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Distinguished Speaker Series | Karl J. Wahlin, PhD

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Location
https://ucihealth.zoom.us/j/94483669170?pwd=WUd1clg2aUM1bnpPVHd3MlkwTUN1Zz09
Event Type

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The Center for Translational Vision Research Distinguished Speaker Series, also known as "Friday Seminars" showcases innovative research across the world. The seminar series has now been expanded to include lectures by experts on topics ranging from Ophthalmology, Genetics, Biochemistry, Neurobiology, Imaging, Computational Sciences to Novel Ophthalmic Treatments.

All talks are hybrid. You can join us in person at

The Susan & Henry Samueli College of Health Sciences 

Sue Gross Auditorium.

You can also join us by zoom. Zoom link and information are on your right and in the calendar links above.

November 1, 2024 | Karl J. Wahlin, PhD

Cell and genome engineering for exploring human retinal development and disease.

 

Learn More About the Distinguished Speaker Series

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Karl J. Wahlin, PhD,
Karl J. Wahlin, PhD,
  • Associate Professor of Ophthalmology, Director of the Richard C. Atkinson Laboratory for Regenerative Ophthalmology, The Shiley Eye Institute, University of California San Diego

Advances in stem cell culturing and differentiation across the world now make it possible to explore human retinal development in vitro. Our lab uses human pluripotent stem cells (PSCs) grown as 3D “mini-retinas” or as dissociated 2D monolayers to investigate this biology. Using gene editing techniques (e.g. CRISPR-Cas9) we are exploring the fundamental biology of the retina by engineering cells to express cell type specific fluorescent protein reporters and then studying them from the first neural retina cells to the final stages of differentiation. It is hoped that this information will lead to the potential application as a transplantable source of tissue, a model for eye development and a system to develop “disease-in-a-dish” models for retinal degenerative disease.