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Distinguished Speaker Series | Mike (Przemyslaw) Sapieha, PhD

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Location
https://ucihealth.zoom.us/j/94483669170?pwd=WUd1clg2aUM1bnpPVHd3MlkwTUN1Zz09
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The Center for Translational Vision Research Distinguished Speaker Series, also known as "Friday Seminars" showcases innovative research across the world. The seminar series has now been expanded to include lectures by experts on topics ranging from Ophthalmology, Genetics, Biochemistry, Neurobiology, Imaging, Computational Sciences to Novel Ophthalmic Treatments.

All talks are hybrid. You can join us in person at

The Susan & Henry Samueli College of Health Sciences 

Sue Gross Auditorium.

You can also join us by zoom. Zoom link and information are on your right and in the calendar links above.

November 22, 2024 | Mike (Przemyslaw) Sapieha, PhD

Senolytics in Retinal Vascular Disease

 

Learn More About the Distinguished Speaker Series

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 Mike (Przemyslaw) Sapieha, PhD,
Mike (Przemyslaw) Sapieha, PhD,
  • Professor of Ophthalmology, Biochemistry and Molecular Medicine, University of Montreal, Canada

The current research focuses in the laboratory fall into three areas:

Neurovascular Cross-Talk in Disease. We seek to identify the mechanisms by which neuronal stress impacts the blood vessels that supply their metabolic needs. We focus on outer retinal neurons and vessels, which are directly affected in diabetes.

Neuroimmune Communication in Disease. Recently, our group has identified a neuroimmune paradigm by which stressed neurons produce non-classical chemoattractive agents that recruit subsets of mononuclear phagocytes to sites of vascular lesion. Further elucidation of these mechanisms is essential to better understanding the pathogenesis of diabetic retinopathy.

Therapeutic Modulation of ω-3-Polyunsaturated fatty acid (PUFA) metabolism for vascular diseases of the retina. Another axis of research in my lab investigates the role of ω-3 PUFAs in angiogenesis and neuronal homeostasis. We have recently described that elevated dietary intake of ω-3 PUFAs lower vitreal VEGF levels in human patients suffering from Age-related Macular Degeneration. Moreover, we identified that certain ω-3 derivatives directly block VEGF-induced pathological angiogenesis.