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The Center for Translational Vision Research Distinguished Speaker Series, also known as "Friday Seminars" showcases innovative research across the world. The seminar series has now been expanded to include lectures by experts on topics ranging from Ophthalmology, Genetics, Biochemistry, Neurobiology, Imaging, Computational Sciences to Novel Ophthalmic Treatments.
All talks are hybrid. You can join us in person at
You can also join us by zoom. Zoom link and information are on your right and in the calendar links above.
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A major effort in our lab is directed toward understanding the transcriptional regulatory networks that orchestrate the development and function of photoreceptors. We are employing a wide range of experimental and computational techniques to decipher these networks. Recently, we generated comprehensive maps of rod- and cone-specific open chromatin using ATAC-seq and have leveraged these maps to elucidate the differences in cis-regulatory grammar between these two cell types. We are now using a massively parallel reporter assay called CRE-seq to further interrogate the architecture of photoreceptor cis-regulatory elements. Our ultimate goal is to create a complete, quantitative model of photoreceptor transcriptional regulation including a detailed cis-regulatory grammar. This model will serve as a template for translating between both coding and non-coding variants and the complex cellular phenotypes of photoreceptors that result in blindness.