Cores for Vision Research Administration Bioinformatics Core Ocular Microanatomy Core (OM Core) Visual Function and Non-invasive Ocular Imaging Core (VFNOI Core) Ocular Mass Spectrometry, Lipidomics, and Proteomics Core (OMSLP Core) Ophthalmic Testing Core (OTC) Bioinformatics Core Home Research Cores For Vision Research Bioinformatics Core Bioinformatics Core The Bioinformatics Core at the University of California, Irvine (UCI) supports and enhances vision research by providing advanced computational analysis and high-performance computing resources. The Core enables investigators to manage, analyze, and interpret large-scale datasets, strengthening ongoing projects and facilitating new data-driven studies. By expanding computational capabilities, it contributes to increased research productivity and innovation in vision science at UCI. INITIAL SERVICE REQUEST FORM Rui Chen, PhD Professor, Department of Ophthalmology and Visual Sciences Jin Li, PhD Manager, Bioinformatics Core Reservation sign-up link for Equipment use Most resources used by the Bioinformatics Core are accessed through high-performance computing systems rather than physical instrumentation. The Core is located on the 6th floor of the Falling Leaves Foundation Research Building, where the manager, Dr. Jin Li, maintains a workspace in close proximity to vision researchers in the School of Medicine. These computational resources are provided through the HPC3 cluster managed by the Research Cyberinfrastructure Center (RCIC) at UC Irvine and can be accessed remotely, allowing investigators to perform data analysis directly from their own laboratories in an efficient and flexible manner. In addition to shared computing resources, the Core maintains dedicated storage and server infrastructure to support data storage and development of vision-specific databases. Access to the Bioinformatics Core is provided through a centralized reservation and request system, allowing investigators to request computational support, data analysis services, and storage resources. Reservation sign-up link for equipment use Major Equipment Bioinformatics core The bioinformatics core performs computing primarily on the high-performance computing resources HPC3 cluster managed by the Research Cyberinfrastructure Center (RCIC) at UC Irvine, which consists of 237 nodes and a total of 10,576 cores. In addition, the cluster has 14 GPU nodes with Nvidia V100 GPUs, 18 GPU nodes with Nvidia A30 GPUs, and 4 GPU nodes with Nvidia A100 GPUs, totaling 136 GPUs. The cluster is connected to more than 8PB of storage where the bioinformatic core has 100Tb allocated disc space that can be further expanded as needed. The HPC3 cluster is managed by a highly skilled team 24/7 who offer extensive support for both hardware and software needs. This resource is shared across UCI and can be accessed by all research labs, allowing for seamless data and code sharing. In addition to the shared computing resources, the Bioinformatic core maintains a dedicated standalone storage server with 132 Tb of RAID5 protected disc space for long term data storage, providing sufficient capacity to support proposed activities. Finally, the Bioinformatics core maintains a dedicated standalone Linux web server for the development of vision specific database as proposed. The server has a 36-core CPU, 256 GB of RAM, a 7 TB hard drive, providing sufficient computational capacity to support database development and deployment.