMID: 17512964 Moise AR, Noy N, Palczewski K, Blaner WS. Delivery of retinoid-based therapies to target tissues. Biochemistry. 2007 Apr 17;46(15):4449-58. doi: 10.1021/bi7003069. Epub 2007 Mar 23.PMID: 17378589 Review. Lodowski DT, Salom D, Le Trong I, Teller DC, Ballesteros JA, Palczewski K, Stenkamp RE. Crystal packing analysis of Rhodopsin crystals. J Struct Biol. 2007 Jun;158(3):455-62. doi: 10.1016/j.jsb.2007.01.017. Epub 2007 Feb 9.PMID: 17374491 Pin JP, Neubig R, Bouvier M, Devi L, Filizola M, Javitch JA, Lohse MJ, Milligan G, Palczewski K, Parmentier M, Spedding M. International Union of Basic and Clinical Pharmacology. LXVII. Recommendations for the recognition and nomenclature of G protein-coupled receptor heteromultimers. Pharmacol Rev. 2007 Mar;59(1):5-13. doi: 10.1124/pr.59.1.5.PMID: 17329545 Review. Park PS, Sapra KT, Koliński M, Filipek S, Palczewski K, Muller DJ. Stabilizing effect of Zn2+ in native bovine rhodopsin. J Biol Chem. 2007 Apr 13;282(15):11377-85. doi: 10.1074/jbc.M610341200. 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J Biol Chem. 2007 Jan 19;282(3):2081-90. doi: 10.1074/jbc.M608315200. Epub 2006 Nov 19.PMID: 17114808 Free article. Isken A, Holzschuh J, Lampert JM, Fischer L, Oberhauser V, Palczewski K, von Lintig J Sequestration of retinyl esters is essential for retinoid signaling in the zebrafish embryo. J Biol Chem. 2007 Jan 12;282(2):1144-51. doi: 10.1074/jbc.M609109200. Epub 2006 Nov 10.PMID: 17098734 Free article. Palczewski K, Hofmann KP, Baehr W. Rhodopsin--advances and perspectives. Vision Res. 2006 Dec;46(27):4425-6. doi: 10.1016/j.visres.2006.10.009.PMID: 17098052 Free article. No abstract available. Salom D, Lodowski DT, Stenkamp RE, Le Trong I, Golczak M, Jastrzebska B, Harris T, Ballesteros JA, Palczewski K. Crystal structure of a photoactivated deprotonated intermediate of rhodopsin. Proc Natl Acad Sci U S A. 2006 Oct 31;103(44):16123-8. doi: 10.1073/pnas.0608022103. Epub 2006 Oct 23.PMID: 17060607 Maeda A, Maeda T, Imanishi Y, Sun W, Jastrzebska B, Hatala DA, Winkens HJ, Hofmann KP, Janssen JJ, Baehr W, Driessen CA, Palczewski K. Retinol dehydrogenase (RDH12) protects photoreceptors from light-induced degeneration in mice. J Biol Chem. 2006 Dec 8;281(49):37697-704. doi: 10.1074/jbc.M608375200. Epub 2006 Oct 10.PMID: 17032653 Maeda A, Maeda T, Palczewski K. Improvement in rod and cone function in mouse model of Fundus albipunctatus after pharmacologic treatment with 9-cis-retinal. Invest Ophthalmol Vis Sci. 2006 Oct;47(10):4540-6. doi: 10.1167/iovs.06-0215.PMID: 17003450 Travis GH, Golczak M, Moise AR, Palczewski K. Diseases caused by defects in the visual cycle: retinoids as potential therapeutic agents. Annu Rev Pharmacol Toxicol. 2007;47:469-512. doi: 10.1146/annurev.pharmtox.47.120505.105225.PMID: 16968212 Review. Modzelewska A, Filipek S, Palczewski K, Park PS. Arrestin interaction with rhodopsin: conceptual models. Cell Biochem Biophys. 2006;46(1):1-15. doi: 10.1385/CBB:46:1:1.PMID: 16943619 Domínguez M, Alvarez R, Pérez M, Palczewski K, de Lera AR. The role of the 11-cis-retinal ring methyl substituents in visual pigment formation. Chembiochem. 2006 Nov;7(11):1815-25. doi: 10.1002/cbic.200600207.PMID: 16941510 Haire SE, Pang J, Boye SL, Sokal I, Craft CM, Palczewski K, Hauswirth WW, Semple-Rowland SL. Light-driven cone arrestin translocation in cones of postnatal guanylate cyclase-1 knockout mouse retina treated with AAV-GC1. Invest Ophthalmol Vis Sci. 2006 Sep;47(9):3745-53. doi: 10.1167/iovs.06-0086.PMID: 16936082 Maeda A, Maeda T, Golczak M, Imanishi Y, Leahy P, Kubota R, Palczewski K. Effects of potent inhibitors of the retinoid cycle on visual function and photoreceptor protection from light damage in mice. Mol Pharmacol. 2006 Oct;70(4):1220-9. doi: 10.1124/mol.106.026823. Epub 2006 Jul 12.PMID: 16837623 Salom D, Le Trong I, Pohl E, Ballesteros JA, Stenkamp RE, Palczewski K, Lodowski DT. Improvements in G protein-coupled receptor purification yield light stable rhodopsin crystals. J Struct Biol. 2006 Dec;156(3):497-504. doi: 10.1016/j.jsb.2006.05.003. Epub 2006 Jun 2.PMID: 16837211 Tu DC, Owens LA, Anderson L, Golczak M, Doyle SE, McCall M, Menaker M, Palczewski K, Van Gelder RN. Inner retinal photoreception independent of the visual retinoid cycle. Proc Natl Acad Sci U S A. 2006 Jul 5;103(27):10426-10431. doi: 10.1073/pnas.0600917103. Epub 2006 Jun 20.PMID: 16788071 Palczewski K. G protein-coupled receptor rhodopsin. Annu Rev Biochem. 2006;75:743-67. doi: 10.1146/annurev.biochem.75.103004.142743.PMID: 16756510 Review. Zhu L, Imanishi Y, Filipek S, Alekseev A, Jastrzebska B, Sun W, Saperstein DA, Palczewski K. Autosomal recessive retinitis pigmentosa and E150K mutation in the opsin gene. J Biol Chem. 2006 Aug 4;281(31):22289-22298. doi: 10.1074/jbc.M602664200. Epub 2006 May 31.PMID: 16737970 Williams ML, Coleman JE, Haire SE, Aleman TS, Cideciyan AV, Sokal I, Palczewski K, Jacobson SG, Semple-Rowland SL. Lentiviral expression of retinal guanylate cyclase-1 (RetGC1) restores vision in an avian model of childhood blindness. PLoS Med. 2006 Jun;3(6):e201. doi: 10.1371/journal.pmed.0030201. Epub 2006 May 23.PMID: 16700630 Stephen R, Palczewski K, Sousa MC. The crystal structure of GCAP3 suggests molecular mechanism of GCAP-linked cone dystrophies. J Mol Biol. 2006 Jun 2;359(2):266-75. doi: 10.1016/j.jmb.2006.03.042. Epub 2006 Apr 3.PMID: 16626734 Fotiadis D, Jastrzebska B, Philippsen A, Müller DJ, Palczewski K, Engel A. Structure of the rhodopsin dimer: a working model for G-protein-coupled receptors. Curr Opin Struct Biol. 2006 Apr;16(2):252-9. doi: 10.1016/j.sbi.2006.03.013. Epub 2006 Mar 29.PMID: 16567090 Review. Maeda A, Maeda T, Imanishi Y, Golczak M, Moise AR, Palczewski K. Aberrant metabolites in mouse models of congenital blinding diseases: formation and storage of retinyl esters. Biochemistry. 2006 Apr 4;45(13):4210-9. doi: 10.1021/bi052382x.PMID: 16566595 Tanuj Sapra K, Park PS, Filipek S, Engel A, Müller DJ, Palczewski K. Detecting molecular interactions that stabilize native bovine rhodopsin. J Mol Biol. 2006 Apr 21;358(1):255-69. doi: 10.1016/j.jmb.2006.02.008. Epub 2006 Feb 20.PMID: 16519899 Jastrzebska B, Fotiadis D, Jang GF, Stenkamp RE, Engel A, Palczewski K. Functional and structural characterization of rhodopsin oligomers. J Biol Chem. 2006 Apr 28;281(17):11917-22. doi: 10.1074/jbc.M600422200. Epub 2006 Feb 22.PMID: 16495215 Mansoor SE, Palczewski K, Farrens DL. Rhodopsin self-associates in asolectin liposomes. Proc Natl Acad Sci U S A. 2006 Feb 28;103(9):3060-5. doi: 10.1073/pnas.0511010103. Epub 2006 Feb 21.PMID: 16492772 Park PS, Palczewski K. Imaging G protein-coupled receptor islands. Nat Chem Biol. 2005 Sep;1(4):184-5. doi: 10.1038/nchembio0905-184.PMID: 16408027 No abstract available. Zhang L, Salom D, He J, Okun A, Ballesteros J, Palczewski K, Li N. Expression of functional G protein-coupled receptors in photoreceptors of transgenic Xenopus laevis. Biochemistry. 2005 Nov 8;44(44):14509-18. doi: 10.1021/bi051386z.PMID: 16262251 Batten ML, Imanishi Y, Tu DC, Doan T, Zhu L, Pang J, Glushakova L, Moise AR, Baehr W, Van Gelder RN, Hauswirth WW, Rieke F, Palczewski K. Pharmacological and rAAV gene therapy rescue of visual functions in a blind mouse model of Leber congenital amaurosis. PLoS Med. 2005 Nov;2(11):e333. doi: 10.1371/journal.pmed.0020333. Epub 2005 Nov 1.PMID: 16250670 Maeda T, Lem J, Palczewski K, Haeseleer F. A critical role of CaBP4 in the cone synapse. 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Diversity of guanylate cyclase-activating proteins (GCAPs) in teleost fish: characterization of three novel GCAPs (GCAP4, GCAP5, GCAP7) from zebrafish (Danio rerio) and prediction of eight GCAPs (GCAP1-8) in pufferfish (Fugu rubripes). J Mol Evol. 2004 Aug;59(2):204-217. doi: 10.1007/s00239-004-2614-y.PMID: 15486694 Tu DC, Batten ML, Palczewski K, Van Gelder RN. Nonvisual photoreception in the chick iris. Science. 2004 Oct 1;306(5693):129-31. doi: 10.1126/science.1101484.PMID: 15459395 Zhu L, Jang GF, Jastrzebska B, Filipek S, Pearce-Kelling SE, Aguirre GD, Stenkamp RE, Acland GM, Palczewski K. A naturally occurring mutation of the opsin gene (T4R) in dogs affects glycosylation and stability of the G protein-coupled receptor. J Biol Chem. 2004 Dec 17;279(51):53828-39. doi: 10.1074/jbc.M408472200. Epub 2004 Sep 30.PMID: 15459196 Haeseleer F, Imanishi Y, Maeda T, Possin DE, Maeda A, Lee A, Rieke F, Palczewski K. Essential role of Ca2+-binding protein 4, a Cav1.4 channel regulator, in photoreceptor synaptic function. Nat Neurosci. 2004 Oct;7(10):1079-87. doi: 10.1038/nn1320. Epub 2004 Sep 26.PMID: 15452577 Subramanian L, Crabb JW, Cox J, Durussel I, Walker TM, van Ginkel PR, Bhattacharya S, Dellaria JM, Palczewski K, Polans AS. Ca2+ binding to EF hands 1 and 3 is essential for the interaction of apoptosis-linked gene-2 with Alix/AIP1 in ocular melanoma. Biochemistry. 2004 Sep 7;43(35):11175-86. doi: 10.1021/bi048848d.PMID: 15366927 Moise AR, Kuksa V, Imanishi Y, Palczewski K. Identification of all-trans-retinol:all-trans-13,14-dihydroretinol saturase. J Biol Chem. 2004 Nov 26;279(48):50230-42. doi: 10.1074/jbc.M409130200. Epub 2004 Sep 9.PMID: 15358783 Liang Y, Fotiadis D, Maeda T, Maeda A, Modzelewska A, Filipek S, Saperstein DA, Engel A, Palczewski K. Rhodopsin signaling and organization in heterozygote rhodopsin knockout mice. J Biol Chem. 2004 Nov 12;279(46):48189-96. doi: 10.1074/jbc.M408362200. Epub 2004 Aug 26.PMID: 15337746 Mammen A, Simpson PJ, Nighorn A, Imanishi Y, Palczewski K, Ronnett GV, Moon C. Hippocalcin in the olfactory epithelium: a mediator of second messenger signaling. Biochem Biophys Res Commun. 2004 Oct 1;322(4):1131-9. doi: 10.1016/j.bbrc.2004.07.123.PMID: 15336960 Palczewski K, Sokal I, Baehr W. Guanylate cyclase-activating proteins: structure, function, and diversity. Biochem Biophys Res Commun. 2004 Oct 1;322(4):1123-30. doi: 10.1016/j.bbrc.2004.07.122.PMID: 15336959 Review. Imanishi Y, Gerke V, Palczewski K. Retinosomes: new insights into intracellular managing of hydrophobic substances in lipid bodies. J Cell Biol. 2004 Aug 16;166(4):447-53. doi: 10.1083/jcb.200405110.PMID: 15314061 Review. Filipek S, Krzysko KA, Fotiadis D, Liang Y, Saperstein DA, Engel A, Palczewski K. A concept for G protein activation by G protein-coupled receptor dimers: the transducin/rhodopsin interface. Photochem Photobiol Sci. 2004 Jun;3(6):628-38. doi: 10.1039/b315661c. Epub 2004 Feb 27.PMID: 15170495 Fotiadis D, Liang Y, Filipek S, Saperstein DA, Engel A, Palczewski K. The G protein-coupled receptor rhodopsin in the native membrane. FEBS Lett. 2004 Apr 30;564(3):281-288. doi: 10.1016/S0014-5793(04)00194-2.PMID: 15111110 Aleman TS, Jacobson SG, Chico JD, Scott ML, Cheung AY, Windsor EA, Furushima M, Redmond TM, Bennett J, Palczewski K, Cideciyan AV. Impairment of the transient pupillary light reflex in Rpe65(-/-) mice and humans with leber congenital amaurosis. Invest Ophthalmol Vis Sci. 2004 Apr;45(4):1259-71. doi: 10.1167/iovs.03-1230.PMID: 15037595 Imanishi Y, Batten ML, Piston DW, Baehr W, Palczewski K. Noninvasive two-photon imaging reveals retinyl ester storage structures in the eye. J Cell Biol. 2004 Feb 2;164(3):373-83. doi: 10.1083/jcb.200311079. Epub 2004 Jan 26.PMID: 14745001 Sokal I, Alekseev A, Palczewski K. 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J Biol Chem. 2003 Jun 13;278(24):21655-21662. doi: 10.1074/jbc.M302536200. Epub 2003 Mar 27.PMID: 12663652 Mirzadegan T, Benkö G, Filipek S, Palczewski K. Sequence analyses of G-protein-coupled receptors: similarities to rhodopsin. Biochemistry. 2003 Mar 18;42(10):2759-67. doi: 10.1021/bi027224+.PMID: 12627940 Review. Fritze O, Filipek S, Kuksa V, Palczewski K, Hofmann KP, Ernst OP. Role of the conserved NPxxY(x)5,6F motif in the rhodopsin ground state and during activation. Proc Natl Acad Sci U S A. 2003 Mar 4;100(5):2290-5. doi: 10.1073/pnas.0435715100. Epub 2003 Feb 24.PMID: 12601165 Haeseleer F, Palczewski K. Calmodulin and Ca2+-binding proteins (CaBPs): variations on a theme. Adv Exp Med Biol. 2002;514:303-17. doi: 10.1007/978-1-4615-0121-3_18.PMID: 12596929 Review. Filipek S, Teller DC, Palczewski K, Stenkamp R. The crystallographic model of rhodopsin and its use in studies of other G protein-coupled receptors. 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J Biol Chem. 2002 Nov 1;277(44):42315-42324. doi: 10.1074/jbc.M206014200. Epub 2002 Aug 9.PMID: 12176994 Yang J, McBride S, Mak DO, Vardi N, Palczewski K, Haeseleer F, Foskett JK. Identification of a family of calcium sensors as protein ligands of inositol trisphosphate receptor Ca(2+) release channels. Proc Natl Acad Sci U S A. 2002 May 28;99(11):7711-6. doi: 10.1073/pnas.102006299.PMID: 12032348 Howes KA, Pennesi ME, Sokal I, Church-Kopish J, Schmidt B, Margolis D, Frederick JM, Rieke F, Palczewski K, Wu SM, Detwiler PB, Baehr W. GCAP1 rescues rod photoreceptor response in GCAP1/GCAP2 knockout mice. EMBO J. 2002 Apr 2;21(7):1545-54. doi: 10.1093/emboj/21.7.1545.PMID: 11927539 Van Hooser JP, Liang Y, Maeda T, Kuksa V, Jang GF, He YG, Rieke F, Fong HK, Detwiler PB, Palczewski K. Recovery of visual functions in a mouse model of Leber congenital amaurosis. J Biol Chem. 2002 May 24;277(21):19173-82. doi: 10.1074/jbc.M112384200. Epub 2002 Mar 15.PMID: 11897783 Lee A, Westenbroek RE, Haeseleer F, Palczewski K, Scheuer T, Catterall WA. Differential modulation of Ca(v)2.1 channels by calmodulin and Ca2+-binding protein 1. Nat Neurosci. 2002 Mar;5(3):210-7. doi: 10.1038/nn805.PMID: 11865310 Imanishi Y, Li N, Sokal I, Sowa ME, Lichtarge O, Wensel TG, Saperstein DA, Baehr W, Palczewski K. Characterization of retinal guanylate cyclase-activating protein 3 (GCAP3) from zebrafish to man. Eur J Neurosci. 2002 Jan;15(1):63-78. doi: 10.1046/j.0953-816x.2001.01835.x.PMID: 11860507 Haeseleer F, Imanishi Y, Sokal I, Filipek S, Palczewski K. Calcium-binding proteins: intracellular sensors from the calmodulin superfamily. Biochem Biophys Res Commun. 2002 Jan 18;290(2):615-23. doi: 10.1006/bbrc.2001.6228.PMID: 11785943 Review. Palczewski K. Crystal Structure of Rhodopsin: Implication for Vision and Beyond. Mechanisms of Acti. 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Proc Natl Acad Sci U S A. 2001 Aug 14;98(17):9948-53. doi: 10.1073/pnas.171308998. Epub 2001 Aug 7.PMID: 11493703 Teller DC, Okada T, Behnke CA, Palczewski K, Stenkamp RE. Advances in determination of a high-resolution three-dimensional structure of rhodopsin, a model of G-protein-coupled receptors (GPCRs). Biochemistry. 2001 Jul 3;40(26):7761-72. doi: 10.1021/bi0155091.PMID: 11425302 Review. No abstract available. Jang GF, Van Hooser JP, Kuksa V, McBee JK, He YG, Janssen JJ, Driessen CA, Palczewski K. Characterization of a dehydrogenase activity responsible for oxidation of 11-cis-retinol in the retinal pigment epithelium of mice with a disrupted RDH5 gene. A model for the human hereditary disease fundus albipunctatus. J Biol Chem. 2001 Aug 31;276(35):32456-65. doi: 10.1074/jbc.M104949200. Epub 2001 Jun 20.PMID: 11418621 Yan W, Jang GF, Haeseleer F, Esumi N, Chang J, Kerrigan M, Campochiaro M, Campochiaro P, Palczewski K, Zack DJ. 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