Distinguished Speaker Series | Jason Meyer, PhD

Fri, Oct 7 2022, 5:30 - 6:30am

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The Center for Translational Vision Research Distinguished Speaker Series, also known as "Friday Seminars" showcases innovative research across the world. The seminar series has now been expanded to include lectures by experts on topics ranging from Ophthalmology, Genetics, Biochemistry, Neurobiology, Imaging, Computational Sciences to Novel Ophthalmic Treatments.

October 7, 2022 | Jason S. Meyer, PhD

Building a better in vitro disease model for glaucoma-associated neurodegeneration

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Jason S. Meyer, PhD

Associate Professor of Medical & Molecular Genetics, Indiana University School of Medicine

The Meyer Lab, led by Jason Meyer, PhD, focuses on mechanisms of neural development and neurodegeneration using human pluripotent stem cell-derived neurons. Fundamentally, the research emphasizes the in vitro three dimensional organization and differentiation of these stem cells into organoids which serve as a model of the temporal and spatial organization of neural tissue. From these organoids, different individual cell

Genetic determinants of neurodegenerative diseases are created through either the derivation of stem cells directly from patient samples, or through the introduction of the mutation with gene editing approaches. Once harboring these mutations and differentiated into the affected cell types, these cells serve as a powerful in vitro model of neurodegenerative mechanisms in a human cell model.

Currently, major emphases in the lab focus upon both the intrinsic mechanisms of disease leading to the loss of neurons, as well as those extrinsic mechanisms resulting from adversely affected interactions between neurons and glia.