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Distinguished Speaker Series | Rafal Holubowicz, PhD

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Location
https://ucihealth.zoom.us/j/94483669170?pwd=WUd1clg2aUM1bnpPVHd3MlkwTUN1Zz09
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The Center for Translational Vision Research Distinguished Speaker Series, also known as "Friday Seminars" showcases innovative research across the world. The seminar series has now been expanded to include lectures by experts on topics ranging from Ophthalmology, Genetics, Biochemistry, Neurobiology, Imaging, Computational Sciences to Novel Ophthalmic Treatments.

All talks are hybrid. You can join us in person at

The Gavin Herbert Eye Institute Building,

3rd Floor Cavanaugh Conference Room

You can also join us by zoom. Zoom link and information are on your right and in the calendar links above.

May 30, 2025 | Rafal Holubowicz, PhD

Precision genome editing in the eye using protein lipid nanoparticles

 

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Rafal Holubowicz, PhD
Rafal Holubowicz, PhD
  • Postdoctoral Fellow, Center for Translational Vision Research, Department of Ophthalmology, University of California, Irvine, CA

Dr. Holubowicz is interested in genome augmentation using derivatives of CRISPR-Cas9, namely base editors (CBE, ABE) and prime editors (PE), in the context of retinal diseases. Currently, delivery of base and prime editors relies on viral vectors, which may cause prolonged expression of these enzymes and toxic accumulation of the off-target genome editing products. Ribonucleoprotein particles (RNPs) are an alternative, which due to their shorter lifetime in the cell can repair disease-causing mutations without modifying other sites in the DNA. By inventing a way to deliver active and specific RNPs to retinal tissues, Dr. Holubowicz wants to make a foundation for novel treatments with lifelong therapeutic effects. Dr. Holubowicz is currently a member of the Krzysztof Palczewski Lab at the Center for Translational Vision Research at UCI.